Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

Rheumatoid arthritis is the most frequent chronic inflammatory rheumatism. Its management, especially in the case of early inflammatory rheumatism should be immediate, if possible, during the first six months of the evolution of the disease and should be adapted to the potential evolution of rheumatism because it is a therapeutic emergency. Management was drastically improved by a better knowledge of pathophysiology (role of anti-CCP antibodies established), a new diagnostic approach (new 2010 ACR/EULAR criteria and new international recommendations), and new prognostic and therapeutic approaches (biologics).

Download Full-text

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2020.598263 ◽

2020 ◽

Vol 8 ◽

Author(s):

Kaixuan Chen ◽

Yurui Jiao ◽

Ling Liu ◽

Mei Huang ◽

Chen He ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Stem Cells ◽

Bone Marrow ◽

Bone Resorption ◽

Bone Remodeling ◽

Bone Cells ◽

Therapeutic Approaches ◽

Tightly Coupled ◽

Mensenchymal Stem Cells

The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

Download Full-text

Role of CCL2/CCR2 axis in the immunopathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches

Life Sciences ◽

10.1016/j.lfs.2021.119034 ◽

2021 ◽

Vol 269 ◽

pp. 119034

Author(s):

Fatemeh Moadab ◽

Hossein Khorramdelazad ◽

Mitra Abbasifard

Keyword(s):

Rheumatoid Arthritis ◽

Therapeutic Approaches

Download Full-text

Predictors of functional disability in early Rheumatoid Arthritis: The role of pain-coping and social support

PsycEXTRA Dataset ◽

10.1037/e536922011-019 ◽

1998 ◽

Author(s):

A. W. M. Evers ◽

F. W. Kraaimaat ◽

R. Geenen ◽

J. W. J. Bijlsma

Keyword(s):

Rheumatoid Arthritis ◽

Social Support ◽

Early Rheumatoid Arthritis ◽

Functional Disability ◽

Pain Coping

Download Full-text

To be or not to be optimistic when one is chronically ill: The role of optimism in relation to adaptation to type 1 diabetes mellitus, rheumatoid arthritis and multiple sclerosis

PsycEXTRA Dataset ◽

10.1037/e537142011-002 ◽

2000 ◽

Author(s):

Marijda Fournier

Keyword(s):

Rheumatoid Arthritis ◽

Diabetes Mellitus ◽

Multiple Sclerosis ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Chronically Ill

Download Full-text

Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

Melatonin Research ◽

10.32794/mr11250059 ◽

2020 ◽

Vol 3 (2) ◽

pp. 216-242 ◽

Cited By ~ 1

Author(s):

Mayuri Shukla ◽

Areechun Sotthibundhu ◽

Piyarat Govitrapong

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Adult Neurogenesis ◽

Adult Brain ◽

Therapeutic Approaches ◽

Therapeutic Implications ◽

Cell Proliferation And Differentiation ◽

Proliferation And Differentiation ◽

Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.

Download Full-text