Regulatory T cells express Tumor Necrosis Factor Receptor 2 with the highest intensity among CD4+ T cells in the draining lymph nodes of breast cancer

2021 ◽  
Vol 137 ◽  
pp. 52-56
Author(s):  
Atri Ghods ◽  
Fereshteh Mehdipour ◽  
Mahmoud Shariat ◽  
Abdol-Rasoul Talei ◽  
Abbas Ghaderi
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Lymph Nodes ◽  
Cd4 T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Draining Lymph Nodes ◽  
Necrosis Factor

Tumor Necrosis Factor Receptor Expression in HIV-1-Infected CD4+ T Cells

1994 ◽  
Vol 38 (12) ◽  
pp. 1005-1008 ◽  
Author(s):  
Didier Hober ◽  
Donat de Groote ◽  
Nathalie Vanpouille ◽  
Isabelle Dehart ◽  
Lu Shen ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Cd4 T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Receptor Expression ◽  
Hiv 1 ◽  
Necrosis Factor

Regulatory T Cells Expressing Tumor Necrosis Factor Receptor Type 2 Play a Major Role in CD4+ T-Cell Impairment During Sepsis

2020 ◽  
Vol 222 (7) ◽  
pp. 1222-1234 ◽  
Author(s):  
Benjamin J Gaborit ◽  
Antoine Roquilly ◽  
Cédric Louvet ◽  
Abderrahmane Sadek ◽  
Benoit Tessoulin ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Cd4 T Cell ◽  
Treg Subset ◽  
Necrosis Factor

Abstract Sepsis causes inflammation-induced immunosuppression with lymphopenia and alterations of CD4+ T-cell functions that renders the host prone to secondary infections. Whether and how regulatory T cells (Treg) are involved in this postseptic immunosuppression is unknown. We observed in vivo that early activation of Treg during Staphylococcus aureus sepsis induces CD4+ T-cell impairment and increases susceptibility to secondary pneumonia. The tumor necrosis factor receptor 2 positive (TNFR2pos) Treg subset endorsed the majority of effector immunosuppressive functions, and TNRF2 was particularly associated with activation of genes involved in cell cycle and replication in Treg, probably explaining their maintenance. Blocking or deleting TNFR2 during sepsis decreased the susceptibility to secondary infection. In humans, our data paralleled those in mice; the expression of CTLA-4 was dramatically increased in TNFR2pos Treg after culture in vitro with S. aureus. Our findings describe in vivo mechanisms underlying sepsis-induced immunosuppression and identify TNFR2pos Treg as targets for therapeutic intervention.

scholarly journals Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

2014 ◽  
Vol 15 (5) ◽  
pp. 473-481 ◽  
Author(s):  
Shawn A Mahmud ◽  
Luke S Manlove ◽  
Heather M Schmitz ◽  
Yan Xing ◽  
Yanyan Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Signal Strength ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

2013 ◽  
Vol 34 (6) ◽  
pp. 1296-1303 ◽  
Author(s):  
Martin Chopra ◽  
Simone S. Riedel ◽  
Marlene Biehl ◽  
Stefanie Krieger ◽  
Viktoria von Krosigk ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Experimental Metastasis ◽  
Necrosis Factor

Pretransplant Recipient Circulating CD4+CD127lo/− Tumor Necrosis Factor Receptor 2+ Regulatory T Cells

2016 ◽  
Vol 100 (2) ◽  
pp. 314-324 ◽  
Author(s):  
Minh-Tri J. P. Nguyen ◽  
Elise Fryml ◽  
Sossy K. Sahakian ◽  
Shuqing Liu ◽  
Marcelo Cantarovich ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Necrosis Factor
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