Increased phosphorylated-μ-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation

2004 ◽  
Vol 354 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Minoru Narita ◽  
Naoko Kuzumaki ◽  
Masami Suzuki ◽  
Michiko Narita ◽  
Kousei Oe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sciatic Nerve ◽  
Opioid Receptor ◽  
Mouse Spinal Cord ◽  
Μ Opioid Receptor

Distinct physiological role of amidino-TAPA-sensitive and DAMGO-insensitive μ-opioid receptor splice variants in the mouse spinal cord

2013 ◽  
Vol 711 (1-3) ◽  
pp. 80-86 ◽  
Author(s):  
Hirokazu Mizoguchi ◽  
Chizuko Watanabe ◽  
Takayuki Higashiya ◽  
Satoshi Takeda ◽  
Kaori Moriyama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Opioid Receptor ◽  
Splice Variants ◽  
Physiological Role ◽  
Mouse Spinal Cord ◽  
Μ Opioid Receptor

scholarly journals Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord

Neuroreport ◽  
2012 ◽  
Vol 23 (6) ◽  
pp. 378-384 ◽  
Author(s):  
Sheng-Chin Kao ◽  
Xiuli Zhao ◽  
Chun-Yi Lee ◽  
Fidelis E. Atianjoh ◽  
Estelle B. Gauda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mrna Expression ◽  
Opioid Receptor ◽  
Rat Spinal Cord ◽  
Receptor Mrna ◽  
Μ Opioid Receptor

scholarly journals Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ-Opioid Receptors in the Spinal Cord of Mice

2012 ◽  
Vol 117 (4) ◽  
pp. 847-856 ◽  
Author(s):  
Masami Suzuki ◽  
Minoru Narita ◽  
Minami Hasegawa ◽  
Sadayoshi Furuta ◽  
Tomoyuki Kawamata ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Abdominal Pain ◽  
Substance P ◽  
Peritoneal Carcinomatosis ◽  
Opioid Receptor ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Receptor Expression ◽  
Tumor Bearing ◽  
Μ Opioid Receptor

Background Patients with peritoneal carcinomatosis often report abdominal pain, which is relatively refractory to morphine. It has been considered that a new animal model is required to investigate the mechanism of abdominal pain for the development of optimal treatments for this type of pain. Methods To prepare a peritoneal carcinomatosis model, highly peritoneal-seeding gastric cancer cells, 60As6, were implanted into the abdominal cavity. The nociceptive modality for pain-related behavior was assessed in terms of withdrawal behavior in response to mechanical stimuli and hunching behavior. Tissue samples from mouse dorsal root ganglia and spinal cord were subject to immunohistochemistry and real-time reverse transcription polymerase chain reaction. Results Mice with peritoneal dissemination showed significant hypersensitivity of the abdomen to mechanical stimulation and spontaneous visceral pain-related behavior. There was a significant increase in c-Fos-positive cells in the spinal cord in tumor-bearing mice. Those mice exhibited a remarkable increase in substance P-positive neurons in the dorsal root ganglia (control vs. tumor, 15.4 ± 1.1 vs. 24.2 ± 3.6, P < 0.05, n = 3). A significant decreases in μ-opioid receptor expression mainly in substance P-positive neurons was observed in tumor-bearing mice (69.3 ± 4.9 vs. 38.7 ± 0.9, P < 0.05, n = 3), and a relatively higher dose of morphine was required to significantly reverse the abdominal hypersensitivity. Conclusion Both the up-regulation of substance P and down-regulation of μ-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis.

scholarly journals Absence of G-protein activation by μ-opioid receptor agonists in the spinal cord of μ-opioid receptor knockout mice

1999 ◽  
Vol 126 (2) ◽  
pp. 451-456 ◽  
Author(s):  
Minoru Narita ◽  
Hirokazu Mizoguchi ◽  
Michiko Narita ◽  
Ichiro Sora ◽  
George R Uhl ◽  
...  
Keyword(s):  
Spinal Cord ◽  
G Protein ◽  
Opioid Receptor ◽  
Knockout Mice ◽  
Protein Activation ◽  
Receptor Agonists ◽  
G Protein Activation ◽  
Μ Opioid Receptor ◽  
Opioid Receptor Agonists

Peripheral axonal injury results in reduced μ opioid receptor pre- and post-synaptic action in the spinal cord☆

Pain ◽  
2005 ◽  
Vol 117 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Tatsuro Kohno ◽  
Ru-Rong Ji ◽  
Nobuko Ito ◽  
Andrew J. Allchorne ◽  
Katia Befort ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Opioid Receptor ◽  
Axonal Injury ◽  
Synaptic Action ◽  
Μ Opioid Receptor
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