DEGRADATION BEHAVIOR OF A BIODEGRADABLE Fe-Mn ALLOY PRODUCED BY POWDER SINTERING

2012 ◽  
Vol 06 ◽  
pp. 774-779
Author(s):  
QIAN ZHANG ◽  
X. G. Wang ◽  
PENG CAO ◽  
WEI GAO
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Degradation Rate ◽  
Hardness Measurement ◽  
Degradation Behavior ◽  
Biodegradable Metal ◽  
Powder Sintering ◽  
New Type ◽  
Powder Compacts

Biodegradable stenting and implantation materials have received considerable attention in biomaterials community, with magnesium having been received most wide attention. However, magnesium corrodes too fast by nature, in human body environment. A new type of biodegradable metal – Fe and its alloys – has been introduced in recent years. In this study, a Fe 35 wt % Mn alloy was produced using powder sintering. Powder mixture was mechanically milled, pressed and then sintered to consolidate powder compacts. Microstructure characterization and hardness measurement were carried out on the as-sintered samples. In vitro degradability evaluation of the samples was performed in 5% NaCl and Simulated Body Fluid (SBF) media. The experimental results show that a higher porosity results in a higher degradation rate. All samples, with porosity being from 6.5% to 12.2 %, revealed a degradation rate from 0.6 to 1.4 mm/year.

In Vitro and In Vivo Degradation, Mechanical Properties, and Histocompatibility of Weft-Knitted Silk Mesh-Like Grafts

2022 ◽  
Vol 12 (2) ◽  
pp. 411-416
Author(s):  
Liang Tang ◽  
Si-Yu Zhao ◽  
Ya-Dong Yang ◽  
Geng Yang ◽  
Wen-Yuan Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Degradation Rate ◽  
Maximum Load ◽  
Artificial Ligament ◽  
In Vivo Degradation

To investigate the degradation, mechanical properties, and histocompatibility of weft-knitted silk mesh-like grafts, we carried out the In Vitro and In Vivo silk grafts degradation assay. The In Vitro degradation experiment was performed by immersing the silk grafts in simulated body fluid for 1 year, and the results showed that the degradation rate of the silk mesh-like grafts was very slow, and there were few changes in the mechanical properties and quality of the silk mesh-like graft. In Vivo degradation assay was taken by implantation of the silk mesh-like grafts into the subcutaneous muscles of rabbits. At 3, 6, and 12 months postoperation, the rate of mass loss was 19.36%, 31.84%, and 58.77%, respectively, and the maximum load was 63.85%, 34.63%, and 10.76%, respectively of that prior to degradation. The results showed that the degradation rate of the silk graft and the loss of mechanical properties In Vivo were faster than the results obtained in the In Vitro experiments. In addition, there were no significant differences in secretion of serum IL-6 and TNF-α between the experimental and normal rabbits (P >0.05), suggesting no obvious inflammatory reaction. The findings suggest that the weft-knitted silk mesh-like grafts have good mechanical properties, histocompatibility, and In Vivo degradation rate, and therefore represent a candidate material for artificial ligament

In vitro degradation behavior of M1A magnesium alloy in protein-containing simulated body fluid

2011 ◽  
Vol 31 (3) ◽  
pp. 579-587 ◽  
Author(s):  
Yongsheng Wang ◽  
Chu Sing Lim ◽  
Chao Voon Lim ◽  
Ming Shyan Yong ◽  
Eng Kiong Teo ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Degradation Behavior ◽  
In Vitro Degradation

In Vitro Bioactivity Assessment of Metallic Magnesium

2006 ◽  
Vol 309-311 ◽  
pp. 453-456 ◽  
Author(s):  
Haydée Y. López ◽  
Dora A. Cortés-Hernández ◽  
Sergio Escobedo ◽  
D. Mantovani
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biomedical Applications ◽  
Degradation Rate ◽  
Magnesium Concentration ◽  
In Vitro Bioactivity ◽  
Ph Values ◽  
Heat Treated ◽  
Bonelike Apatite

In the aim to decrease the degradation rate of magnesium in simulated body fluid, pure magnesium was treated by two different routes, i) by soaking specimens in an HF aqueous solution at 30oC for 30 min and ii) by heating specimens at 345oC for 15 min. The treated samples were immersed in simulated body fluid (SBF) at 37oC for different periods of time. Samples with no treatment were also immersed in SBF. The magnesium released into the SBF, the weight loss of the specimens and the pH of SBF increased with time of immersion in all the cases. The heat treated samples showed a lower degradation rate and lower pH values. A substantial decrease of magnesium concentration in the SBF corresponding to the heat treated samples was also observed. However, the degradation rate of the heat treated samples remains being extremely high. On the other hand, a bonelike apatite layer was observed after only 3 days of immersion in SBF in all the cases. The thickness of this layer increased with time of immersion. Further research needs to be performed to decrease the degradation rate. However, these results indicate that magnesium is a highly potential bioactive material for biomedical applications.

scholarly journals Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 812
Author(s):  
Xiao-Yan Cao ◽  
Na Tian ◽  
Xiang Dong ◽  
Cheng-Kung Cheng
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Glass Fibers ◽  
Atomic Ratio ◽  
Apatite Formation ◽  
Degradation Behavior ◽  
Continuous Glass ◽  
Load Bearing ◽  
Sodium Magnesium

The emergence of polylactide composites reinforced with bioresorbable silicate glass fibers has allowed for the long-term success of biodegradable polymers in load-bearing orthopedic applications. However, few studies have reported on the degradation behavior and bioactivity of such biocomposites. The aim of this work was to investigate the degradation behavior and in vitro bioactivity of a novel biocomposite pin composed of bioresorbable continuous glass fibers and poly-L-D-lactide in simulated body fluid for 78 weeks. As the materials degraded, periodic spiral delamination formed microtubes and funnel-shaped structures in the biocomposite pins. It was speculated that the direction of degradation, from both ends towards the middle of the fibers and from the surface through to the bulk of the polymer matrix, could facilitate bone healing. Following immersion in simulated body fluid, a bone-like apatite layer formed on the biocomposite pins which had a similar composition and structure to natural bone. The sheet- and needle-like apatite nanostructure was doped with sodium, magnesium, and carbonate ions, which acted to lower the Ca/P atomic ratio to less than the stoichiometric apatite and presented a calcium-deficient apatite with low crystallinity. These findings demonstrated the bioactivity of the new biocomposite pins in vitro and their excellent potential for load-bearing applications.

The three-stage in vitro degradation behavior of mesoporous silica in simulated body fluid

2010 ◽  
Vol 131 (1-3) ◽  
pp. 314-320 ◽  
Author(s):  
Qianjun He ◽  
Jianlin Shi ◽  
Min Zhu ◽  
Yu Chen ◽  
Feng Chen
Keyword(s):  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Body Fluid ◽  
Degradation Behavior ◽  
In Vitro Degradation

IN-VITRO BEHAVIOUR OF BIPHASIC CALCIUM PHOSPHATE WITH DIFFERENT RATIO OF SILICA CONTENT IN SIMULATED BODY FLUID

2015 ◽  
Vol 23 (1) ◽  
pp. 1-14
Author(s):  
Sudirman Sahid ◽  
◽  
Nor Shahida Kader Bashah ◽  
Salina Sabudin ◽  
◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biphasic Calcium Phosphate ◽  
Silica Content

scholarly journals Tetracalcium Phosphate/Monetite/Calcium Sulfate Hemihdrate Biocement Powder Mixtures Prepared by the One-Step Synthesis for Preparation of Nanocrystalline Hydroxyapatite Biocement-Properties and In Vitro Evaluation

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2137
Author(s):  
Lubomir Medvecky ◽  
Maria Giretova ◽  
Radoslava Stulajterova ◽  
Lenka Luptakova ◽  
Tibor Sopcak
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Calcium Sulfate ◽  
Powder Mixtures ◽  
Liquid Component ◽  
Tetracalcium Phosphate ◽  
Nanocrystalline Hydroxyapatite ◽  
One Step ◽  
Calcium Sulfate Hemihydrate

A modified one-step process was used to prepare tetracalcium phosphate/monetite/calcium sulfate hemihydrate powder cement mixtures (CAS). The procedure allowed the formation of monetite and calcium sulfate hemihydrate (CSH) in the form of nanoparticles. It was hypothesized that the presence of nanoCSH in small amounts enhances the in vitro bioactivity of CAS cement in relation to osteogenic gene markers in mesenchymal stem cells (MSCs). The CAS powder mixtures with 15 and 5 wt.% CSH were prepared by milling powder tetracalcium phosphate in an ethanolic solution of both orthophosphoric and sulfuric acids. The CAS cements had short setting times (around 5 min). The fast setting of the cement samples after the addition of the liquid component (water solution of NaH2PO4) was due to the partial formation of calcium sulfate dihydrate and hydroxyapatite before soaking in SBF with a small change in the original phase composition in cement powder samples after milling. Nanocrystalline hydroxyapatite biocement was produced by soaking of cement samples after setting in simulated body fluid (SBF). The fast release of calcium ions from CAS5 cement, as well as a small rise in the pH of SBF during soaking, were demonstrated. After soaking in SBF for 7 days, the final product of the cement transformation was nanocrystalline hydroxyapatite. The compressive strength of the cement samples (up to 30 MPa) after soaking in simulated body fluid (SBF) was comparable to that of bone. Real time polymerase chain reaction (RT-PCR) analysis revealed statistically significant higher gene expressions of alkaline phosphatase (ALP), osteonectin (ON) and osteopontin (OP) in cells cultured for 14 days in CAS5 extract compared to CSH-free cement. The addition of a small amount of nanoCSH (5 wt.%) to the tetracalcium phosphate (TTCP)/monetite cement mixture significantly promoted the over expression of osteogenic markers in MSCs. The prepared CAS powder mixture with its enhanced bioactivity can be used for bone defect treatment and has good potential for bone healing.

scholarly journals Preparation and Degradation Characteristics of MAO/APS Composite Bio-Coating in Simulated Body Fluid

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 667
Author(s):  
Zexin Wang ◽  
Fei Ye ◽  
Liangyu Chen ◽  
Weigang Lv ◽  
Zhengyi Zhang ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Composite Coating ◽  
Body Fluid ◽  
Composite Coatings ◽  
Degradation Process ◽  
Ceramic Coatings ◽  
Immersion Test ◽  
Substrate Material ◽  
Atmospheric Plasma

In this work, ZK60 magnesium alloy was employed as a substrate material to produce ceramic coatings, containing Ca and P, by micro-arc oxidation (MAO). Atmospheric plasma spraying (APS) was used to prepare the hydroxyapatite layer (HA) on the MAO coating to obtain a composite coating for better biological activity. The coatings were examined by various means including an X-ray diffractometer, a scanning electron microscope and an energy spectrometer. Meanwhile, an electrochemical examination, immersion test and tensile test were used to evaluate the in vitro performance of the composite coatings. The results showed that the composite coating has a better corrosion resistance. In addition, this work proposed a degradation model of the composite coating in the simulated body fluid immersion test. This model explains the degradation process of the MAO/APS coating in SBF.

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