Prolonged functional cerebral asymmetry as a consequence of dysfunctional parvocellular paraventricular hypothalamic nucleus signaling: An integrative model for the pathophysiology of bipolar disorder

2020 ◽  
pp. 110433
Author(s):  
Kate Levenberg ◽  
Andras Hajnal ◽  
Daniel R. George ◽  
Erika F.H. Saunders
Keyword(s):  
Bipolar Disorder ◽  
Integrative Model ◽  
Hypothalamic Nucleus ◽  
Cerebral Asymmetry ◽  
Paraventricular Hypothalamic Nucleus

Bilateral lesions of the paraventricular hypothalamic nucleus disrupt nursing behavior in rabbits

2017 ◽  
Vol 46 (5) ◽  
pp. 2133-2140 ◽  
Author(s):  
Miguel Domínguez ◽  
Raúl Aguilar‐Roblero ◽  
Gabriela González‐Mariscal
Keyword(s):  
Hypothalamic Nucleus ◽  
Paraventricular Hypothalamic Nucleus ◽  
Bilateral Lesions

Age-dependent overflow of endogenous norepinephrine from paraventricular hypothalamic nucleus of hypertensive rats

1993 ◽  
Vol 265 (1) ◽  
pp. H39-H46 ◽  
Author(s):  
J. M. Qualy ◽  
T. C. Westfall
Keyword(s):  
Blood Pressure ◽  
Neuronal Activity ◽  
Reciprocal Relationship ◽  
Hypothalamic Nucleus ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Paraventricular Hypothalamic Nucleus ◽  
Wistar Kyoto ◽  
The Relationship

The relationship between age and central noradrenergic neuronal activity of the paraventricular hypothalamic nucleus (PVH) was examined in 7- to 10-, 12- to 14-, and 30- to 36-wk-old Sprague-Dawley (SD), Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR). As an index of noradrenergic activity, endogenous norepinephrine (NE) overflow was assessed utilizing a miniaturized push-pull cannula assembly in unanesthetized freely moving rats. NE overlow under basal, 56 mM K+ stimulation, and in response to pressor/depressor drugs, were examined in all three strains at all ages. Significant increases in basal and K(+)-stimulated overflow of endogenous NE from the PVH were observed in all ages of SHR compared with normotensive controls with the greatest percent increase occurring during the development of hypertension in SHR. In addition, a reciprocal relationship exists with respect to blood pressure and overflow of NE from the PVH such that increases/decreases in blood pressure elicit decreases/increases in NE overflow in all strains at all ages examined. However, developing hypertensive SHR exhibited attenuated decreases in overflow of NE from the PVH compared with age-matched controls and established hypertensive SHR. These results suggest that noradrenergic pathways of the PVH contribute to the development and maintenance of arterial pressure hemostasis and that enhanced central noradrenergic neuronal activity is greatest during the development of hypertension in SHR.

Paraventricular hypothalamic nucleus stimulation modulates nociceptive responses in dorsal horn wide dynamic range neurons

2008 ◽  
Vol 444 (2) ◽  
pp. 199-202 ◽  
Author(s):  
Miguel Condés-Lara ◽  
Guadalupe Martínez-Lorenzana ◽  
Javier Rodríguez-Jiménez ◽  
Gerardo Rojas-Piloni
Keyword(s):  
Dorsal Horn ◽  
Dynamic Range ◽  
Hypothalamic Nucleus ◽  
Wide Dynamic Range ◽  
Paraventricular Hypothalamic Nucleus ◽  
Nociceptive Responses ◽  
Wide Dynamic Range Neurons

scholarly journals Paraventricular hypothalamic nucleus: Axonal projections to the brainstem

2010 ◽  
Vol 518 (9) ◽  
pp. 1460-1499 ◽  
Author(s):  
Joel C. Geerling ◽  
Jung-Won Shin ◽  
Peter C. Chimenti ◽  
Arthur D. Loewy
Keyword(s):  
Hypothalamic Nucleus ◽  
Paraventricular Hypothalamic Nucleus ◽  
Axonal Projections
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