Design and synthesis of new flavonols as dual ɑ-amylase and ɑ-glucosidase inhibitors: Structure-activity relationship, drug-likeness, in vitro and in silico studies

2020 ◽  
Vol 1218 ◽  
pp. 128458 ◽  
Author(s):  
Jamshaid Ashraf ◽  
Ehsan Ullah Mughal ◽  
Amina Sadiq ◽  
Nafeesa Naeem ◽  
Syed Aun Muhammad ◽  
...  
Keyword(s):  
In Silico ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Glucosidase Inhibitors ◽  
In Silico Studies

Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents

2021 ◽  
Vol 6 (31) ◽  
pp. 7860-7872
Author(s):  
Ismail M. M. Othman ◽  
Mohamed A. M. Gad‐Elkareem ◽  
Hyam A. Radwan ◽  
Riadh Badraoui ◽  
Kaïss Aouadi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
In Silico ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
In Silico Studies

Structure–activity relationship study of dendritic polyglycerolamines for efficient siRNA transfection

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 78760-78770 ◽  
Author(s):  
Fatemeh Sheikhi Mehrabadi ◽  
Ole Hirsch ◽  
Reiner Zeisig ◽  
Paola Posocco ◽  
Erik Laurini ◽  
...  
Keyword(s):  
In Silico ◽  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Sirna Transfection ◽  
Structure Activity ◽  
Relationship Study

Structure–activity relationship studies were performed through in vitro, in silico, and in vivo analysis in order to evaluate the gene transfection potential of dendritic polyglycerolamines with different amine loadings.

Structure-Activity Relationship Study of 16 a-Thiocamptothecins: an Integrated In Vitro and In Silico Approach

ChemMedChem ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. 2006-2015 ◽  
Author(s):  
Cristian Samorì ◽  
Giovanni L. Beretta ◽  
Greta Varchi ◽  
Andrea Guerrini ◽  
Simone DiemspMicco ◽  
...  
Keyword(s):  
In Silico ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study
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