Insights into the structural changes of bovine serum albumin in ethanolammonium laurate based surface active ionic liquids

2019 ◽  
Vol 290 ◽  
pp. 111229 ◽  
Author(s):  
Anu Aravind Thoppil ◽  
Bharath Kumar Chennuri ◽  
Ramesh L. Gardas
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Structural Changes ◽  
Surface Active

Insights into the interaction of Bovine Serum Albumin with Surface-Active Ionic Liquids in aqueous solution

2020 ◽  
pp. 114537
Author(s):  
Márcia M.S. Alves ◽  
João M.M. Araújo ◽  
Ivo C. Martins ◽  
Ana B. Pereiro ◽  
Margarida Archer
Keyword(s):  
Aqueous Solution ◽  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Surface Active

scholarly journals Aqueous colloidal systems of bovine serum albumin and functionalized surface active ionic liquids for material transport

RSC Advances ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 7073-7082
Author(s):  
Gagandeep Singh ◽  
Manvir Kaur ◽  
Vinod Kumar Aswal ◽  
Tejwant Singh Kang
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Colloidal Systems ◽  
Computational Investigation ◽  
Material Transport ◽  
Surface Active ◽  
Functionalized Surface

Physicochemical and computational investigation of complexation between BSA and SAILs with application in material transport.

Ionic Liquids Induced Structural Changes of Bovine Serum Albumin in Aqueous Media: A Detailed Physicochemical and Spectroscopic Study

2012 ◽  
Vol 116 (39) ◽  
pp. 11924-11935 ◽  
Author(s):  
Tejwant Singh ◽  
Pankaj Bharmoria ◽  
Masa-aki Morikawa ◽  
Nobuo Kimizuka ◽  
Arvind Kumar
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Spectroscopic Study ◽  
Bovine Serum ◽  
Structural Changes ◽  
Aqueous Media

Influence of metal ions on thermal aggregation of bovine serum albumin: Aggregation kinetics and structural changes

2009 ◽  
Vol 103 (12) ◽  
pp. 1729-1738 ◽  
Author(s):  
Giovanna Navarra ◽  
Anna Tinti ◽  
Maurizio Leone ◽  
Valeria Militello ◽  
Armida Torreggiani
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Ions ◽  
Bovine Serum ◽  
Structural Changes ◽  
Aggregation Kinetics ◽  
Thermal Aggregation

A spectroscopic and molecular dynamics simulation approach towards the stabilizing effect of ammonium-based ionic liquids on bovine serum albumin

2017 ◽  
Vol 41 (19) ◽  
pp. 10712-10722 ◽  
Author(s):  
Lakkoji Satish ◽  
Sabera Millan ◽  
Krishnendu Bera ◽  
Sujata Mohapatra ◽  
Harekrushna Sahoo
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Dynamics Simulation ◽  
Thermal Unfolding ◽  
Simulation Approach ◽  
Stabilizing Effect ◽  
Theoretical Evidence

Experimental and theoretical evidence in support of the stabilizing effect of ammonium-based ionic liquids on thermal unfolding/refolding of bovine serum albumin is provided in this article.

scholarly journals Ketoprofen-Based Ionic Liquids: Synthesis and Interactions with Bovine Serum Albumin

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 90 ◽  
Author(s):  
Paula Ossowicz ◽  
Proletina Kardaleva ◽  
Maya Guncheva ◽  
Joanna Klebeko ◽  
Ewelina Świątek ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Binding Constants ◽  
Protein Molecule ◽  
Binding Mode ◽  
Pharmaceutical Ingredients ◽  
System A ◽  
Static Mechanism

The development of ionic liquids based on active pharmaceutical ingredients (API-ILs) is a possible solution to some of the problems of solid and/or hydrophobic drugs such as low solubility and bioavailability, polymorphism and an alternative route of administration could be suggested as compared to the classical drug. Here, we report for the first time the synthesis and detailed characterization of a series of ILs containing a cation amino acid esters and anion ketoprofen (KETO-ILs). The affinity and the binding mode of the KETO-ILs to bovine serum albumin (BSA) were assessed using fluorescence spectroscopy. All compounds bind in a distance not longer than 6.14 nm to the BSA fluorophores. The estimated binding constants (KA) are in order of 105 L mol−1, which is indicative of strong drug or IL-BSA interactions. With respect to the ketoprofen-BSA system, a stronger affinity of the ILs containing l-LeuOEt, l-ValOBu, and l-ValOEt cation towards BSA is clearly seen. Fourier transformed infrared spectroscopy experiments have shown that all studied compounds induced a rearrangement of the protein molecule upon binding, which is consistent with the suggested static mechanism of BSA fluorescence quenching and formation of complexes between BSA and the drugs. All tested compounds were safe for macrophages.

Interaction mechanisms of ionic liquids [Cnmim]Br (n=4, 6, 8, 10) with bovine serum albumin

2012 ◽  
Vol 132 (3) ◽  
pp. 622-628 ◽  
Author(s):  
Hua Yan ◽  
Junyong Wu ◽  
Guoliang Dai ◽  
Aiguo Zhong ◽  
Hao Chen ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Interaction Mechanisms
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