High-mobility group box protein-1 induces acute pancreatitis through activation of neutrophil extracellular trap and subsequent production of IL-1β

Life Sciences ◽  
2021 ◽  
pp. 119231
Author(s):  
Xingmao Wu ◽  
Zhenyu Yang ◽  
Haiyuan Wang ◽  
Yang Zhao ◽  
Xiaopeng Gao ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group ◽  
Neutrophil Extracellular Trap ◽  
Extracellular Trap

scholarly journals High Mobility Group Box 1 Protein in Cerebral Thromboemboli

2021 ◽  
Vol 22 (20) ◽  
pp. 11276
Author(s):  
Fabian Essig ◽  
Lilith Babilon ◽  
Christoph Vollmuth ◽  
Alexander M. Kollikowski ◽  
Mirko Pham ◽  
...  
Keyword(s):  
Mechanical Thrombectomy ◽  
High Mobility ◽  
Large Vessel ◽  
High Mobility Group ◽  
Neutrophil Extracellular Trap ◽  
Spatial Proximity ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
Molecular Pattern ◽  
Hmgb1 Expression

High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. HMGB1 was detected in all thromboemboli, accounting for 1.7% (IQR 0.6–6.2%) of the total thromboemboli area and was found to be colocalized with neutrophils and NETs and in spatial proximity to platelets. Correlation analysis revealed that the detection of HMGB1 was strongly related to the number of neutrophils (r = 0.58, p = 0.0002) and platelets (r = 0.51, p = 0.001). Our results demonstrate that HMGB1 is a substantial constituent of thromboemboli causing large vessel occlusion stroke.

Increase of High-Mobility Group Box Chromosomal Protein 1 in Blood and Injured Organs in Experimental Severe Acute Pancreatitis

Pancreas ◽  
2007 ◽  
Vol 34 (4) ◽  
pp. 487-488 ◽  
Author(s):  
Takeo Yasuda ◽  
Takashi Ueda ◽  
Makoto Shinzeki ◽  
Hidehiro Sawa ◽  
Takahiro Nakajima ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein

scholarly journals Association between high mobility group box-1 protein expression and cell death in acute pancreatitis

2017 ◽  
Vol 15 (6) ◽  
pp. 4021-4026 ◽  
Author(s):  
Enjun Gao ◽  
Yanfeng Jiang ◽  
Zhituo Li ◽  
Dongbo Xue ◽  
Weihui Zhang
Keyword(s):  
Acute Pancreatitis ◽  
Cell Death ◽  
Protein Expression ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Platelet IP6K1 regulates neutrophil extracellular trap–microparticle complex formation in acute pancreatitis

JCI Insight ◽  
2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Raeh Madhi ◽  
Milladur Rahman ◽  
Dler Taha ◽  
Johan Linders ◽  
Mohammed Merza ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Complex Formation ◽  
Neutrophil Extracellular Trap ◽  
Extracellular Trap
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