The ribosomal RNA transcription unit of Entamoeba invadens: Accumulation of unprocessed pre-rRNA and a long non coding RNA during encystation

2013 ◽  
Vol 192 (1-2) ◽  
pp. 30-38 ◽  
Author(s):  
Sandeep Ojha ◽  
Nishant Singh ◽  
Alok Bhattacharya ◽  
Sudha Bhattacharya
Keyword(s):  
Ribosomal Rna ◽  
Transcription Unit ◽  
Rna Transcription ◽  
Non Coding Rna ◽  
Entamoeba Invadens ◽  
Long Non Coding Rna

scholarly journals Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Dimitrios Papaioannou ◽  
Andreas Petri ◽  
Oliver M. Dovey ◽  
Sara Terreri ◽  
Eric Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Ribosomal Rna ◽  
Myeloid Leukemia ◽  
Rna Transcription ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Acute Myeloid

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Dimitrios Papaioannou ◽  
Andreas Petri ◽  
Oliver M. Dovey ◽  
Sara Terreri ◽  
Eric Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Ribosomal Rna ◽  
Myeloid Leukemia ◽  
Rna Transcription ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Acute Myeloid

scholarly journals Gene regulation by the act of long non-coding RNA transcription

BMC Biology ◽  
2013 ◽  
Vol 11 (1) ◽  
pp. 59 ◽  
Author(s):  
Aleksandra E Kornienko ◽  
Philipp M Guenzl ◽  
Denise P Barlow ◽  
Florian M Pauler
Keyword(s):  
Gene Regulation ◽  
Rna Transcription ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

Cell ◽  
2015 ◽  
Vol 161 (4) ◽  
pp. 774-789 ◽  
Author(s):  
Evangelos Pefanis ◽  
Jiguang Wang ◽  
Gerson Rothschild ◽  
Junghyun Lim ◽  
David Kazadi ◽  
...  
Keyword(s):  
Enhancer Activity ◽  
Rna Transcription ◽  
Super Enhancer ◽  
Non Coding Rna ◽  
Rna Exosome ◽  
Long Non Coding Rna

Radiological mapping of the ribosomal RNA transcription unit in E. coli

Nature ◽  
1974 ◽  
Vol 251 (5476) ◽  
pp. 639-641 ◽  
Author(s):  
PERRY B. HACKETT ◽  
WALTER SAUERBIER
Keyword(s):  
Ribosomal Rna ◽  
Transcription Unit ◽  
Rna Transcription ◽  
E Coli

scholarly journals The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Dimitrios Papaioannou ◽  
Andreas Petri ◽  
Oliver M. Dovey ◽  
Sara Terreri ◽  
Eric Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Ribosomal Rna ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Compensatory Mechanism ◽  
Rna Transcription ◽  
Non Coding Rna ◽  
Acute Myeloid

AbstractLong non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.

scholarly journals Functional impacts of non-coding RNA processing on enhancer activity and target gene expression

2019 ◽  
Vol 11 (10) ◽  
pp. 868-879 ◽  
Author(s):  
Evgenia Ntini ◽  
Annalisa Marsico
Keyword(s):  
Gene Expression ◽  
Rna Processing ◽  
Regulation Of Gene Expression ◽  
Regulatory Elements ◽  
Transcription Unit ◽  
Supporting Evidence ◽  
Enhancer Activity ◽  
Rna Transcripts ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Tight regulation of gene expression is orchestrated by enhancers. Through recent research advancements, it is becoming clear that enhancers are not solely distal regulatory elements harboring transcription factor binding sites and decorated with specific histone marks, but they rather display signatures of active transcription, showing distinct degrees of transcription unit organization. Thereby, a substantial fraction of enhancers give rise to different species of non-coding RNA transcripts with an unprecedented range of potential functions. In this review, we bring together data from recent studies indicating that non-coding RNA transcription from active enhancers, as well as enhancer-produced long non-coding RNA transcripts, may modulate or define the functional regulatory potential of the cognate enhancer. In addition, we summarize supporting evidence that RNA processing of the enhancer-associated long non-coding RNA transcripts may constitute an additional layer of regulation of enhancer activity, which contributes to the control and final outcome of enhancer-targeted gene expression.

Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
MP Ashton ◽  
I Tan ◽  
L Mackin ◽  
C Elso ◽  
E Chu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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