The three-stage in vitro degradation behavior of mesoporous silica in simulated body fluid

Biodegradable stenting and implantation materials have received considerable attention in biomaterials community, with magnesium having been received most wide attention. However, magnesium corrodes too fast by nature, in human body environment. A new type of biodegradable metal – Fe and its alloys – has been introduced in recent years. In this study, a Fe 35 wt % Mn alloy was produced using powder sintering. Powder mixture was mechanically milled, pressed and then sintered to consolidate powder compacts. Microstructure characterization and hardness measurement were carried out on the as-sintered samples. In vitro degradability evaluation of the samples was performed in 5% NaCl and Simulated Body Fluid (SBF) media. The experimental results show that a higher porosity results in a higher degradation rate. All samples, with porosity being from 6.5% to 12.2 %, revealed a degradation rate from 0.6 to 1.4 mm/year.

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Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid

Acta Biomaterialia ◽

10.1016/j.actbio.2010.09.013 ◽

2011 ◽

Vol 7 (2) ◽

pp. 829-840 ◽

Cited By ~ 54

Author(s):

J.J. Blaker ◽

S.N. Nazhat ◽

V. Maquet ◽

A.R. Boccaccini

Keyword(s):

Simulated Body Fluid ◽

Body Fluid ◽

In Vitro Degradation ◽

Bone Scaffolds

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Effects of Mechanical Stress on the In Vitro Degradation of Porous Composite Scaffold for Bone Tissue Engineering

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.342-343.273 ◽

2007 ◽

Vol 342-343 ◽

pp. 273-276 ◽

Cited By ~ 2

Author(s):

Yun Qing Kang ◽

Guang Fu Yin ◽

Lin Luo ◽

Ke Feng Wang ◽

Yu Zhang

Keyword(s):

Tissue Engineering ◽

Simulated Body Fluid ◽

Bone Tissue Engineering ◽

Mechanical Stress ◽

Mechanical Loading ◽

Body Fluid ◽

Compressive Loading ◽

Porous Scaffolds ◽

In Vitro Degradation

In bone tissue engineering, porous scaffolds served as the temporary matrix are often subjected to mechanical stress when implanted in the body. Based on this fact, the goal of this study was to examine the effects of mechanical loading on the in vitro degradation characteristics and kinetics of porous scaffolds in a custom-designed loading system. Porous Poly(L-lactic acid)/β-Tricalcium Phosphate (PLLA/β-TCP) composite scaffolds fabricated by using solution casting/compression molding/particulate leaching technique (SCP) were subjected to degradation in simulated body fluid (SBF) at 37°C for up to 6 weeks under the conditions: with and without static compressive loading, respectively. The results indicated that the increase of the porosity and decrease of the compressive strength under static compressive loading were slower than that of non-loading case, and so did the mass loss rate. It might be due to that the loading retarded the penetration, absorption and transfer of simulated body fluid. These data provide an important step towards understanding mechanical loading factors contributing to degradation.

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