Activation of the intracellular temperature and ROS sensor membrane protein STIM1 as a mechanism underpinning biological effects of low-level low frequency magnetic fields

2019 ◽  
Vol 122 ◽  
pp. 68-72 ◽  
Author(s):  
Myrtill Simkó ◽  
Mats-Olof Mattsson
Keyword(s):  
Magnetic Fields ◽  
Membrane Protein ◽  
Biological Effects ◽  
Low Frequency ◽  
Low Level ◽  
Sensor Membrane

scholarly journals Induction of micronuclei and superoxide production in neuroblastoma and glioma cell lines exposed to weak 50 Hz magnetic fields

2016 ◽  
Vol 13 (114) ◽  
pp. 20150995 ◽  
Author(s):  
Kavindra Kumar Kesari ◽  
Jukka Juutilainen ◽  
Jukka Luukkonen ◽  
Jonne Naarala
Keyword(s):  
Magnetic Fields ◽  
Cell Lines ◽  
Biological Effects ◽  
Low Frequency ◽  
Epidemiological Studies ◽  
Dna Integrity ◽  
C6 Cells ◽  
Adverse Health Effects ◽  
Mitochondrial Superoxide ◽  
Exposure Response

Extremely low-frequency (ELF) magnetic fields (MF) have been associated with adverse health effects in epidemiological studies. However, there is no known mechanism for biological effects of weak environmental MFs. Previous studies indicate MF effects on DNA integrity and reactive oxygen species, but such evidence is limited to MFs higher (greater than or equal to 100 µT) than those generally found in the environment. Effects of 10 and 30 µT fields were studied in SH-SY5Y and C6 cells exposed to 50-Hz MFs for 24 h. Based on earlier findings, menadione (MQ) was used as a cofactor. Responses to MF were observed in both cell lines, but the effects differed between the cell lines. Micronuclei were significantly increased in SH-SY5Y cells at 30 µT. This effect was largest at the highest MQ dose used. Increased cytosolic and mitochondrial superoxide levels were observed in C6 cells. The effects on superoxide levels were independent of MQ, enabling further mechanistic studies without co-exposure to MQ. The micronucleus and mitochondrial superoxide data were consistent with a conventional rising exposure–response relationship. For cytosolic superoxide, the effect size was unexpectedly large at 10 µT. The results indicate that the threshold for biological effects of ELF MFs is 10 µT or less.

scholarly journals Comparative Analysis of Biological Effects Induced on Different Cell Types by Magnetic Fields with Magnetic Flux Densities in the Range of 1–60 mT and Frequencies up to 50 Hz

2018 ◽  
Vol 10 (8) ◽  
pp. 2776 ◽  
Author(s):  
Cristian Vergallo ◽  
Luciana Dini
Keyword(s):  
Magnetic Fields ◽  
Magnetic Flux ◽  
Transmission Lines ◽  
Bystander Effect ◽  
Human Peripheral Blood ◽  
Biological Effects ◽  
Low Frequency ◽  
Cell Types ◽  
Peripheral Blood Lymphocytes ◽  
Different Cell Types

Moderate static magnetic fields (SMFs) are generated from sources such as new-generation electric trams and trains, electric arc welding, and magnetic resonance imaging (MRI) devices, as well as during the industrial production of aluminium, while extremely low frequency pulsed magnetic fields (ELF-PMFs) are produced by house power installations, household appliances, and high voltages transmission lines. Moderate SMFs and ELF-PMFs with magnetic flux densities (B) in the range of 1–60 mT and frequencies (f) up to 50 Hz are common MF exposure sources for the population. Even though humans are continually exposed to these MFs, to date no definitive endpoint has been drawn about their safety. In this review, the state of knowledge about the biological effects induced by these MFs on different cell types will be addressed. In our own observation, the putative modulation of Ca2+/H+ and Na+/H+ plasma membrane antiporters of human peripheral blood lymphocytes (PBLs) was found to occur after a 24 h exposure to a 6 mT SMF, and the bystander effect observed on U937 cells cultivated for up to 6 h in the conditioned medium harvested from human PBLs previously exposed for 24 h to the same MF (secondary necrosis induction) will be also herein discussed.

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