Friction and wear of materials with additional deformation or stress is not a broadly described case. However, scientific publications considering this issue point out that additional deformation and stress ought to be taken into account during wear and friction analysis. In this article, the influence of strain in thermoplastics (POM, PTFE, PE-HD, PMMA) over the friction coefficient is described. Materials were deformed under tensile stress and examined after 24 hours. For specimens in which plastic strain was maintained, the decline of hardness (PE-HD: approximately 70% decrease, PTFE: approximately 40% decrease) and the reduction of the coefficient of kinetic friction (both PTFE and PE-HD: about 20% decrease) were observed. POM returned to its pre-deformed shape and PMMA was deformed without reaching its elastic limit. In these cases, only small changes in hardness (POM: approximately 10% decrease, PMMA: approximately 6% increase) and friction coefficients (maximum 4% change) occurred.