Phosphite-containing iridium polarization transfer catalysts for NMR signal amplification by reversible exchange

2021 ◽  
Vol 31 (4) ◽  
pp. 475-477
Author(s):  
Kirill A. Spiridonov ◽  
Vitaly P. Kozinenko ◽  
Igor A. Nikovsky ◽  
Alexander A. Pavlov ◽  
Tatyana N. Vol'khina ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Polarization Transfer

scholarly journals Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug Candidates

2020 ◽  
Author(s):  
HyeJin Jeong ◽  
Sein Min ◽  
Heelim Chae ◽  
Sara Kim ◽  
Gunwoo Lee ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Signal Amplification ◽  
Antiviral Drug ◽  
Polarization Transfer ◽  
Future Research ◽  
Resonance Imaging ◽  
Long Distance ◽  
Isotope Labelling ◽  
Drug Candidates ◽  
Molecular Scale

<p></p><p>Several drug candidates have been proposed and tested as the latest clinical treatment for the coronavirus pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are proved to be effective after treatment. The hyperpolarization technique presents an ability to further understand the roles of these drugs at the molecular scale and applications in nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI). This technique may provide new opportunities in diagnosis and biomedical research to cope with COVID-19. Signal amplification by reversible exchange (SABRE)-based hyperpolarization studies on large-sized drug candidates were carried out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented long-distance polarization transfer by <i>para</i>-hydrogen. We also found that the optimum magnetic field for the maximum polarization transfer yield was dependent on the molecular structure. Therefore, future research on isotope labelling and polarization transfer on long T1 time nuclei including clinical perspectives can help us overcome this worldwide pandemic.</p><p></p>

scholarly journals Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3347 ◽  
Author(s):  
Sarah Kim ◽  
Sein Min ◽  
Heelim Chae ◽  
Hye Jin Jeong ◽  
Sung Keon Namgoong ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Spin Polarization ◽  
Signal Amplification ◽  
Polarization Transfer ◽  
Nitrile Group ◽  
Structural Isomers ◽  
Sequential Study ◽  
Effective Polarization ◽  
Branched Structures ◽  
Transfer Mechanisms

Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from parahydrogen. In this study, we systemically applied SABRE to a series of nitrile compounds, which have been rarely investigated. By performing SABRE in various magnetic fields and concentrations on nitrile compounds, we unveiled its hyperpolarization properties to maximize the spin polarization and its transfer to the next spins. Through this sequential study, we obtained a ~130-fold enhancement for several nitrile compounds, which is the highest number ever reported for the nitrile compounds. Our study revealed that the spin polarization on hydrogens decreases with longer distances from the nitrile group, and its maximum polarization is found to be approximately 70 G with 5 μL of substrates in all structures. Interestingly, more branched structures in the ligand showed less effective polarization transfer mechanisms than the structural isomers of butyronitrile and isobutyronitrile. These first systematic SABRE studies on a series of nitrile compounds will provide new opportunities for further research on the hyperpolarization of various useful nitrile materials.

scholarly journals Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug Candidates

2020 ◽  
Author(s):  
HyeJin Jeong ◽  
Sein Min ◽  
Heelim Chae ◽  
Sara Kim ◽  
Gunwoo Lee ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Signal Amplification ◽  
Antiviral Drug ◽  
Polarization Transfer ◽  
Future Research ◽  
Resonance Imaging ◽  
Long Distance ◽  
Isotope Labelling ◽  
Drug Candidates ◽  
Molecular Scale

<p></p><p>Several drug candidates have been proposed and tested as the latest clinical treatment for the coronavirus pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are proved to be effective after treatment. The hyperpolarization technique presents an ability to further understand the roles of these drugs at the molecular scale and applications in nuclear magnetic resonance/magnetic resonance imaging (NMR/MRI). This technique may provide new opportunities in diagnosis and biomedical research to cope with COVID-19. Signal amplification by reversible exchange (SABRE)-based hyperpolarization studies on large-sized drug candidates were carried out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented long-distance polarization transfer by <i>para</i>-hydrogen. We also found that the optimum magnetic field for the maximum polarization transfer yield was dependent on the molecular structure. Therefore, future research on isotope labelling and polarization transfer on long T1 time nuclei including clinical perspectives can help us overcome this worldwide pandemic.</p><p></p>

Analysis of 1-aminoisoquinoline using the signal amplification by reversible exchange hyperpolarization technique

The Analyst ◽  
2020 ◽  
Vol 145 (20) ◽  
pp. 6478-6484 ◽  
Author(s):  
Hye Jin Jeong ◽  
Sein Min ◽  
Keunhong Jeong
Keyword(s):  
Density Functional Theory ◽  
Dft Calculations ◽  
Signal Amplification ◽  
Density Functional ◽  
Polarization Transfer ◽  
Transfer Mechanism ◽  
Functional Theory ◽  
Solvent Systems

1-aminoisoquinoline (1-AIQ), is successfully hyperpolarized in diverse solvent systems using SABRE. Additionally, the polarization transfer mechanism of 1-AIQ is explained by comparing to pyridine using density functional theory (DFT) calculations.

scholarly journals Chloroquine and Lopinavir (COVID-19 Drug Candidates) Signal Amplification by Reversible Exchange

2020 ◽  
Author(s):  
HyeJin Jeong ◽  
Sein Min ◽  
Heelim Chae ◽  
Sara Kim ◽  
Gunwoo Lee ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Isotope Labeling ◽  
Molecular Level ◽  
Polarization Transfer ◽  
Clinical Treatment ◽  
Future Application ◽  
Long Distance ◽  
Drug Candidates ◽  
Future Work

<p>To overcome the recent coronavirus pneumonia (COVID-19), several drug candidates are suggested and tested for the latest clinical treatment. Chloroquine and lopinavir are showing definite effects after treatment. To understand more about those roles in molecular level and future application on NMR/MRI, hyperpolarization technique can open new opportunities in the diagnosis and biomedical researches to cope with COVID-19. SABRE-based hyperpolarization studies on those two drug candidates are carried out and we observed hyperpolarized proton signals from the whole structures, which can be possible by unprecedented long-distance polarization transfer by <i>para</i>-hydrogen. Base on this result, future work on isotope labeling, and further polarization transfer on long T1 time nuclei including clinical perspectives will open a new door for overcoming this dreadful catastrophe.</p>

POLARIZATION TRANSFER IN ELASTIC p-d SCATTERING AT Ep=22.7 MeV

1990 ◽  
Vol 51 (C6) ◽  
pp. C6-451-C6-454
Author(s):  
W. GRÜEBLER ◽  
M. CLAJUS ◽  
P. M. EGUN ◽  
P. HAUTLE ◽  
A. WEBER ◽  
...  
Keyword(s):  
Polarization Transfer

Experimental Validation of Digital Pre-distortion Technique for Dual-band Dual-signal Amplification by Single Feedback Architecture Employing Dual-band Mixer

2015 ◽  
Vol E98.C (3) ◽  
pp. 242-251 ◽  
Author(s):  
Ikuma ANDO ◽  
Gia KHANH TRAN ◽  
Kiyomichi ARAKI ◽  
Takayuki YAMADA ◽  
Takana KAHO ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Experimental Validation ◽  
Dual Band ◽  
Dual Signal Amplification

Electrochemiluminescence Biosensor for Detection of Thrombin Using Enzyme-based Signal Amplification

2013 ◽  
Vol 40 (10) ◽  
pp. 1549-1554
Author(s):  
Hua-Yu ZHU ◽  
Li ZHANG ◽  
Huai-Cheng CHEN ◽  
Sheng-Juan YAN
Keyword(s):  
Signal Amplification
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