Methamphetamine modulation of gene expression in the brain: Analysis using customized cDNA microarray system with the mouse homologues of KIAA genes

2005 ◽  
Vol 137 (1-2) ◽  
pp. 40-46 ◽  
Author(s):  
Hideko Yamamoto ◽  
Kazuhide Imai ◽  
Yukio Takamatsu ◽  
Etsuko Kamegaya ◽  
Makiko Kishida ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cdna Microarray ◽  
Modulation Of Gene Expression ◽  
The Brain

Cholera toxin-induced modulation of gene expression: elucidation via cDNA microarray for rational cell-based sensor design

2002 ◽  
Vol 457 (1) ◽  
pp. 97-108 ◽  
Author(s):  
Hsingchi J. Lin ◽  
P.T. Charles ◽  
Joanne D. Andreadis ◽  
A.M. Churilla ◽  
David A. Stenger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cholera Toxin ◽  
Cdna Microarray ◽  
Sensor Design ◽  
Modulation Of Gene Expression

scholarly journals Environmental stimuli shape microglial plasticity in glioma

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Stefano Garofalo ◽  
Alessandra Porzia ◽  
Fabrizio Mainiero ◽  
Silvia Di Angelantonio ◽  
Barbara Cortese ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nk Cells ◽  
Myeloid Cells ◽  
Environmental Cues ◽  
Inflammatory Gene Expression ◽  
Cytokines And Chemokines ◽  
Interleukin 15 ◽  
Modulation Of Gene Expression ◽  
Ifn Γ ◽  
The Brain

In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, which contribute to tumor growth and to maintaining a pro-tumorigenic, immunosuppressed microenvironment. We demonstrate that housing glioma-bearing mice in enriched environment (EE) reverts the immunosuppressive phenotype of infiltrating myeloid cells, by modulating inflammatory gene expression. Under these conditions, the branching and patrolling activity of myeloid cells is increased, and their phagocytic activity is promoted. Modulation of gene expression depends on interferon-(IFN)-γ produced by natural killer (NK) cells. This modulation disappears in mice depleted of NK cells or lacking IFN-γ, and was mimicked by exogenous interleukin-15 (IL-15). Further, we describe a key role for brain-derived neurotrophic factor (BDNF) that is produced in the brain of mice housed in EE, in mediating the expression of IL-15 in CD11b+ cells. These data define novel mechanisms linking environmental cues to the acquisition of a pro-inflammatory, anti-tumor microenvironment in mouse brain.

1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1805-P
Author(s):  
WEIKANG CAI ◽  
THIAGO M. BATISTA ◽  
RUBEN GARCIA MARTIN ◽  
ALFRED RAMIREZ ◽  
MASAHIRO KONISHI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Metabolism ◽  
The Brain
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