Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women

Life Sciences ◽  
2005 ◽  
Vol 76 (18) ◽  
pp. 2137-2145 ◽  
Author(s):  
Wayne Huey-Herng Sheu ◽  
Huei-Min Linda Chin ◽  
Wen-Jane Lee ◽  
Chu-Jen Wan ◽  
Hsiu-Yueh Su ◽  
...  
Keyword(s):  
Folic Acid ◽  
Weight Reduction ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Controlled Study ◽  
Obese Women ◽  
Prospective Evaluation ◽  
Acid Supplementation ◽  
Double Blinded

Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats

2017 ◽  
Vol 42 (10) ◽  
pp. 1015-1022 ◽  
Author(s):  
Shanshan Cui ◽  
Wen Li ◽  
Xin Lv ◽  
Pengyan Wang ◽  
Guowei Huang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Antioxidant Capacity ◽  
Wistar Rats ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Serum Folate ◽  
Antioxidative Capacity ◽  
High Fat ◽  
Acid Supplementation ◽  
Atherosclerotic Lesions

Atherosclerosis is a chronic disease that can seriously endanger human life. Folic acid supplementation modulates several disorders, including atherosclerosis, via its antiapoptotic and antioxidative properties. This study investigated whether folic acid alleviates atherogenesis by restoring homocysteine levels and antioxidative capacity in atherosclerosis Wistar rats. To this end, 28 Wistar rats were randomly divided into 4 groups (7 rats/group) as follows: (i) wild-type group, fed only the AIN-93 semi-purified rodent diet (folic acid: 2.1 mg/kg); (ii) high-fat + folic acid-deficient group (HF+DEF) (folic acid: 0.2 mg/kg); (iii) high-fat + normal folic acid group (folic acid: 2.1 mg/kg); and (iv) high-fat + folic acid-supplemented group (folic acid: 4.2 mg/kg). After 12 weeks, histopathological changes in the atherosclerotic lesions of the aortic arch were determined. In addition, serum folate levels, plasma homocysteine levels, plasma S-adenosyl-homocysteine levels, antioxidant status, oxidant status, and lipid profiles were evaluated. The results show aggravated atherosclerotic lesions in the HF+DEF group. Folic acid supplementation increased concentrations of serum folate. Further, folic acid supplementation increased high-density lipoprotein-cholesterol, decreased plasma homocysteine levels, and improved antioxidant capacity in atherogenic rats. These findings are consistent with the hypothesis that folic acid alleviates atherogenesis by reducing plasma homocysteine levels and improving antioxidant capacity in rats fed a high-fat diet.

Folic acid supplementation reduces plasma homocysteine in postmenopausal women

2016 ◽  
Vol 36 (4) ◽  
pp. 492-495 ◽  
Author(s):  
Fariba Almassinokiani ◽  
Maryam Kashanian ◽  
Peyman Akbari ◽  
Elaheh Mossayebi ◽  
Elena Sadeghian
Keyword(s):  
Folic Acid ◽  
Postmenopausal Women ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Acid Supplementation

The effect of folic acid supplementation on plasma homocysteine in an elderly population

QJM ◽  
2002 ◽  
Vol 95 (1) ◽  
pp. 27-35 ◽  
Author(s):  
A. Rydlewicz ◽  
J.A. Simpson ◽  
R.J. Taylor ◽  
C.M. Bond ◽  
M.H.N. Golden
Keyword(s):  
Folic Acid ◽  
Elderly Population ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Acid Supplementation
Sign in / Sign up

Export Citation Format

Share Document