Nanostructured silver materials for noninvasive medical diagnostics by surface-enhanced Raman spectroscopy

2016 ◽  
Vol 26 (3) ◽  
pp. 177-186 ◽  
Author(s):  
Anna A. Semenova ◽  
Alexander P. Semenov ◽  
Elena A. Gudilina ◽  
Galina T. Sinyukova ◽  
Nadezhda A. Brazhe ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Medical Diagnostics ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Promising methods for noninvasive medical diagnosis based on the use of nanoparticles: surface-enhanced raman spectroscopy in the study of cells, cell organelles and neurotransmitter metabolism markers

2018 ◽  
pp. 57-67
Author(s):  
E.A. Goodilin ◽  
A.A. Semenova ◽  
O.E. Eremina ◽  
N.A. Brazhe ◽  
E.A. Goodilinа ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Medical Diagnostics ◽  
Optical Methods ◽  
Optical Systems ◽  
Noble Metal Nanoparticles ◽  
Cell Organelles ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Neurotransmitter Metabolism

Application of advances in nanomedicine and materials science to medical diagnostics is a promising area of research. Surface-enhanced Raman spectroscopy (SERS) is an innovative analytical method that exploits noble metal nanoparticles to noninvasively study cells, cell organelles and protein molecules. Below, we summarize the literature on the methods for early clinical diagnosis of some neurodegenerative and neuroendocrine diseases. We discuss the specifics, advantages and limitations of different diagnostic techniques based on the use of low- and high molecular weight biomarkers. We talk about the prospects of optical methods for rapid diagnosis of neurotransmitter metabolism disorders. Special attention is paid to new approaches to devising optical systems that expand the analytical potential of SERS, the tool that demonstrates remarkable sensitivity, selectivity and reproducibility of the results in determining target analytes in complex biological matrices.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

Sign in / Sign up

Export Citation Format

Share Document