scholarly journals Validation of Predictors of Disease Severity and Outcomes in COVID-19 Patients: A Descriptive and Retrospective Study

Med ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 128-138.e3 ◽  
Author(s):  
Li Tan ◽  
Xia Kang ◽  
Xinran Ji ◽  
Gaoming Li ◽  
Qi Wang ◽  
...  
2021 ◽  
Vol 8 (4) ◽  
pp. 461-464
Author(s):  
Vineet Banga ◽  
Stuti Jain

Patients of Covid 19 infections present with different severity. Levels of D Dimer in these patients can be correlated with disease severity for management and prognosis. To evaluate the usefulness of D-Dimer levels in blood to correlate with disease severity in COVID 19 patients. Retrospective study was done in Department of Pathology of Secondary Care hospital that became designated covid hospital from May 2021 to June 2021 on 60 COVID 19 positive admitted patients. D dimer levels were analysed and correlated with clinical severity of disease. Out of total 60 patients, 33 were in mild, 23 in moderate and 4 were in severe category. In mild cases D Dimer varies from 43 ng/ml to 183 ng/ml. In moderate cases D Dimer varies from 270 ng/ml to 991 ng/ml. In severe cases D Dimer varies from 1043 ng/ml to 2463 ng/ml. The study suggests cut off levels for D Dimer as up to 200 ng/ml for mild, 200-1000 ng/ml for moderate and more than 1000 ng/ml for severe category in COVID 19 patients. D dimer helps in identifying severe disease and can be used as an essential biomarker in developing the management protocol for COVID 19 patients.


BDJ ◽  
2005 ◽  
Vol 198 (8) ◽  
pp. 495-498 ◽  
Author(s):  
M Razali ◽  
R M Palmer ◽  
P Coward ◽  
R F Wilson

2020 ◽  
Vol 222 (11) ◽  
pp. 1789-1793 ◽  
Author(s):  
Christophe Guervilly ◽  
Stephane Burtey ◽  
Florence Sabatier ◽  
Raphaël Cauchois ◽  
Guillaume Lano ◽  
...  

Abstract Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.


2014 ◽  
Vol 71 (3) ◽  
pp. 460-467 ◽  
Author(s):  
Anne M.R. Schrader ◽  
Inge E. Deckers ◽  
Hessel H. van der Zee ◽  
Jurr Boer ◽  
Errol P. Prens

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