New promising antimicrobial material based on thermoplastic polyurethane modified with polymeric biocide polyhexamethylene guanidine hydrochloride

Выполнены реологические, структурные и антибактериальные исследования гидрогелей, получаемых на основе L-цистеина, ацетата серебра и полигексаметиленгуанидин гидрохлорида (ПГМГ-ГХ). Установлено, что водные растворы на основе L-цистеина и ацетата серебра хорошо смешиваются с водным раствором ПГМГ-ГХ, образуя прозрачные гидрогели. Предложена модель строения пространственной сетки геля. Показана высокая антимикробная активность гидрогеля по отношению к тест-культурам патогенных и условно-патогенных микроорганизмов. Rheological, structural, and antibacterial studies of hydrogels based on L-cysteine, silver acetate, and polyhexamethylene guanidine hydrochloride (PHMG-GC) have been carried out. It was found that aqueous solutions based on L-cysteine and silver acetate mix well with an aqueous solution of PHMG-GC, forming transparent hydrogels. A model of the structure of the spatial grid of the gel is proposed. High antimicrobial activity of the hydrogel was shown in relation to test cultures of pathogenic and opportunistic microorganisms.

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SYNTHESIS AND STUDY OF THE ANTIMICROBIAL ACTIVITY OF POLYHEXAMETHYLENE GUANIDINE HYDROCHLORIDE DERIVATIVES

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES ◽

10.37747/2312-640x-2020-18-67-69 ◽

2020 ◽

pp. 67-69

Author(s):

S. Stelmakh ◽

M. Grigor’eva ◽

N. Garkusheva ◽

D. Mognonov ◽

V. Batoev

Keyword(s):

Antimicrobial Activity ◽

Nosocomial Infections ◽

Guanidine Hydrochloride ◽

Polyhexamethylene Guanidine ◽

Derivatives Of

N-phenyl- and N-octyl-substituted derivatives of polyhexamethylene guanidine hydrochloride were synthesized and their antimicrobial activity against nosocomial infections was determined.

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Antibacterial, chemical and physical properties of sealants with polyhexamethylene guanidine hydrochloride

Brazilian Oral Research ◽

10.1590/1807-3107bor-2019.vol33.0019 ◽

2019 ◽

Vol 33 ◽

Cited By ~ 5

Author(s):

Isadora Martini GARCIA ◽

Stéfani Becker RODRIGUES ◽

Vicente Castelo Branco LEITUNE ◽

Fabrício Mezzomo COLLARES

Keyword(s):

Physical Properties ◽

Guanidine Hydrochloride ◽

Polyhexamethylene Guanidine

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Immunohistochemical characterization of oxidative stress in the lungs of rats exposed to the humidifier disinfectant polyhexamethylene guanidine hydrochloride

Journal of Toxicologic Pathology ◽

10.1293/tox.2019-0049 ◽

2019 ◽

Vol 32 (4) ◽

pp. 311-317 ◽

Cited By ~ 3

Author(s):

Yong-Hoon Lee ◽

Dong-Seok Seo ◽

Mi Ju Lee ◽

Hyo-Geun Cha

Keyword(s):

Oxidative Stress ◽

Guanidine Hydrochloride ◽

Polyhexamethylene Guanidine

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Development of non-leaching and eco-friendly polyhexamethylene guanidine hydrochloride based antimicrobial waterborne polyacrylates

Pigment & Resin Technology ◽

10.1108/prt-03-2017-0023 ◽

2017 ◽

Vol 46 (6) ◽

pp. 458-468

Author(s):

Wei Ding ◽

Kaimei Peng ◽

Tao Zou ◽

Ruonan Wang ◽

Jinshan Guo ◽

...

Keyword(s):

Molecular Weight ◽

Antibacterial Activity ◽

Guanidine Hydrochloride ◽

Antibacterial Properties ◽

Vinyl Monomer ◽

Diffusion Method ◽

Content Type ◽

Molecular Weights ◽

Polyhexamethylene Guanidine ◽

Antimicrobial Films

Purpose The purpose of this paper is to develop non-leaching and eco-friendly antimicrobial waterborne polyacrylates with excellent antibacterial properties by grafting antibacterial vinyl monomer, glycidyl methacrylate (GMA) modified polyhexamethylene guanidine hydrochloride (PHMG). Design/methodology/approach PHMG of different molecular weights were modified by GMA to synthesize antibacterial vinyl monomer, GMA-modified PHMG (GPHMG). Different content and molecular weights of GPHMG were used to synthesize antimicrobial waterborne polyacrylates through emulsion polymerization. Findings The addition of GPHMG gained by modifying PHMG showed little influence on thermal stability of the films, but decreased the glass transition temperature(Tg). Meanwhile, the tensile strength decreased, while the breaking elongation increased. The antibacterial properties of the antibacterial films with different GPHMG contents were studied, when GPHMG content was around 0.9 Wt.%, antibacterial films showed excellent antibacterial activity (antibacterial rate >= 99.99 per cent). When weight content of GPHMG in the films remained constant, antibacterial property of films increased first and then decreased with the increase of molecular weight of GPHMG. The structural antibacterial polymer film had more perdurable antibacterial activity than the blended one. Research limitations/implications The grafting efficiency of GPHMG to antimicrobial waterborne polyacrylates could be further improved. Practical implications Antimicrobial waterborne polyacrylates with excellent antibacterial properties can be used to antibacterial coating and adhesive. Originality/value The antibacterial properties of films with different molecular weight of GPHMG were studied, and the durability and stability of antibacterial properties between structural antimicrobial films and blended antimicrobial films were also investigated by ring-diffusion method.

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