Anti-arrhythmic and inotropic effects of empagliflozin following myocardial ischemia

Life Sciences ◽  
2021 ◽  
pp. 119440
Author(s):  
Mohammed Ali Azam ◽  
Praloy Chakraborty ◽  
Daoyuan Si ◽  
BeiBei Du ◽  
Stéphane Massé ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Inotropic Effects

Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms

2002 ◽  
Vol 282 (4) ◽  
pp. H1341-H1349 ◽  
Author(s):  
Gary F. Merrill
Keyword(s):  
Hydrogen Peroxide ◽  
Myocardial Ischemia ◽  
Protein Oxidation ◽  
Control Function ◽  
Ischemia Reperfusion ◽  
Low Flow ◽  
Buffer Solution ◽  
Inotropic Effects ◽  
Light Production ◽  
Antioxidant Mechanisms

In the current study, the cardioprotective efficacy of 0.35 mmol/l acetaminophen administered 10 min after the onset of a 20-min period of global, low-flow myocardial ischemia was investigated. Matched control hearts were administered an equal volume of Krebs-Henseleit physiological buffer solution (vehicle). In separate groups of hearts, the concentration-dependent, negative inotropic properties of hydrogen peroxide and the ability of acetaminophen to attenuate these actions, as well as the effects of acetaminophen on ischemia-reperfusion-mediated protein oxidation, were studied. Acetaminophen-treated hearts regained a significantly greater fraction of baseline, preischemia control function during reperfusion than vehicle-treated hearts. For example, contractility [rate of maximal developed pressure in the left ventricle (±dP/d t max)] after 10 min of reperfusion was 109 ± 24 and 42 ± 9 mmHg/s ( P < 0.05), respectively, in the two groups. The corresponding pressure-rate products were 1,840 ± 434 vs. 588 ± 169 mmHg · beats · min−1 ( P < 0.05). Acetaminophen attenuated peroxynitrite-mediated chemiluminescence in the early minutes of reperfusion (e.g., at 6 min, corresponding values for peak light production were ∼8 × 106 counts/min for vehicle vs. <4 × 106counts/min for acetaminophen, P < 0.05) and the negative inotropic effects of exogenously administered hydrogen peroxide (e.g., at 0.4 mmol/l hydrogen peroxide, pressure-rate products were ∼1.0 × 104 and 3.8 × 103 mmHg · beats · min−1in acetaminophen- and vehicle-treated hearts, respectively, P < 0.05). Ischemia-mediated protein oxidation was reduced by acetaminophen. The ability of acetaminophen to attenuate the damaging effects of peroxynitrite and hydrogen peroxide and to limit protein oxidation suggest antioxidant mechanisms are responsible for its cardioprotective properties during postischemia-reperfusion.

11 Inotropic effects of insulin in failing human myocardium

2003 ◽  
Vol 2 (1) ◽  
pp. 2
Author(s):  
D VONLEWINSKI ◽  
S BRUNS ◽  
E BISPING ◽  
B PIESKE
Keyword(s):  
Human Myocardium ◽  
Inotropic Effects

Low Bone Density Linked to Myocardial Ischemia

2007 ◽  
Vol 37 (1) ◽  
pp. 13
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Bone Density ◽  
Myocardial Ischemia ◽  
Low Bone Density

Hemodynamic and Inotropic Effects of Endothelin Antagonists

1998 ◽  
Vol 31 (2) ◽  
pp. 487A
Author(s):  
M Beyer
Keyword(s):  
Inotropic Effects ◽  
Endothelin Antagonists
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