A Novel Nanocomposite Platform of Mercaptopropionic acid stabilized CdSe quantum dots-Graphene for Impedimetric Detection of Low Density Lipoprotein

2021 ◽  
pp. 131236
Author(s):  
Drishti Khandelwal ◽  
Disha Jain ◽  
Pratima R Solanki ◽  
Kumar Rakesh Ranjan ◽  
Maumita Das Mukherjee
Keyword(s):  
Quantum Dots ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cdse Quantum Dots ◽  
Low Density ◽  
Mercaptopropionic Acid

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

Von der Diät bis zu Lipoproteinapherese

2020 ◽  
Vol 24 (09) ◽  
pp. 345-348
Author(s):  
Volker J.J. Schettler
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Kardiovaskuläre Ereignisse

Es ist unstrittig, dass eine erhöhte LDL-C-Konzentration (LDL-C: Low-Density-Lipoprotein-Cholesterin) ein kausaler Risikofaktor für kardiovaskuläre Ereignisse ist 1. Es ist daher nachvollziehbar, wenn mit einer therapeutischen LDL-C-Absenkung auch parallel weitere kardiovaskuläre Ereignisse vermindert werden 2. Interessant ist dabei, dass offensichtlich weniger der therapeutische Weg der LDL-C-Absenkung, sondern primär die so erreichte LDL-C-Konzentration, der LDL-C-Zielwert, zu einer Reduktion von kardiovaskulären Ereignissen führt 3.

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