p38 MAPK signaling pathway activation by phenyl benzoxime in SNU-306 cells causes induction of apoptosis

2019 ◽  
Vol 126 ◽  
pp. 74-78 ◽  
Author(s):  
Wei Chen ◽  
Yanni Tan ◽  
Yu Zhang
Keyword(s):  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Pathway Activation ◽  
Induction Of Apoptosis

scholarly journals Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia

Renal Failure ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 903-910 ◽  
Author(s):  
LieMei Zhang ◽  
Ling Ji ◽  
XiaoHong Tang ◽  
XiaoLei Chen ◽  
Zi Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Pathway Activation

Role of p38 MAPK pathway in apoptosis induction by saturated fatty acid in human pancreatic β-cells

2016 ◽  
Vol 62 (5) ◽  
pp. 13-14
Author(s):  
Jan Šrámek ◽  
Vlasta Němcová-Fürstová ◽  
Kamila Balušíková ◽  
Petr Daniel ◽  
Michael Jelínek ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Erk Pathway ◽  
Apoptosis Induction ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Pathway Activation

Background. Pancreatic β-cells failure and apoptosis in response to chronically elevated concentrations of saturated fatty acids in blood was considered as one of the main causes of type 2 diabetes mellitus development. Although precise molecular mechanisms of this process are still unclear, there are some indications that the p38 MAPK signaling pathway could be involved.Aim, materials and methods. Therefore, we tested the role of p38 MAPK signaling pathway activation in apoptosis induction by SA in human pancreatic β-cells NES2Y. Crosstalk between p38 MAPK pathway activation and accompanying ERK pathway inhibition after SA application was also tested.Results. We have found that saturated SA at apoptosis-inducing concentration (1 mM) activated the p38 MAPK signaling pathway MKK3/6→p38 MAPK→MAPKAPK-2 and inhibited the ERK signaling pathway c-Raf→MEK1/2→ERK1/2. The inhibition of p38 MAPK expression by siRNA silencing had no significant effect on cell viability or the level of phosphorylated ERK pathway members after SA administration. The inhibition of p38 MAPK activity by the specific inhibitor SB202190 resulted in noticeable activation of ERK pathway members after SA treatment but in no significant effect on cell viability. p38 MAPK overexpression by plasmid transfection produced no significant influence on cell viability or ERK pathway activation after SA exposure. The activation of p38 MAPK by the specific activator anisomycin led to apoptosis induction similar to application of SA (PARP cleavage and caspase-7, -8, and -9 activation) and in inhibition of ERK pathway members.Conclusions. We demonstrated that apoptosis-inducing concentrations of SA activate the p38 MAPK signaling pathway and that this activation could be involved in apoptosis induction by SA in the human pancreatic β-cells NES2Y. However, this involvement does not seem to play a key role. Crosstalk between p38 MAPK pathway activation and ERK pathway inhibition in NES2Y cells seems likely. Thus, the ERK pathway inhibition by p38 MAPK activation does not also seem to be essential for SA-induced apoptosis.

Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells

2012 ◽  
Vol 33 (12) ◽  
pp. 1500-1505 ◽  
Author(s):  
Yu Sun ◽  
Shusheng Tang ◽  
Xi Jin ◽  
Chaoming Zhang ◽  
Wenxia Zhao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
S Phase ◽  
Mapk Signaling Pathway ◽  
Phase Cell ◽  
Human Hepatoma ◽  
Cycle Arrest

scholarly journals IFN-γ Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

2012 ◽  
Vol 189 (2) ◽  
pp. 813-818 ◽  
Author(s):  
Takeshi Matsuzawa ◽  
Bae-Hoon Kim ◽  
Avinash R. Shenoy ◽  
Shigeki Kamitani ◽  
Masami Miyake ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Ifn Γ
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