Correction to “Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure–Activity Relationship, and In Silico Studies”

ACS Omega ◽  
2021 ◽  
Author(s):  
Kanwal ◽  
Khalid Mohammed Khan ◽  
Sridevi Chigurupati ◽  
Farman Ali ◽  
Munisaa Younus ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
In Silico ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Activity Structure ◽  
Antioxidant Agents ◽  
In Silico Studies

One-pot green synthesis of acridine alkaloid derivatives and screening of in vitro anticancer activity against Cdc25b and SHP1

2020 ◽  
Vol 17 ◽  
Author(s):  
Hao Li ◽  
Buer Song ◽  
Mamtimin Mahmut ◽  
Mukhtar Imerhasan
Keyword(s):  
Green Synthesis ◽  
Anticancer Activity ◽  
Inhibitory Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
One Pot ◽  
Structure Activity ◽  
Dna 2 ◽  
Acridone Derivatives

Aims: To develop of anticancer active pharmaceutical intermediates. Background: Acridone derivatives possesses wide range of pharmacological activities:1) intercalate DNA 2) form covalent bond with DNA. Objective: To Screening of in vitro anticancer activity against Cdc25b and SHP1 of new acridone derivatives and preliminary study on structure-activity relationship. Materials and Methods: Synthesis of new acridone derivatives and in vitro evaluation of their anticancer activity on Cdc25b and SHP1. Natural products that contain acridine structures, such as cystodytin A and acronycine, are isolated from certain marine (tunicates & ascidians, sponges, sea anemones) and plant (bark of Australian scrub ash tree) species. Herein, we report the efficient one-pot green synthesis of twelve novel 3,4-dihydro-1 (2H) acridone derivatives, using montmorillonite K10 as the catalyst and iron/citric acid in water. Also, their inhibitory activity against Cdc25B and SHP1 is examined, in which specific derivatives show enhanced inhibitory activity compared to others. Results and Discussion: Starting from 2-nitrobenzaldehyde derivatives and 1, 3-cyclohexanedione derivatives, twelve new acridone derivatives were prepared and exhibited substantial anticancer activity against Cdc25b and SHP1 cells. Conclusion: Preliminary studies of the structure-activity relationship have shown the influence of the structural parameters and, in particular, the nature of the substituent on aromatic ring structure and cyclohexanone. Other: Further study on structure-activity relationship.

Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents

2021 ◽  
Vol 6 (31) ◽  
pp. 7860-7872
Author(s):  
Ismail M. M. Othman ◽  
Mohamed A. M. Gad‐Elkareem ◽  
Hyam A. Radwan ◽  
Riadh Badraoui ◽  
Kaïss Aouadi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
In Silico ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
In Silico Studies

Structure–activity relationship study of dendritic polyglycerolamines for efficient siRNA transfection

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 78760-78770 ◽  
Author(s):  
Fatemeh Sheikhi Mehrabadi ◽  
Ole Hirsch ◽  
Reiner Zeisig ◽  
Paola Posocco ◽  
Erik Laurini ◽  
...  
Keyword(s):  
In Silico ◽  
Gene Transfection ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Sirna Transfection ◽  
Structure Activity ◽  
Relationship Study

Structure–activity relationship studies were performed through in vitro, in silico, and in vivo analysis in order to evaluate the gene transfection potential of dendritic polyglycerolamines with different amine loadings.

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