Ultrasound-accelerated Thrombolysis for the Treatment of Deep Vein Thrombosis: Initial Clinical Experience

2008 ◽  
Vol 19 (4) ◽  
pp. 521-528 ◽  
Author(s):  
Sanjiv Parikh ◽  
Amir Motarjeme ◽  
Thomas McNamara ◽  
Rodney Raabe ◽  
Klaus Hagspiel ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Experience ◽  
Vein Thrombosis ◽  
Deep Vein ◽  
Initial Clinical Experience

scholarly journals Clinical Experience of Direct Oral Anticoagulant in Patients with Deep Vein Thrombosis

2018 ◽  
Vol 29 (1) ◽  
pp. 13-19
Author(s):  
Kiyoaki Niimi ◽  
Akio Koyama ◽  
Yohei Kawai ◽  
Naohiro Akita ◽  
Takayuki Fujii ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Experience ◽  
Oral Anticoagulant ◽  
Direct Oral Anticoagulant ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Diagnosis of deep vein thrombosis using 3D black-blood thrombus imaging (BTI): preliminary clinical experience

2016 ◽  
Vol 18 (Suppl 1) ◽  
pp. Q58 ◽  
Author(s):  
Hanwei Chen ◽  
Guoxi Xie ◽  
Jianke Liang ◽  
Wei Deng ◽  
Zhuonan He ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Clinical Experience ◽  
Black Blood ◽  
Vein Thrombosis ◽  
Thrombus Imaging ◽  
Deep Vein

scholarly journals Diagnosis and Treatment of Deep Vein Thrombosis in the Emergency Department: Results of an Italian Nominal Group Technique Study

2020 ◽  
Vol 26 ◽  
pp. 107602962095972
Author(s):  
Aldo Salvi ◽  
Cinzia Nitti ◽  
Andrea Fabbri ◽  
Paolo Groff ◽  
Enrico Giuseppe Ruggiero ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Early Diagnosis ◽  
Clinical Experience ◽  
Nominal Group Technique ◽  
Diagnosis And Treatment ◽  
Nominal Group ◽  
Vein Thrombosis ◽  
Consensus Statements ◽  
Deep Vein ◽  
Group Technique

Early diagnosis and treatment of deep vein thrombosis (DVT) is a main issue in the Emergency setting. With the aim of assisting clinicians in the diagnosis and the subsequent management of DVT in the Emergency Departments, a Nominal Group Technique (NGT) study was conducted. A panel of 5 Italian experts developed 21 consensus statements based on available evidence and their clinical experience. The agreed consensus statements may assist clinicians in applying the results of clinical studies and clinical experience to routine care settings, providing guidance on all aspects of the risk assessment, prophylaxis, early diagnosis and appropriate treatment of DVT in the EDs.

Feasibility Study of Catheter-directed Thrombolysis with Recombinant Staphylokinase in Deep Venous Thrombosis

1998 ◽  
Vol 79 (03) ◽  
pp. 517-519 ◽  
Author(s):  
Stephane Heymans ◽  
Raymond Verhaeghe ◽  
Luc Stockx ◽  
Désiré Collen
Keyword(s):  
Deep Vein Thrombosis ◽  
Continuous Infusion ◽  
High Speed ◽  
Minor Bleeding ◽  
Vein Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Long Term Follow Up ◽  
Valve Function ◽  
Rotating Impeller ◽  
Deep Vein

SummaryThe feasibility of catheter-directed thrombolysis with recombinant staphylokinase was evaluated in six selected patients with deep vein thrombosis. The patients underwent intrathrombus infusion of recombinant staphylokinase (2 mg bolus followed by a continuous infusion of 1 mg/h). Heparin was given via the catheter as a bolus (5000 U) and as a continuous infusion (1000 U/h). Complete lyis was obtained in five patients and partial lysis in one patient. Complications consisted of minor bleeding in four subjects. Symptomatic reocclusion occurred in one. Debulking of the thrombus mass by a high speed rotating impeller (n = 1) and stenting (n = 3) were used as additional interventions. An underlying anatomical abnormality was present in two patients. Long term follow up revealed normal patency in all patients and normal valve function in four patients. Symptomatic venous insufficiency with valve dysfunction was present in the two with a second thrombotic episode.Thus catheter-directed infusion of recombinant staphylokinase in patients with deep vein thrombosis appears feasible and may be associated with a high frequency of thrombolysis. Larger studies to define the clinical benefit of this treatment appear to be warranted.

Deep Vein Thrombosis and Fibrinolysis

1991 ◽  
Vol 66 (04) ◽  
pp. 426-429 ◽  
Author(s):  
Marcel Levi ◽  
Anthonie W A Lensing ◽  
Harry R Büller ◽  
Paolo Prandoni ◽  
Gerard Dooijewaard ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Tissue Type ◽  
Controlled Study ◽  
First Episode ◽  
Control Group ◽  
Vein Thrombosis ◽  
Type Plasminogen Activator ◽  
Deep Vein

SummaryIn the present study 57 consecutive patients with a first episode of venographically proven deep vein thrombosis were investigated to evaluate the release of tissue-type plasminogen activator (t-PA) and of urokinase-type plasminogen activator (u-PA) in response to DDAVP stimulation as well as the resting plasminogen activator inhibitor (PAI) concentration, comparing this to the results obtained in 66 similar patients with a clinical suspicion of thrombosis but with a normal venogram. All assays were performed without knowledge of the patient's status.Four patients in the deep vein thrombosis-group (7%) had an absent u-PA antigen response upon DDAVP infusion, while a normal response was observed in all control subjects. Patients and controls showed similar increases in t-PA antigen level upon DDAVP. High resting PAI antigen levels were encountered in 5 patients in the deep vein thrombosis-group (9%) and in 6 subjects in the control group (9%).The results from this controlled study indicate that a defective release of u-PA may occur in patients with deep vein thrombosis and may have pathogenetic significance. Furthermore it is concluded that elevation of PAI levels cannot be considered as a specific risk factor for venous thrombosis.

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