The use of Bayesian methods for evaluating the performance of a virus-like particles-based ELISA for serology of hepatitis E virus infection in swine

2010 ◽  
Vol 163 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Nicolas Rose ◽  
Annie Boutrouille ◽  
Christelle Fablet ◽  
François Madec ◽  
Marc Eloit ◽  
...  
Keyword(s):  
Virus Infection ◽  
Bayesian Methods ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Like Particles

Severe course of Hepatitis E Virus infection in a patient with pre-existing autoimmune liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
S Schlosser ◽  
J Pflaum ◽  
K Weigand ◽  
JJ Wenzel ◽  
W Jilg ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Autoimmune Liver Disease

Serological and molecular studies on subclinical hepatitis E virus infection using periodic serum samples obtained from healthy individuals

2005 ◽  
Vol 76 (4) ◽  
pp. 526-533 ◽  
Author(s):  
Takehiro Mitsui ◽  
Yukie Tsukamoto ◽  
Shigeru Suzuki ◽  
Chikao Yamazaki ◽  
Kazuo Masuko ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Healthy Individuals ◽  
Serum Samples ◽  
Molecular Studies

scholarly journals Efficient Production of Chimeric Hepatitis B Virus-Like Particles Bearing an Epitope of Hepatitis E Virus Capsid by Transient Expression in Nicotiana benthamiana

Life ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 64
Author(s):  
Gergana Zahmanova ◽  
Milena Mazalovska ◽  
Katerina Takova ◽  
Valentina Toneva ◽  
Ivan Minkov ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nicotiana Benthamiana ◽  
Hepatitis E Virus ◽  
Chimeric Protein ◽  
Hepatitis E ◽  
Core Antigen ◽  
Efficient Production ◽  
Virus Like Particles ◽  
B Virus

The core antigen of hepatitis B virus (HBcAg) is capable of self-assembly into virus-like particles (VLPs) when expressed in a number of heterologous systems. Such VLPs are potential carriers of foreign antigenic sequences for vaccine design. In this study, we evaluated the production of chimeric HBcAg VLPs presenting a foreign epitope on their surface, the 551–607 amino acids (aa) immunological epitope of the ORF2 capsid protein of hepatitis E virus. A chimeric construct was made by the insertion of 56 aa into the immunodominant loop of the HBcAg. The sequences encoding the chimera were inserted into the pEAQ-HT vector and infiltrated into Nicotiana benthamiana leaves. The plant-expressed chimeric HBcHEV ORF2 551–607 protein was recognized by an anti-HBcAg mAb and anti-HEV IgG positive swine serum. Electron microscopy showed that plant-produced chimeric protein spontaneously assembled into “knobbly” ~34 nm diameter VLPs. This study shows that HBcAg is a promising carrier platform for the neutralizing epitopes of hepatitis E virus (HEV) and the chimeric HBcAg/HEV VLPs could be a candidate for a bivalent vaccine.

Clinical and virologic features of hepatitis E virus infection at a university hospital in Japan between 2000 and 2019

2020 ◽  
Vol 92 (12) ◽  
pp. 3572-3583
Author(s):  
Naoto Sato ◽  
Shunji Watanabe ◽  
Kouichi Miura ◽  
Naoki Morimoto ◽  
Yoshinari Takaoka ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
University Hospital

scholarly journals Burden of hepatitis E virus infection in pregnancy and maternofoetal outcomes: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jean Joel Bigna ◽  
Abdou Fatawou Modiyinji ◽  
Jobert Richie Nansseu ◽  
Marie A. Amougou ◽  
Moise Nola ◽  
...  
Keyword(s):  
Systematic Review ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Meta Analysis ◽  
Hepatitis E ◽  
In Pregnancy

First Serological Study of Hepatitis E Virus Infection in Backyard Pigs from Serbia

2010 ◽  
Vol 2 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Diana Lupulovic ◽  
Sava Lazic ◽  
Jasna Prodanov-Radulovic ◽  
Nereida Jiménez de Oya ◽  
Estela Escribano-Romero ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Serological Study ◽  
Backyard Pigs

O105 MICE WITH HUMAN LIVERS AS A NEW MODEL OF HEPATITIS E VIRUS INFECTION AND PRECLINICAL DRUG EVALUATION

2014 ◽  
Vol 60 (1) ◽  
pp. S42-S43 ◽  
Author(s):  
M. Lutgehetmann ◽  
K. Giersch ◽  
L. Allweiss ◽  
A.W. Lohse ◽  
S. Polywka ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Drug Evaluation ◽  
Hepatitis E ◽  
New Model ◽  
Human Livers

scholarly journals Acute hepatitis E virus infection in human immunodeficiency virus-positive men and women in Nepal: Not quite a rare entity

Hepatology ◽  
2016 ◽  
Vol 64 (3) ◽  
pp. 1006-1007 ◽  
Author(s):  
Birendra Prasad Gupta ◽  
Ananta Shrestha ◽  
Anurag Adhikari ◽  
Thupten Kelsang Lama ◽  
Binaya Sapkota
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Rare Entity ◽  
Men And Women ◽  
Immunodeficiency Virus ◽  
Acute Hepatitis E
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