Peptide functionalized poly ethylene glycol-poly caprolactone nanomicelles for specific cabazitaxel delivery to metastatic breast cancer cells

2017 ◽  
Vol 80 ◽  
pp. 301-312 ◽  
Author(s):  
Parvin Mahdaviani ◽  
Saeed Bahadorikhalili ◽  
Mona Navaei-Nigjeh ◽  
Seyed Yaser Vafaei ◽  
Mehdi Esfandyari-Manesh ◽  
...  
2019 ◽  
Vol 43 (1) ◽  
pp. 238-248 ◽  
Author(s):  
Roya Binaymotlagh ◽  
Farid Hajareh Haghighi ◽  
Fatemeh Aboutalebi ◽  
Seyede Zohreh Mirahmadi-Zare ◽  
Hassan Hadadzadeh ◽  
...  

The combination of diagnosis and targeted therapy within a single nanoplatform is one of the remarkable advances in molecular medicine.


Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 169 ◽  
Author(s):  
Alicja Zajdel ◽  
Adam Wilczok ◽  
Katarzyna Jelonek ◽  
Monika Musiał-Kulik ◽  
Aleksander Foryś ◽  
...  

To find better strategies to enhance the cytotoxic effect of paclitaxel (PTX) and lapatinib (LAP) against breast cancer cells, we analyzed the efficacy of a novel delivery system containing polylactide-co-poly(ethylene glycol) (PLA-PEG) filomicelles of over 100 nm in length and spherical micelles of approximately 20 nm in diameter. The 1H NMR measurements confirmed the incorporation of PTX and LAP into micelles. Analysis of the drug release mechanism revealed the diffusion-controlled release of LAP and anomalous transport of PTX. Drug content analysis in lyophilized micelles and micellar solution showed their good storage stability for at least 6 weeks. Blank micelles, LAP-loaded micelles and free LAP did not affect MCF-7 breast cancer cell proliferation, suggesting that the cytotoxicity of PTX-, PTX/LAP-loaded micelles, and the binary mixture of free PTX and LAP was solely caused by PTX. PTX/LAP-loaded micelles showed greater toxicity compared to the binary mixture of PTX and LAP after 48 h and 72 h. Only free PTX alone induced P-gp activity. This study showed the feasibility of using a LAP and PTX combination to overcome MDR in MCF-7 cells, particularly when co-loaded into micelles. We suggest that PTX/LAP micelles can be applicable not only for the therapy of HER-2-positive, but also HER-2-negative breast cancers.


Nanoscale ◽  
2018 ◽  
Vol 10 (18) ◽  
pp. 8413-8421 ◽  
Author(s):  
B. Newland ◽  
C. Taplan ◽  
D. Pette ◽  
J. Friedrichs ◽  
M. Steinhart ◽  
...  

Soft/flexible PEG-based polymer nanotubes released doxorubicin over a sustained period and reduced tumor growth in a metastatic breast cancer model.


Heliyon ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. e06252
Author(s):  
Wei Chen ◽  
Shihyun Park ◽  
Chrishma Patel ◽  
Yuxin Bai ◽  
Karim Henary ◽  
...  

2020 ◽  
Vol 107 ◽  
pp. 65-77 ◽  
Author(s):  
Akshay A. Narkhede ◽  
James H. Crenshaw ◽  
David K. Crossman ◽  
Lalita A. Shevde ◽  
Shreyas S. Rao

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