Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma

2004 ◽  
Vol 124 (2) ◽  
pp. 188-198 ◽  
Author(s):  
R. Ravikumar ◽  
Govinder Flora ◽  
James W. Geddes ◽  
Bernhard Hennig ◽  
Michal Toborek
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Transcription Factors ◽  
Spinal Cord Trauma ◽  
Stress Activation

scholarly journals NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats

Spinal Cord ◽  
2009 ◽  
Vol 48 (4) ◽  
pp. 285-289 ◽  
Author(s):  
M Vural ◽  
A Arslantaş ◽  
N Yazihan ◽  
T Köken ◽  
K Uzuner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Nmda Receptor ◽  
Spinal Cord Trauma

Erythropoietin improves oxidative stress following spinal cord trauma in rats

Injury ◽  
2008 ◽  
Vol 39 (12) ◽  
pp. 1408-1413 ◽  
Author(s):  
Nuray Yazihan ◽  
Kubilay Uzuner ◽  
Bulent Salman ◽  
Murat Vural ◽  
Tulay Koken ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Trauma

THE INDWELLING URETHRAL CATHETER IN PATIENTS WITH ACUTE SPINAL CORD TRAUMA

1973 ◽  
Vol 2 (2) ◽  
pp. 62-66 ◽  
Author(s):  
J. E. MAROSSZEKY ◽  
R. H. FARNSWORTH ◽  
R. F. JONES
Keyword(s):  
Spinal Cord ◽  
Urethral Catheter ◽  
Spinal Cord Trauma

scholarly journals NRF2-mediated signaling is a master regulator of transcription factors in bovine granulosa cells under oxidative stress condition

2021 ◽  
Author(s):  
Mohamed Omar Taqi ◽  
Mohammed Saeed-Zidane ◽  
Samuel Gebremedhn ◽  
Dessie Salilew-Wondim ◽  
Ernst Tholen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Endoplasmic Reticulum ◽  
Transcription Factors ◽  
Endoplasmic Reticulum Stress ◽  
Granulosa Cells ◽  
Mitochondrial Activity ◽  
Small Interference Rna ◽  
Nrf2 Signaling Pathway

AbstractTranscription factors (TFs) are known to be involved in regulating the expression of several classes of genes during folliculogenesis. However, the regulatory role of TFs during oxidative stress (OS) is not fully understood. The current study was aimed to investigate the regulation of the TFs in bovine granulosa cells (bGCs) during exposure to OS induced by H2O2 in vitro. For this, bGCs derived from ovarian follicles were cultured in vitro till their confluency and then treated with H2O2 for 40 min. Twenty-four hours later, cells were subjected to various phenotypic and gene expression analyses for genes related to TFs, endoplasmic reticulum stress, apoptosis, cell proliferation, and differentiation markers. The bGCs exhibited higher reactive oxygen species accumulation, DNA fragmentation, and endoplasmic reticulum stress accompanied by reduction of mitochondrial activity after exposure to OS. In addition, higher lipid accumulation and lower cell proliferation were noticed in H2O2-challenged cells. The mRNA level of TFs including NRF2, E2F1, KLF6, KLF9, FOS, SREBF1, SREBF2, and NOTCH1 was increased in H2O2-treated cells compared with non-treated controls. However, the expression level of KLF4 and its downstream gene, CCNB1, were downregulated in the H2O2-challenged group. Moreover, targeted inhibition of NRF2 using small interference RNA resulted in reduced expression of KLF9, FOS, SREBF2, and NOTCH1 genes, while the expression of KLF4 was upregulated. Taken together, bovine granulosa cells exposed to OS exhibited differential expression of various transcription factors, which are mediated by the NRF2 signaling pathway.

Sign in / Sign up

Export Citation Format

Share Document