Toll-like receptor 4: An attractive therapeutic target for acute kidney injury

Life Sciences ◽  
2021 ◽  
Vol 271 ◽  
pp. 119155
Author(s):  
Ankush Kumar Jha ◽  
Shobhit Gairola ◽  
Sourav Kundu ◽  
Pakpi Doye ◽  
Abu Mohammad Syed ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Therapeutic Target ◽  
Kidney Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Attractive Therapeutic Target

scholarly journals Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury

2011 ◽  
Vol 79 (3) ◽  
pp. 288-299 ◽  
Author(s):  
Jianlin Chen ◽  
Reji John ◽  
James A. Richardson ◽  
John M. Shelton ◽  
Xin J. Zhou ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Endothelial Activation ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Ischemic Acute Kidney Injury

scholarly journals Physical Exercise Exacerbates Acute Kidney Injury Induced by LPS via Toll-Like Receptor 4

2020 ◽  
Vol 11 ◽  
Author(s):  
Talita Guerreiro Rodrigues Húngaro ◽  
Leandro Ceotto Freitas-Lima ◽  
Marcos Fernandes Gregnani ◽  
Mauro Sérgio Perilhão ◽  
Thaís Alves-Silva ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Physical Exercise ◽  
Kidney Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Loganetin protects against rhabdomyolysis‐induced acute kidney injury by modulating the toll‐like receptor 4 signalling pathway

2019 ◽  
Vol 176 (8) ◽  
pp. 1106-1121 ◽  
Author(s):  
Jie Li ◽  
Yu‐jun Tan ◽  
Ming‐zhi Wang ◽  
Ying Sun ◽  
Guang‐yan Li ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Signalling Pathway ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules

2011 ◽  
Vol 27 (10) ◽  
pp. 1847-1854 ◽  
Author(s):  
Christopher Y. Lu ◽  
Pamela D. Winterberg ◽  
Jianlin Chen ◽  
John R. Hartono
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep

2011 ◽  
Vol 114 (5) ◽  
pp. 1130-1137 ◽  
Author(s):  
Johan Fenhammar ◽  
Mats Rundgren ◽  
Jakob Forestier ◽  
Sigridur Kalman ◽  
Stefan Eriksson ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Index ◽  
Arterial Pressure ◽  
Creatinine Clearance ◽  
Blood Urea Nitrogen ◽  
Urine Output ◽  
Kidney Injury ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Arterial Lactate

Background This study was conducted to investigate the role of toll-like receptor 4 (TLR4) in mediating acute kidney injury in endotoxemic sheep using the selective TLR4 inhibitor TAK-242. Methods A randomized, controlled, experimental study was performed with 20 adult Texel crossbred sheep. Before an Escherichia coli lipopolysaccharide infusion (3 μg · kg(-1) · h(-1) for 24 h), sheep were randomized to receive a bolus dose (2 mg/kg), followed by a continuous infusion (4 mg · kg(-1) · 24 h(-1)) of either TAK-242 (n = 7) or vehicle (n = 7). A third group of lipopolysaccharide-treated sheep (n = 6) received norepinephrine, titrated to maintain baseline arterial blood pressure. Results Endotoxin infusion established a state of hyperdynamic circulation, with an increased cardiac index, hypotension, and tachycardia. Urine output and creatinine clearance decreased throughout the experiment, together with increasing plasma creatinine, blood urea nitrogen, and arterial lactate concentrations. After 24 h, TLR4 inhibition had significantly (P ≤ 0.001) attenuated the mean ± SEM decrease in arterial pressure (97 ± 3 vs. 71 ± 4 mmHg), urine output (1.16 ± 0.15 vs. 0.13 ± 0.05 ml · kg(-1) · h(-1)), and creatinine clearance (126 ± 13 vs. 20 ± 7 ml/min) compared with vehicle-treated animals. Furthermore, arterial lactate, plasma creatinine, and blood urea nitrogen concentrations were significantly lower in the TAK-242 group versus the vehicle-treated animals. Compared with TLR4 inhibition, norepinephrine caused similar effects on arterial pressure, cardiac index, and heart rate; however, it did not attenuate the decrease in urine output or creatinine clearance. Conclusions These results indicate a critical role for TLR4 in impairing renal function during ovine endotoxemia that is independent of changes in central hemodynamics.

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