Updating gender differences in the control of homeostatic and hedonic food intake: Implications for binge eating disorder

2019 ◽  
Vol 497 ◽  
pp. 110508 ◽  
Author(s):  
Marta G. Novelle ◽  
Carlos Diéguez
Keyword(s):  
Gender Differences ◽  
Eating Disorder ◽  
Food Intake ◽  
Binge Eating ◽  
Binge Eating Disorder

scholarly journals Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder

2020 ◽  
Vol 45 (11) ◽  
pp. 1931-1941 ◽  
Author(s):  
Adele Romano ◽  
Maria Vittoria Micioni Di Bonaventura ◽  
Cristina Anna Gallelli ◽  
Justyna Barbara Koczwara ◽  
Dorien Smeets ◽  
...  
Keyword(s):  
Eating Disorder ◽  
Nucleus Accumbens ◽  
Food Intake ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Female Rats ◽  
Early Gene ◽  
Mrna Levels ◽  
Palatable Food ◽  
Brain Areas

Abstract Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus highlighting the need for novel treatment options. The lipid-derived messenger oleoylethanolamide (OEA) acts as a satiety signal inhibiting food intake through the involvement of central noradrenergic and oxytocinergic neurons. We investigated the anti-binge effects of OEA in a rat model of binge-like eating, in which, after cycles of intermittent food restrictions/refeeding and palatable food consumptions, female rats show a binge-like intake of palatable food, following a 15-min exposure to their sight and smell (“frustration stress”). Systemically administered OEA dose-dependently (2.5, 5, and 10 mg kg−1) prevented binge-like eating. This behavioral effect was associated with a decreased activation (measured by mapping the expression of c-fos, an early gene widely used as a marker of cellular activation) of brain areas responding to stress (such as the nucleus accumbens and amygdala) and to a stimulation of areas involved in the control of food intake, such as the VTA and the PVN. These effects were paralleled, also, to the modulation of monoamine transmission in key brain areas involved in both homeostatic and hedonic control of eating. In particular, a decreased dopaminergic response to stress was observed by measuring dopamine extracellular concentrations in microdialysates from the nucleus accumbens shell, whereas an increased serotonergic and noradrenergic tone was detected in tissue homogenates of selected brain areas. Finally, a decrease in corticotropin-releasing factor (CRF) mRNA levels was induced by OEA in the central amygdala, while an increase in oxytocin mRNA levels was induced in the PVN. The restoration of a normal oxytocin receptor density in the striatum paralleled the oxytocinergic stimulation produced by OEA. In conclusion, we provide evidence suggesting that OEA might represent a novel potential pharmacological target for the treatment of binge-like eating behavior.

Feeding and Eating Disorders

2017 ◽  
Author(s):  
Patricia Westmoreland ◽  
Phillip S Mehler
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Food Intake ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Restrictive Eating ◽  
Dsm 5 ◽  
Feeding And Eating Disorders

Feeding and eating disorders are defined by persistent disturbance of eating (or behaviors related to eating) with subsequent changes in consumption or absorption of nutrition that are detrimental to physical health and social functioning. The following eating disorders are described in the DSM-5: anorexia nervosa, bulimia nervosa, binge eating disorder, pica, rumination disorder, avoidant/restrictive food intake disorder (ARFID), other specified feeding or eating disorder (OSFED), and unspecified feeding or eating disorder (USFED). ARFID, OSFED, USFED, rumination disorder, and binge eating disorder are new additions to the manual and are first described in the DSM-5. The DSM-5 also provides severity specifiers—mild, moderate, severe, and extreme—for the diagnoses of bulimia nervosa and anorexia nervosa. This review describes the eating disorders enumerated in the DSM-5 and provides information regarding their genesis and course. This review contains 8 tables and 79 references Key words: avoidant/restrictive eating disorder, binge eating disorder, DSM-5, eating disorder, other specified feeding or eating disorder, pharmacotherapy, pica rumination, psychotherapy, unspecified feeding or eating disorder

scholarly journals Binge Eating Disorder Mediates Links between Symptoms of Depression, Anxiety, and Caloric Intake in Overweight and Obese Women

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Roseann E. Peterson ◽  
Shawn J. Latendresse ◽  
Lindsay T. Bartholome ◽  
Cortney S. Warren ◽  
Nancy C. Raymond
Keyword(s):  
Eating Disorder ◽  
Food Intake ◽  
Binge Eating ◽  
Path Analysis ◽  
Binge Eating Disorder ◽  
Internalizing Symptoms ◽  
Depression And Anxiety ◽  
Obese Women ◽  
Effective Prevention ◽  
Symptoms Of Depression

Despite considerable comorbidity between mood disorders, binge eating disorder (BED), and obesity, the underlying mechanisms remain unresolved. Therefore, the purpose of this study was to examine models by which internalizing behaviors of depression and anxiety influence food intake in overweight/obese women. Thirty-two women (15 BED, 17 controls) participated in a laboratory eating-episode and completed questionnaires assessing symptoms of anxiety and depression. Path analysis was used to test mediation and moderation models to determine the mechanisms by which internalizing symptoms influenced kilocalorie (kcal) intake. The BED group endorsed significantly more symptoms of depression (10.1 versus 4.8,P=0.005) and anxiety (8.5 versus 2.7,P=0.003). Linear regression indicated that BED diagnosis and internalizing symptoms accounted for 30% of the variance in kcal intake. Results from path analysis suggested that BED mediates the influence of internalizing symptoms on total kcal intake (empiricalP<0.001). The associations between internalizing symptoms and food intake are best described as operating indirectly through a BED diagnosis. This suggests that symptoms of depression and anxiety influence whether one engages in binge eating, which influences kcal intake. Greater understanding of the mechanisms underlying the associations between mood, binge eating, and food intake will facilitate the development of more effective prevention and treatment strategies for both BED and obesity.

Gender differences in patients with binge eating disorder

2001 ◽  
Vol 31 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Declan T. Barry ◽  
Carlos M. Grilo ◽  
Robin M. Masheb
Keyword(s):  
Gender Differences ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder

Feeding and Eating Disorders

2017 ◽  
Author(s):  
Patricia Westmoreland ◽  
Phillip S Mehler
Keyword(s):  
Eating Disorders ◽  
Anorexia Nervosa ◽  
Eating Disorder ◽  
Food Intake ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Restrictive Eating ◽  
Dsm 5 ◽  
Feeding And Eating Disorders

Feeding and eating disorders are defined by persistent disturbance of eating (or behaviors related to eating) with subsequent changes in consumption or absorption of nutrition that are detrimental to physical health and social functioning. The following eating disorders are described in the DSM-5: anorexia nervosa, bulimia nervosa, binge eating disorder, pica, rumination disorder, avoidant/restrictive food intake disorder (ARFID), other specified feeding or eating disorder (OSFED), and unspecified feeding or eating disorder (USFED). ARFID, OSFED, USFED, rumination disorder, and binge eating disorder are new additions to the manual and are first described in the DSM-5. The DSM-5 also provides severity specifiers—mild, moderate, severe, and extreme—for the diagnoses of bulimia nervosa and anorexia nervosa. This review describes the eating disorders enumerated in the DSM-5 and provides information regarding their genesis and course. This review contains 8 tables and 79 references Key words: avoidant/restrictive eating disorder, binge eating disorder, DSM-5, eating disorder, other specified feeding or eating disorder, pharmacotherapy, pica rumination, psychotherapy, unspecified feeding or eating disorder

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