scholarly journals Macromolecules with Different Charges, Lengths, and Coordination Groups for the Coprecipitation Synthesis of Magnetic Iron Oxide Nanoparticles as T1 MRI Contrast Agents

Nanomaterials ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 699 ◽  
Author(s):  
Cheng Tao ◽  
Yanan Chen ◽  
Danli Wang ◽  
Yu Cai ◽  
Qiang Zheng ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Mri Contrast Agents ◽  
Hydroxyl Groups ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Cell Viability Assay ◽  
Mri Contrast ◽  
T1 Contrast ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Magnetic Fe3o4

Considerable efforts have been focused on the exploitation of macromolecule ligands for synthesis of magnetic Fe3O4 nanoparticles as T1 magnetic resonance imaging (MRI) contrast agents, but studies that concern macromolecule ligands with different charges and coordination groups are still limited. Herein, we used poly(acrylic acid) (PAA), poly(allylamine hydrochloride) (PAH), and polyvinyl alcohol (PVA), which possess negative, positive and neutral charges with carboxylic acid, amino and hydroxyl groups respectively, as templates and stabilizers to fabricate Fe3O4 nanoparticles through coprecipitation reaction. The obtained Fe3O4-PAA, Fe3O4-PAH, and Fe3O4-PVA nanoparticles showed T1 contrast performance with r1 relaxivities of 23.4, 60.3, and 30.6 mM s−1 at 0.5 T (25 °C), and a r2/r1 ratio of 2.62, 3.82, and 7.26, respectively. The cell viability assay revealed that Fe3O4-PAA and Fe3O4-PVA exhibited good biocompatibility, while Fe3O4-PAH displayed high cytotoxicity. In vivo T1-weighted (1 T) mice showed that both Fe3O4-PAA and Fe3O4-PVA were able to display remarkably brighten the contrast enhancement for the mice tumor and kidney sites, but Fe3O4-PAA had better contrast performance. This work highlights that the macromolecule ligands play an important role in the biocompatibility and T1 contrast performance of magnetic Fe3O4 nanoparticles.

Magnetic Fe3O4 nanoparticles coated by natural rubber latex as MRI contrast agent

2019 ◽  
Vol 475 ◽  
pp. 458-464 ◽  
Author(s):  
Soudabeh Arsalani ◽  
Eder J. Guidelli ◽  
Matheus A. Silveira ◽  
Carlos E.G. Salmon ◽  
Jefferson F.D.F. Araujo ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Natural Rubber ◽  
Fe3o4 Nanoparticles ◽  
Natural Rubber Latex ◽  
Mri Contrast Agent ◽  
Rubber Latex ◽  
Mri Contrast ◽  
Magnetic Fe3o4 Nanoparticles ◽  
Magnetic Fe3o4

Ultrasmall Fe@Fe3O4 nanoparticles as T1–T2 dual-mode MRI contrast agents for targeted tumor imaging

2021 ◽  
Vol 32 ◽  
pp. 102335
Author(s):  
Donglin Liu ◽  
Jiaojiao Li ◽  
Chengbin Wang ◽  
Lu An ◽  
Jiaomin Lin ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Tumor Imaging ◽  
Mri Contrast Agents ◽  
Dual Mode ◽  
Mri Contrast

scholarly journals Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2291 ◽  
Author(s):  
Didar Asik ◽  
Rachel Smolinski ◽  
Samira M. Abozeid ◽  
Travis B. Mitchell ◽  
Steven G. Turowski ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Variable Temperature ◽  
Extracellular Fluid ◽  
Bulk Water ◽  
Mri Contrast Agents ◽  
Hydroxyl Group ◽  
Hydroxyl Groups ◽  
Sulfonate Group ◽  
Mri Contrast ◽  
Electrode Potentials

Complexes of Fe(III) that contain a triazacyclononane (TACN) macrocycle, two pendant hydroxyl groups, and a third ancillary pendant show promise as MRI contrast agents. The ancillary group plays an important role in tuning the solution relaxivity of the Fe(III) complex and leads to large changes in MRI contrast enhancement in mice. Two new Fe(III) complexes, one with a third coordinating hydroxypropyl pendant, Fe(L2), and one with an anionic non-coordinating sulfonate group, Fe(L1)(OH2), are compared. Both complexes have a deprotonated hydroxyl group at neutral pH and electrode potentials representative of a stabilized trivalent iron center. The r1 relaxivity of the Fe(L1)(OH2) complex is double that of the saturated complex, Fe(L2), at 4.7 T, 37 °C in buffered solutions. However, variable-temperature 17O-NMR experiments show that the inner-sphere water of Fe(L1)(OH2) does not exchange rapidly with bulk water under these conditions. The pendant sulfonate group in Fe(L1)(OH2) confers high solubility to the complex in comparison to Fe(L2) or previously studied analogues with benzyl groups. Dynamic MRI studies of the two complexes showed major differences in their pharmacokinetics clearance rates compared to an analogue containing a benzyl ancillary group. Rapid blood clearance and poor binding to serum albumin identify Fe(L1)(OH2) for development as an extracellular fluid contrast agent.

Cubosomes as Carriers for MRI Contrast Agents

2017 ◽  
Vol 24 (5) ◽  
pp. 470-482 ◽  
Author(s):  
Nicolas Alcaraz ◽  
Ben J. Boyd
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

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