scholarly journals Striatal cholinergic interneuron numbers are increased in a rodent model of dystonic cerebral palsy

2020 ◽  
Vol 144 ◽  
pp. 105045
Author(s):  
Sushma Gandham ◽  
Yearam Tak ◽  
Bhooma R. Aravamuthan
2020 ◽  
Author(s):  
Sushma Gandham ◽  
Yearam Tak ◽  
Bhooma R. Aravamuthan

AbstractNeonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whether striatal ChI pathology is also associated with dystonia following neonatal brain injury. We used unbiased stereology to estimate striatal ChI and parvalbumin-positive GABAergic interneuron (PVI) numbers in a rodent model of neonatal brain injury that demonstrates electrophysiological markers of dystonia and spasticity. Striatal ChI numbers are increased following neonatal brain injury while PVI numbers are unchanged. These numbers do not correlate with electrophysiologic measures of dystonia severity. This suggests that striatal ChI pathology, though present, may not be the primary pathophysiologic contributor to dystonia following neonatal brain injury. Increased striatal ChI numbers could instead represent a passenger or protective phenomenon in the setting of dystonic CP.


2020 ◽  
Vol 134 ◽  
pp. 104711 ◽  
Author(s):  
Bhooma R. Aravamuthan ◽  
Sushma Gandham ◽  
Anne B. Young ◽  
Seward B. Rutkove

2017 ◽  
Vol 128 ◽  
pp. 58-67 ◽  
Author(s):  
André L.F. Meireles ◽  
Marília R. Marques ◽  
Ethiane Segabinazi ◽  
Christiano Spindler ◽  
Francele V. Piazza ◽  
...  

2008 ◽  
Vol 1222 ◽  
pp. 129-140 ◽  
Author(s):  
Simone Marcuzzo ◽  
Márcio Ferreira Dutra ◽  
Felipe Stigger ◽  
Patrícia Severo do Nascimento ◽  
Jocemar Ilha ◽  
...  

2010 ◽  
Vol 19 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Guro Andersen ◽  
Tone R. Mjøen ◽  
Torstein Vik

Abstract This study describes the prevalence of speech problems and the use of augmentative and alternative communication (AAC) in children with cerebral palsy (CP) in Norway. Information on the communicative abilities of 564 children with CP born 1996–2003, recorded in the Norwegian CP Registry, was collected. A total of 270 children (48%) had normal speech, 90 (16%) had slightly indistinct speech, 52 (9%) had indistinct speech, 35 (6%) had very indistinct speech, 110 children (19%) had no speech, and 7 (1%) were unknown. Speech problems were most common in children with dyskinetic CP (92 %), in children with the most severe gross motor function impairments and among children being totally dependent on assistance in feeding or tube-fed children. A higher proportion of children born at term had speech problems when compared with children born before 32 weeks of gestational age 32 (p > 0.001). Among the 197 children with speech problems only, 106 (54%) used AAC in some form. Approximately 20% of children had no verbal speech, whereas ~15% had significant speech problems. Among children with either significant speech problems or no speech, only 54% used AAC in any form.


2007 ◽  
Vol 41 (10) ◽  
pp. 46
Author(s):  
ALEC HOON
Keyword(s):  

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