scholarly journals Alternative test methods for (nano)materials hazards assessment: Challenges and recommendations for regulatory preparedness

Nano Today ◽  
2021 ◽  
Vol 40 ◽  
pp. 101242
Author(s):  
Susana I.L. Gomes ◽  
Janeck J. Scott-Fordsmand ◽  
Monica J.B. Amorim
Keyword(s):  
Test Methods ◽  
Nano Materials ◽  
Hazards Assessment ◽  
Alternative Test

Validation and Regulatory Acceptance of Alternative Test Methods

2003 ◽  
Author(s):  
Michael Balls ◽  
Julia Fentem
Keyword(s):  
Test Methods ◽  
Alternative Test ◽  
Regulatory Acceptance

scholarly journals Roadmap for the development of alternative test methods

2020 ◽  
Vol 94 (10) ◽  
pp. 3597-3598
Author(s):  
Tim Brecklinghaus
Keyword(s):  
Test Methods ◽  
Alternative Test

scholarly journals Book Reviews: The History of Alternative Test Methods in Toxicology

2019 ◽  
Vol 38 (3) ◽  
pp. 235-235
Author(s):  
John A. Budny
Keyword(s):  
Test Methods ◽  
History Of ◽  
Alternative Test

Quality Assurance for In Vitro Alternative Test Methods: Quality Control Issues in Test Kit Production

2004 ◽  
Vol 32 (1_suppl) ◽  
pp. 725-729 ◽  
Author(s):  
Amy Rispin ◽  
John W. Harbell ◽  
Mitchell Klausner ◽  
Foster T. Jordan ◽  
Sandra Coecke ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Test Methods ◽  
Test Kit ◽  
Alternative Test

scholarly journals Skin Sensitization Potential and Cellular ROS-Induced Cytotoxicity of Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2140
Author(s):  
Sung-Hyun Kim ◽  
Dong Han Lee ◽  
SeoYoon Choi ◽  
Jun-Young Yang ◽  
Kikyung Jung ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Test Methods ◽  
Skin Sensitization ◽  
Accurate Identification ◽  
Silica Nanomaterials ◽  
High Protein Binding ◽  
In Vivo Analysis ◽  
Alternative Test

Nowadays, various industries using nanomaterials are growing rapidly, and in particular, as the commercialization and use of nanomaterials increase in the cosmetic field, the possibility of exposure of nanomaterials to the skin of product producers and consumers is increasing. Due to the unique properties of nanomaterials with a very small size, they can act as hapten and induce immune responses and skin sensitization, so accurate identification of toxicity is required. Therefore, we selected silica nanomaterials used in various fields such as cosmetics and biomaterials and evaluated the skin sensitization potential step-by-step according to in-vitro and in-vivo alternative test methods. KeratinoSensTM cells of modified keratinocyte and THP-1 cells mimicking dendritic-cells were treated with silica nanoparticles, and their potential for skin sensitization and cytotoxicity were evaluated, respectively. We also confirmed the sensitizing ability of silica nanoparticles in the auricle-lymph nodes of BALB/C mice by in-vivo analysis. As a result, silica nanoparticles showed high protein binding and reactive oxygen species (ROS) mediated cytotoxicity, but no significant observation of skin sensitization indicators was observed. Although more studies are needed to elucidate the mechanism of skin sensitization by nanomaterials, the results of this study showed that silica nanoparticles did not induce skin sensitization.

scholarly journals Alternative test methods, declaration of capacity och test of heat pumps in multiple climates zones – A Nordsyn study on heat pumps in the context of Ecodesign and Energy labelling​

2021 ◽  
Author(s):  
Ola Gustafsson ◽  
Elvira Lindeblom ◽  
Tommy Walfridson ◽  
Anton Falk ◽  
Caroline Haglund Stignor
Keyword(s):  
Heat Pumps ◽  
Test Methods ◽  
Alternative Test ◽  
Energy Labelling

Basic NDE of Some Nano Composites

2002 ◽  
Author(s):  
Emmanuel Ayorinde ◽  
Sadikul Islam ◽  
Hassan Mahfuz ◽  
Ronald Gibson ◽  
Feizhong Deng ◽  
...  
Keyword(s):  
Acoustic Emission ◽  
Composite Structures ◽  
Mechanical Test ◽  
Test Methods ◽  
Nano Composites ◽  
Nano Materials ◽  
Sandwich Composites ◽  
The World ◽  
The Matrix ◽  
Slender Structures

The influence of the nano-sized particulate or slender structures admixed into the material of regular composite structures of various architectures is being enthusiastically studied in many places across the world, but the study is yet in its infancy because there are so many aspects to be investigated. This work is basically on foam-cored structural sandwich composites, and even here there are many variables involved, for example the nano-enhancer can be introduced into the reinforcement, the matrix or the foam. The focus of the work is on some possible effects of the presence of the nano-materials on the NDE process in testing these composites. Acoustic emission is emphasized in these studies, as it appears to hold promise for non-destructively testing materials of this nature, and basic and standard mechanical test methods are employed.

Sign in / Sign up

Export Citation Format

Share Document