Osteogenic enhancement of silk fibroin-based bone scaffolds by forming hybrid composites with bioactive glass through GPTMS during sol-gel process

The possibility of enhancing mechanical properties by incorporation of polymeric components to sol-gel derived materials is extremely attractive to prepare macroporous scaffolds, leading to materials with potential applications in both hard and soft tissue regeneration. In this work bioactive glass-polyvinyl alcohol hybrids were developed and their mechanical behavior was evaluated. Hybrids were synthesized by adding polyvinyl alcohol to a sol-gel precursor solution, which was then foamed with the addition of a surfactant and vigorous agitation. The foams were cast, aged and dried at 40°C. A cleaning step to decrease the acidic character of the obtained hybrids was undertaken by immersion in a NH4OH solution. The mechanical behavior of the hybrids was evaluated in compression using both stress and strain control tests. Hybrid foams had a high porosity varying from 60-90% and the macropore diameter ranged from 10 to 600 µm. The modal macropore diameter varied with the inorganic phase composition and with the polymer content in the hybrid. The strain at fracture of the as prepared hybrid foams was substantially greater than pure gel-glass foams. The cleaned hybrids presented a slightly higher strength and lower deformation than the as prepared foams.

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Evaluation of bioactive glass synthesized by alkali-mediated sol-gel process

Vietnam Journal of Chemistry ◽

10.1002/vjch.201960013 ◽

2019 ◽

Vol 57 (1) ◽

pp. 80-84

Author(s):

Bui Xuan Vuong

Keyword(s):

Bioactive Glass ◽

Sol Gel ◽

Sol Gel Process

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Preparation and Properties of Porous Apatite-Wollastonite Bioactive Glass-Ceramic

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.169 ◽

2007 ◽

Vol 330-332 ◽

pp. 169-172 ◽

Cited By ~ 4

Author(s):

Ming Xue ◽

Jun Ou ◽

Da Li Zhou ◽

Dange Feng ◽

Wei Zhong Yang ◽

...

Keyword(s):

Bioactive Glass ◽

Stromal Cells ◽

Glass Ceramic ◽

Sol Gel ◽

Three Dimensional ◽

Chemical Properties ◽

Polymer Foam ◽

Physical Chemical ◽

Sol Gel Process ◽

Precursor Powders

The porous apatite-wollastonite bioactive glass-ceramic (AW-GG) was made from nano-precursor powders derived from sol-gel process, and shaped by dipping method with polymer foam. The physical-chemical properties, bioactivity and biocompatibility of the materials were studied by means of TG, XRD, SEM, TEM and so on. The bioactivity was investigated in simulated body fluid (SBF) and the biocompatibility was evaluated by co-culturing with marrow stromal cells (MSCs). The result shows that: the particle size of the AW precursor powders is 40~100nm; porous AW GC has three-dimensional pored structure with 300~500um macropores and 2~5um micropores; the materials possess high bioactivity and biocompatibility. Porous AW GC may therefore have great potential application as bone tissue engineering scaffold.

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Mesoporous 45S5 bioactive glass: synthesis, in vitro dissolution and biomineralization behavior

Journal of Materials Chemistry B ◽

10.1039/c7tb01738c ◽

2017 ◽

Vol 5 (44) ◽

pp. 8786-8798 ◽

Cited By ~ 16

Author(s):

Anil Kumar ◽

Sevi Murugavel ◽

Anusha Aditya ◽

Aldo R. Boccaccini

Keyword(s):

Bioactive Glass ◽

Sol Gel ◽

Sodium Oxide ◽

In Vitro Dissolution ◽

Established Method ◽

Sol Gel Process ◽

New Generation

The development of a new generation of biomaterials includes a sol–gel process to obtain glass foams, which is a well established method for CaO–SiO2–P2O5 compositions, but is not yet recognized for Bioglass® containing sodium oxide.

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Synthesis and Electrospinning of ε-Polycaprolactone-Bioactive Glass Hybrid Biomaterials via a Sol−Gel Process

Langmuir ◽

10.1021/la102845k ◽

2010 ◽

Vol 26 (23) ◽

pp. 18340-18348 ◽

Cited By ~ 82

Author(s):

Bedilu A. Allo ◽

Amin S. Rizkalla ◽

Kibret Mequanint

Keyword(s):

Bioactive Glass ◽

Sol Gel ◽

Sol Gel Process ◽

Hybrid Biomaterials

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Effect of Increasing Polyvinyl Alcohol Content on the Porous Structure and Mechanical Properties of Sol-Gel Derived Hybrids Foams

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.361-363.555 ◽

2007 ◽

Vol 361-363 ◽

pp. 555-558 ◽

Cited By ~ 2

Author(s):

Agda Aline Rocha de Oliveira ◽

R.L. Oréfice ◽

Herman S. Mansur ◽

Marivalda Pereira

Keyword(s):

Mechanical Properties ◽

Polyvinyl Alcohol ◽

Bioactive Glass ◽

Structural Characteristics ◽

Sol Gel ◽

Acetate Solution ◽

Compression Tests ◽

Sol Gel Process ◽

Hybrid Foams

Bioactive glass/polymer hybrids are promising materials for biomedical applications because they combine the bioactivity of these bioceramics with the flexibility of polymers. In previous work hybrid foams with 80% bioactive glass and 20% polyvinyl alcohol (PVA) were prepared by the sol-gel process for application as scaffold for bone tissue engineering. In this work it was evaluated the effect of increasing the PVA content of the hybrids on structural characteristics and mechanical properties of hybrid foams produced by this method. The hybrids were prepared with inorganic phase composition of 70%SiO2-30%CaO and PVA fractions of 20 to 60% by the sol-gel method. The structural and mechanical characterization of the obtained foams was done by FTIR, SEM, Helium Picnometry, and compression tests. To reduce the acidic character of the hybrids due to the catalysts added, different neutralization solutions were tested. The immersion of hybrids in a calcium acetate solution was the most adequate neutralization method, avoiding calcium loss while maintaining pH nearly 7,0 and low PVA loss. The foams presented porosity of 60-85% and pore diameters of 100-500μm with interconnected structure. The pore structure varied with the polymer content in the hybrid. The compression tests showed that an increase of PVA fraction in the hybrids improved their mechanical properties.

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