Preparation of porous carboxymethyl chitosan grafted poly (acrylic acid) superabsorbent by solvent precipitation and its application as a hemostatic wound dressing

2016 ◽  
Vol 63 ◽  
pp. 18-29 ◽  
Author(s):  
Yu Chen ◽  
Yong Zhang ◽  
Fengju Wang ◽  
Weiwei Meng ◽  
Xinlin Yang ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Wound Dressing ◽  
Carboxymethyl Chitosan ◽  
Poly Acrylic Acid

scholarly journals Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for Chronic Wounds

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1323 ◽  
Author(s):  
Clarence Chuah ◽  
Jing Wang ◽  
Javad Tavakoli ◽  
Youhong Tang
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Bacterial Cellulose ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Hybrid Composites ◽  
Morphological Characteristics ◽  
Infrared Analysis ◽  
Slight Reduction ◽  
Poly Acrylic Acid

This investigation examines the combination of poly (acrylic acid) (PAA) and bacterial cellulose (BC) nanofibers to synthesize hydrogel hybrid composites used for wound dressing application. Amoxicillin (AM) was also grafted onto the composites for drug release. Fourier transform infrared analysis and scanning electron microscopy conducted revealed the structure and porosity of the composite being developed, as well as the successful fabrication of BC-PAA composites. The results of mechanical testing and hygroscopicity revealed that the composite shows higher stability than hydrogels which are currently used worldwide, albeit with a slight reduction in swelling capabilities. However, the composite was revealed to be responsive to a rise in pH values with an increase in composite swelling and drug release. These results together with their morphological characteristics suggest that BC-PAA hydrogel hybrid composite is a promising candidate for wound dressing application.

Novel polymeric composites based on carboxymethyl chitosan and poly(acrylic acid): in vitro and in vivo evaluation

2017 ◽  
Vol 28 (10) ◽  
Author(s):  
Qurat-ul-Ain Sharif ◽  
Muhammad Sohail ◽  
Mahmood Ahmad ◽  
Muhammad Usman Minhas ◽  
Shahzeb Khan ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Polymeric Composites ◽  
Carboxymethyl Chitosan ◽  
In Vivo Evaluation ◽  
Poly Acrylic Acid

scholarly journals Investigation of Regenerated Cellulose/Poly(acrylic acid) Composite Films for Potential Wound Healing Applications: A Preliminary Study

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Manjula Bajpai ◽  
S. K. Bajpai ◽  
Dinesh Gautam
Keyword(s):  
Acrylic Acid ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Composite Films ◽  
Regenerated Cellulose ◽  
Antibacterial Drug ◽  
Antifungal Action ◽  
Release Data ◽  
Antibacterial And Antifungal ◽  
Poly Acrylic Acid

Regenerated cellulose/poly(acrylic acid) composite films have been synthesized for wound dressing applications. The water absorbency of these films was studied as a function of amount of cross-linker N,N′-methylenebisacrylamide and cellulose contents in the feed mixture. The samples, having different compositions, showed tensile strength and percent elongation in the range of 9.98×105 to 13.40×105 N/m2 and 110 to 265, respectively. The water vapor transmission rate (WVTR) for various films was found to be in the range of 2.03 to 7.18 mg/cm2/h. These films were loaded with antibacterial drug miconazole nitrate and their release was studied in the physiological pH at 37°C. The release data was found to fit well the diffusion controlled Higuchi model. Finally the films demonstrated fair antibacterial and antifungal action, thus establishing their strong candidature as wound dressing materials.

Fabrication of Sustained Release System of Electrospun Poly(acrylic acid)/Dextran Nanofibers Using Emulsion Electrospinning as Wound Dressing Applications

2021 ◽  
Vol 21 (3) ◽  
pp. 1613-1622
Author(s):  
A. Meera Moydeen ◽  
Badr M. Thamer ◽  
Ali Aldalbahi ◽  
Hany El-Hamshary ◽  
Abdullah M. Al-Enizi ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Acrylic Acid ◽  
Sustained Release ◽  
Wound Dressing ◽  
Confocal Laser ◽  
Release Mechanism ◽  
Core Shell ◽  
Burst Release ◽  
Release Behavior ◽  
Poly Acrylic Acid

The burst release of drug is a problem associated with the use of common blending electrospinning. This problem can be avoided via fabrication of core–shell nanofibers where drug can be coated with polymer nanofibers as a shell. Moreover, there is a need to provide wound dressing with prolonged system of sustained release to accelerate the recovery of the wound. Currently, electrospun ciprofloxacin loaded poly(acrylic acid)/Dextran (Cipro@PAA/Dex) core–shell nanofibers can be prepared in green method using emulsion electrospinning. For comparison study, blend electrospun nanofibers (Cipro/PAA/Dex) was also prepared. The entrapment of drug into the polymeric material and the interaction between polymer blends were confirmed by FT-IR. Moreover, DSC was used to identify the type of interaction between polymeric chains. Field emission scanning electron microscope (FE-SEM) was used to study the nanofiber morphology and transmission electron microscope (TEM) and confocal laser scanning microscope (CLSM) were used to confirm the formation of core–shell structure. In vitro drug release profile was monitored by UV-Vis spectrophotometer and the results showed that Cipro@PAA/Dex exhibited controlled release behavior whereas Cipro/PAA/Dex showed burst release behavior. Moreover, the release mechanism is kinetically followed diffusion.

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