Effects of sensorimotor restriction and anoxia on gait and motor cortex organization: Implications for a rodent model of cerebral palsy

AbstractNeonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whether striatal ChI pathology is also associated with dystonia following neonatal brain injury. We used unbiased stereology to estimate striatal ChI and parvalbumin-positive GABAergic interneuron (PVI) numbers in a rodent model of neonatal brain injury that demonstrates electrophysiological markers of dystonia and spasticity. Striatal ChI numbers are increased following neonatal brain injury while PVI numbers are unchanged. These numbers do not correlate with electrophysiologic measures of dystonia severity. This suggests that striatal ChI pathology, though present, may not be the primary pathophysiologic contributor to dystonia following neonatal brain injury. Increased striatal ChI numbers could instead represent a passenger or protective phenomenon in the setting of dystonic CP.

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Treadmill training combined with transcranial direct current stimulation over the primary motor cortex in a child with cerebral palsy and hydrocephalus: A case report.

Manual Therapy Posturology & Rehabilitation Journal ◽

10.17784/mtprehabjournal.2014.12.210 ◽

2014 ◽

Vol 12 ◽

pp. 210

Author(s):

Fernanda Lobo Rezende ◽

Natália De Almeida Carvalho Duarte ◽

Luanda André Collange Grecco ◽

Claudia Santos Oliveira

Keyword(s):

Cerebral Palsy ◽

Motor Cortex ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Primary Motor Cortex ◽

Treadmill Training ◽

Anodal Tdcs ◽

Direct Current Stimulation ◽

Eyes Closed ◽

Intervention Protocol

Introduction: Transcranial direct current stimulation (tDCS) is a promising technique that stimulates the cortex with a direct, low-intensity electric current and can potentiate motor learning. Objective: Describe the results of an intervention protocol involving anodal stimulation over the primary motor cortex combined with treadmill training in a child with cerebral palsy. Method: The intervention was comprised of ten sessions of anodal tDCS (1mA) over the primary motor cortex during the treadmill training. Stabilometric analysis was evaluated one week before and one week after the intervention. Results: A reduction in oscillations of the COP was found under both conditions (eyes opened and eyes closed. Conclusion: Our findings suggest that anodal tDCS over primary motor cortex can potentiate the results of treadmill training.

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Sex may influence motor phenotype in a novel rodent model of cerebral palsy

Neurobiology of Disease ◽

10.1016/j.nbd.2019.104711 ◽

2020 ◽

Vol 134 ◽

pp. 104711 ◽

Cited By ~ 4

Author(s):

Bhooma R. Aravamuthan ◽

Sushma Gandham ◽

Anne B. Young ◽

Seward B. Rutkove

Keyword(s):

Cerebral Palsy ◽

Rodent Model ◽

Motor Phenotype

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