scholarly journals Antithrombotic Therapy and Endovascular Stents Are Effective Treatment for Blunt Carotid Injuries: Results From Long-Term Follow-up

2007 ◽  
Vol 46 (4) ◽  
pp. 823
Author(s):  
N.M. Edwards ◽  
T.C. Fabian ◽  
J.A. Claridge
Keyword(s):  
Effective Treatment ◽  
Antithrombotic Therapy ◽  
Endovascular Stents ◽  
Long Term Follow Up

Abstract 3164: Combined Antithrombotic Therapy in Atrial Fibrillation. Role of different Antiplatelet Strategies

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Francisco Pérez-Gómez ◽  
Ramón Bover ◽  
Antonio Salvador ◽  
María Paz Maluenda ◽  
Susana Asenjo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Antithrombotic Therapy ◽  
Primary Outcome ◽  
Combined Therapy ◽  
Severe Bleeding ◽  
Vascular Events ◽  
Long Term Follow Up ◽  
Ischemic Events

The NASPEAF trial showed that combined anticoagulant plus antiplatelet therapy was more effective than anticoagulant alone at reducing vascular events in atrial fibrillation (AF) patients. We planned both to validate this benefit during a longer follow-up of patients included in that trial and to assess the hypothesis that combination of anticoagulation plus different antiplatelets could be differently effective and/or safe in patients from that trial and new ones followed-up for at least one year. Methods: Five hundred and seventy-four AF patients were included. Anticoagulation alone therapy (INR 2.0 –3.0) was used as control group (g) 1 to compare with anticoagulation (1.9 –2.5) plus either trifusal 600 mg/d (g2), trifusal 300 mg/d (g3) or aspirin 100 mg/d (g4). Median follow-up was 50, 32, 50 and 37 months respectively. The primary outcome was a composite of ischemic/haemorrhagic stroke, systemic/coronary ischemic events and cardiovascular death. The incidence of severe bleeding was also collected. Anticoagulation was regularly controlled in dedicated units. Results: Long-term follow-up showed benefit of combined anticoagulant plus trifusal 600 mg/d vs anticoagulant alone (primary outcome 2.86% pt/years in g1 vs 1.36% in g2, P=0.014). Combined therapy using other antiplatelet strategies was less effective or safe due to higher incidence of ischemic events when using trifusal 300 mg/d (2.44% pt/years in g3 vs 0.61% in g2, P=0.031) as well as more severe bleeding events with aspirin 100 mg/d (6.60% pt/years in g4 vs 1.51% in g2, P=0.008). Groups g1, g3 and g4 had similar primary outcome (2.86% pt/years, 2.67% and 2.83% respectively). Mean INR and other anticoagulation parameters were similar in the three combined therapy groups. Non-gastric severe bleeding incidence during combined therapy with trifusal 600 mg/d (0.3% pt/years) was lower than that observed in either anticoagulant alone therapy (2.1%, P=0.012) or combined with aspirin (6.60%, P=0.008). In conclusion, long-term follow-up of the NASPEAF trial confirmed the benefit of combined antithrombotic therapy over anticoagulant alone therapy. Combined therapy with aspirin 100 mg/d instead of trifusal 600 mg/d caused higher incidence of severe bleeding.

Children’s Enuresis: Some Background Information and a Suggested Treatment for Use by Teachers, Therapists and Parents

1983 ◽  
Vol 7 (2) ◽  
pp. 33-36
Author(s):  
Christopher F. Sharpley ◽  
S. E. Everingham
Keyword(s):  
Effective Treatment ◽  
Comparative Effectiveness ◽  
Treatment Retention ◽  
Background Information ◽  
Review Of The Literature ◽  
Analytic Review ◽  
Long Term Follow Up

AbstractThe treatment of children’s enuresis has witnessed a number of theoretical and practical variations. While the incidence of enuresis is substantial, there is little agreement in the wider literature regarding the most effective treatment. The present paper reports on a detailed meta-analytic review of the literature, drawing some limited conclusions as to the comparative effectiveness of five categories of treatment, with particular reference to long term follow-up data. While the use of pad and bell is shown as equally effective as retention training at the end of the treatment, retention training emerges as superior over 6 to 12 months of follow-up. Basic instructions are given for the use of this method.

Infected vertebroplasty requiring 360° spinal reconstruction: long-term follow-up review

2006 ◽  
Vol 5 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Praveen V. Mummaneni ◽  
David H. Walker ◽  
Junichi Mizuno ◽  
Gerald E. Rodts
Keyword(s):  
Effective Treatment ◽  
Surgical Management ◽  
Systemic Infection ◽  
Infectious Complications ◽  
Compression Fractures ◽  
Spinal Reconstruction ◽  
Long Term Follow Up

✓ Transpedicular vertebroplasty has been established as a safe and effective treatment of thoracic and lumbar compression fractures. Complications are rare, and infectious complications requiring surgical management have only been reported once in the literature. The authors present two cases of infectious complications requiring surgical management. They emphasize that systemic infection is a contraindication to the performance of vertebroplasty. The serious nature of these infections, their surgical management, and strategies for avoiding them are discussed.

Catheter fixation and ligation: a simple technique for ventriculostomy management following endovascular stenting

2013 ◽  
Vol 118 (5) ◽  
pp. 1009-1013 ◽  
Author(s):  
Justin M. Sweeney ◽  
Rohit Vasan ◽  
Harry R. van Loveren ◽  
A. Samy Youssef ◽  
Siviero Agazzi
Keyword(s):  
Antithrombotic Therapy ◽  
External Ventricular Drainage ◽  
Ventricular Drainage ◽  
Management Options ◽  
Shunt System ◽  
Long Term Follow Up ◽  
Unique Method ◽  
Risk Of Hemorrhage

The object of this study was to describe a unique method of managing ventriculostomy catheters in patients on antithrombotic therapy following endovascular treatment of ruptured intracranial aneurysms. The authors retrospectively reviewed 3 cases in which a unique method of ventriculostomy management was used to successfully avoid catheter-related hemorrhage while the patient was on dual antiplatelet therapy. In this setting, ventriculostomy catheters are left in place and fixed to the calvarium with titanium straps effectively ligating them. The catheter is divided and the distal end is removed. The proximal end can be directly connected to a distal shunt system during this stage or at a later date if necessary. The method described in this report provided a variety of management options for patients requiring external ventricular drainage for subarachnoid hemorrhage. No patient suffered catheter-related hemorrhage. This preliminary report demonstrates a safe and effective method for discontinuing external ventricular drainage and/or placing a ventriculoperitoneal shunt in the setting of active coagulopathy or antithrombotic therapy. The technique avoids both the risk of hemorrhage related to catheter removal and reinsertion and the thromboembolic risks associated with the reversal of antithrombotic therapy. Some aneurysm centers have avoided the use of stent-assisted coiling in cases of ruptured aneurysms to circumvent ventriculostomy-related complications; however, the method described herein should allow continued use of this important treatment option in ruptured aneurysm cases. Further investigation in a larger cohort with long-term follow-up is necessary to define the associated risks of infection using this method.

Long-Term Follow-Up of Liver Transplantation for Budd-Chiari Syndrome With Antithrombotic Therapy Based on the Etiology

2011 ◽  
Vol 92 (3) ◽  
pp. 341-345 ◽  
Author(s):  
Srinath Chinnakotla ◽  
Goran B. Klintmalm ◽  
Peter Kim ◽  
Koji Tomiyama ◽  
Erik Klintmalm ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antithrombotic Therapy ◽  
Budd Chiari Syndrome ◽  
Long Term Follow Up ◽  
Chiari Syndrome

Encopresis - an Overview

1985 ◽  
Vol 9 (4) ◽  
pp. 11-14
Author(s):  
Joy Rainey
Keyword(s):  
Effective Treatment ◽  
Social Worker ◽  
Family Life ◽  
Treatment Regime ◽  
Clinical Psychologist ◽  
Long Term Follow Up

Joy Rainey is a Social Worker and Clinical Psychologist. Until recently, she was Senior Social Worker at Southern Family Life.The aim of this paper is to provide an overview of treatment for encopresis, within a behaviourist framework. Whilst behaviourists’ methods demonstrate merit, many studies omit long term follow-up, and there is a tendency to view the child in isolation from his family. Behaviourist programs can be enhanced by viewing the child in the context of his family which the author sees as crucial when planning an appropriate and effective treatment regime.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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