Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: Long-term follow-up of radiological findings

Lung Cancer ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 298-301 ◽  
Author(s):  
Hiroshi Soda ◽  
Yoichi Nakamura ◽  
Katsumi Nakatomi ◽  
Nanae Tomonaga ◽  
Hiroyuki Yamaguchi ◽  
...  
2002 ◽  
Vol 73 (2) ◽  
pp. 386-392 ◽  
Author(s):  
Ken Kodama ◽  
Masahiko Higashiyama ◽  
Hideoki Yokouchi ◽  
Koji Takami ◽  
Keiko Kuriyama ◽  
...  

Medicine ◽  
2016 ◽  
Vol 95 (4) ◽  
pp. e2634 ◽  
Author(s):  
Kyung Bum Nam ◽  
Tae Jung Kim ◽  
Jeong-Soo Park ◽  
Myung Jin Chung ◽  
Kyung Won Lee

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 7548-7548
Author(s):  
Takashi Eguchi ◽  
Ryoichi Kondo ◽  
Satoshi Kawakami ◽  
Mina Matsushita ◽  
Tetsu Takeda ◽  
...  

7548 Background: Cases with pure ground-glass opacity (GGO) are increasing with the use of computed tomography (CT). In some cases, pure GGO on follow-up CT may represent tumor enlargement or the presence of solid components. We evaluated the natural progression of pure GGO lesions during a long-term follow-up period of more than 2 years. Methods: We retrospectively investigated 95 patients with pure GGO lesions detected between February 2003 and December 2010, in whom these lesions were monitored using CT for more than 2 years. Results: The median follow-up period was 64.7 months (range, 24–114 months). During the follow-up period, areas showing GGO increased in size or appeared to have solid components in 49 patients (group 1) and showed no change in 46 patients (group 2). We compared patient characteristics and tumor properties between the 2 groups. Mean CT attenuation values of the tumors differed significantly between groups 1 (-639.9 ± 88.9 HU) and 2 (-709.2 ± 60.9 HU). In contrast, no significant differences were noted with regard to age, gender, smoking history, lung cancer history, tumor size, and total numbers of GGO lesions between the 2 groups. The difference in the time to tumor growth according to the initial mean CT attenuation value was estimated using the Kaplan–Meier method. The growth incidence at 114 months for lesions with a mean CT attenuation value of -650 HU or more (n = 35) and less than -650 HU (n = 60) were estimated to be 96% and 48%, respectively. The difference between the 2 Kaplan–Meier curves was statistically significant (p < 0.0001). The usefulness of the mean CT attenuation value in predicting the growth of GGO lesions was evaluated using receiver operating characteristic analysis. The sensitivity and specificity was 63% and 87%, respectively, for a mean CT attenuation cutoff value of -650 HU. The area under the curve was 0.76. Conclusions: Many pure GGO lesions have potential for growth as seen during long-term follow-up. CT attenuation is useful in predicting the growth of GGO lesions.


2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Tommaso Testa ◽  
Federico Costanzo

Introduction. In the last years many mini-invasive approaches were developed in order to reduce postoperative pain and complication after haemorrhoid surgery: one of these alternatives is represented by Hemorpex System, a relatively young technique that combines transanal dearterialization with mucopexy through a dedicated proctoscope. Case Presentation. A 78-year-old male patient was admitted to the Emergency Department for acute urinary retention and elevated temperature. Hemorpex procedure was performed 4 years before. Clinical, endoscopic, and radiological findings demonstrated the presence of multiple diverticula-like structures fulfilled by purulent fluid and a deep alteration of the normal anatomy of the rectum. He was treated following the standard protocol of acute diverticulitis and full recovery from symptoms was achieved. Discussion. Hemorpex System is a young technique, and nowadays-available studies lack long-term follow-up data. Anatomical changes induced by the procedure are consistent and definitive. Our patient luckily demonstrated a prompt response to conservative treatment, but it must be taken into account that, in case of medical treatment failure, surgical approach would be necessary and the actual patient anatomical changes could lead the surgeon to unavoidable threatening maneuvers.


2005 ◽  
Vol 33 (3) ◽  
pp. 193-199 ◽  
Author(s):  
Shoichi KATO ◽  
Hiroshi YONEDA ◽  
Hideyuki ISHIHARA ◽  
Sadahiro NOMURA ◽  
Koji KAJIWARA ◽  
...  

2019 ◽  
Vol 61 (2) ◽  
pp. 175-183
Author(s):  
Hai Xu ◽  
Xue-Hui Pu ◽  
Tong-Fu Yu ◽  
Hai-Bin Shi ◽  
Yan-Ling Wu ◽  
...  

Background Increased use of thin-section computed tomography (CT) scans has revealed that small lung nodules, termed ground-glass nodules, are frequent in primary breast cancer patients and are associated with pre-invasive or invasive pulmonary adenocarcinomas. However, little is known of the incidence and fate of ground-glass nodules. Purpose To elucidate the incidence and natural course of CT-detected pulmonary ground-glass nodules in Chinese women with breast cancer. Material and Methods We retrospectively reviewed data from female breast cancer patients who underwent lung CT scans and who were followed for ≥3 months after the initial scan to identify the incidence of ground-glass nodules and any changes in them during the follow-up period. Results Between January 2008 and April 2018, 693 out of 4682 breast cancer patients (14.8%) had persistent lung ground-glass nodules as detected by CT scan. The median age was 52 years (interquartile range [IQR] = 45–62 years). Median nodule size was 4.9 mm in diameter on initial CT scan. Frequency of growth was 7.5% (52/693 patients). Median volume doubling time was 1092 days (IQR = 719–1808 days) for 39 growing in size nodules. Initial nodule size, nodule type, and follow-up period were independent predictors of nodule growth. Conclusion Most pulmonary ground-glass nodules in breast cancer patients were stable during long-term follow-up; most growing nodules had an indolent clinical course, suggesting that nodules should be monitored until growth is detected. This information is clinically relevant for accurate diagnosis of cancer stage and for appropriate treatment plans for patients with lung ground-glass nodules.


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