A new bi-layered scaffold for osteochondral tissue regeneration: In vitro and in vivo preclinical investigations

2017 ◽  
Vol 70 ◽  
pp. 101-111 ◽  
Author(s):  
M. Sartori ◽  
S. Pagani ◽  
A. Ferrari ◽  
V. Costa ◽  
V. Carina ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Regeneration In Vitro ◽  
Osteochondral Tissue

Effects of the tetrahedral framework nucleic acids on the skeletal muscle regeneration in vitro and in vivo

2020 ◽  
Vol 4 (9) ◽  
pp. 2731-2743
Author(s):  
Yang Gao ◽  
Tianxu Zhang ◽  
Junyao Zhu ◽  
Dexuan Xiao ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Muscle Loss ◽  
Degenerative Diseases ◽  
Tetrahedral Framework ◽  
Volumetric Muscle Loss ◽  
Regeneration In Vitro

The challenges associated with muscle degenerative diseases and volumetric muscle loss (VML) emphasizes the prospects of muscle tissue regeneration.

Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo

2017 ◽  
Vol 104 ◽  
pp. 1975-1985 ◽  
Author(s):  
S. Saravanan ◽  
Anjali Chawla ◽  
M. Vairamani ◽  
T.P. Sastry ◽  
K.S. Subramanian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Regeneration In Vitro

scholarly journals Bioactive Sr(II)/Chitosan/Poly(ε-caprolactone) Scaffolds for Craniofacial Tissue Regeneration. In Vitro and In Vivo Behavior

Polymers ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 279 ◽  
Author(s):  
Itzia Rodríguez-Méndez ◽  
Mar Fernández-Gutiérrez ◽  
Amairany Rodríguez-Navarrete ◽  
Raúl Rosales-Ibáñez ◽  
Lorena Benito-Garzón ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Regeneration In Vitro ◽  
Craniofacial Tissue

Nonmulberry silk protein sericin blend hydrogels for skin tissue regeneration - in vitro and in vivo

2019 ◽  
Vol 137 ◽  
pp. 545-553 ◽  
Author(s):  
Sunaina Sapru ◽  
Subhayan Das ◽  
Mahitosh Mandal ◽  
Ananta K. Ghosh ◽  
Subhas C. Kundu
Keyword(s):  
Tissue Regeneration ◽  
Silk Protein ◽  
Skin Tissue ◽  
Regeneration In Vitro

Novel cellulose/hydroxyapatite scaffolds for bone tissue regeneration: In vitro and in vivo study

2018 ◽  
Vol 12 (5) ◽  
pp. 1195-1208 ◽  
Author(s):  
Povilas Daugela ◽  
Mindaugas Pranskunas ◽  
Gintaras Juodzbalys ◽  
Jolanta Liesiene ◽  
Odeta Baniukaitiene ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
In Vivo Study ◽  
Regeneration In Vitro

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

scholarly journals The Radiation-Induced Regenerative Response of Adult Tissue-Specific Stem Cells: Models and Signaling Pathways

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 855
Author(s):  
Paola Serrano Martinez ◽  
Lorena Giuranno ◽  
Marc Vooijs ◽  
Robert P. Coppes
Keyword(s):  
Signaling Pathways ◽  
Progenitor Cells ◽  
Tissue Regeneration ◽  
Normal Tissue ◽  
Cellular Response ◽  
Adult Tissue ◽  
Tissue Specific ◽  
Radiation Induced

Radiotherapy is involved in the treatment of many cancers, but damage induced to the surrounding normal tissue is often inevitable. Evidence suggests that the maintenance of homeostasis and regeneration of the normal tissue is driven by specific adult tissue stem/progenitor cells. These tasks involve the input from several signaling pathways. Irradiation also targets these stem/progenitor cells, triggering a cellular response aimed at achieving tissue regeneration. Here we discuss the currently used in vitro and in vivo models and the involved specific tissue stem/progenitor cell signaling pathways to study the response to irradiation. The combination of the use of complex in vitro models that offer high in vivo resemblance and lineage tracing models, which address organ complexity constitute potential tools for the study of the stem/progenitor cellular response post-irradiation. The Notch, Wnt, Hippo, Hedgehog, and autophagy signaling pathways have been found as crucial for driving stem/progenitor radiation-induced tissue regeneration. We review how these signaling pathways drive the response of solid tissue-specific stem/progenitor cells to radiotherapy and the used models to address this.

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