Brain-derived neurotrophic factor serum concentrations are increased in drug-naïve schizophrenic patients with chronic cannabis abuse and multiple substance abuse

2004 ◽  
Vol 371 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Maria C. Jockers-Scherübl ◽  
Heidi Danker-Hopfe ◽  
Richard Mahlberg ◽  
Franziska Selig ◽  
Johannes Rentzsch ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Serum Concentrations ◽  
Cannabis Abuse ◽  
Multiple Substance ◽  
Schizophrenic Patients ◽  
Drug Naïve

Cannabis and multiple substance abuse raise the serum concentrations of the neurotrophins NGF and BDNF in drug-naïve schizophrenic patients

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
MC Jockers-Scherübl ◽  
U Matthies ◽  
H Danker-Hopfe ◽  
F Selig ◽  
R Mahlberg ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Serum Concentrations ◽  
Multiple Substance ◽  
Schizophrenic Patients ◽  
Drug Naïve

Chronic Cannabis Abuse Raises Nerve Growth Factor Serum Concentrations in Drug-Naive Schizophrenic Patients

2003 ◽  
Vol 17 (4) ◽  
pp. 439-445 ◽  
Author(s):  
Maria C. Jockers-ScherüBl ◽  
Uta Matthies ◽  
Heidi Danker-Hopfe ◽  
Undine E. Lang ◽  
Richard Mahlberg ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Serum Concentrations ◽  
Nerve Growth ◽  
Cannabis Abuse ◽  
Schizophrenic Patients ◽  
Drug Naïve

Serum concentrations of brain-derived neurotrophic factor (BDNF) are decreased in colorectal cancer patients

2013 ◽  
Vol 13 (2) ◽  
pp. 67-73 ◽  
Author(s):  
G.V. Brierley ◽  
I.K. Priebe ◽  
L. Purins ◽  
K.Y.C. Fung ◽  
B. Tabor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Serum Concentrations ◽  
Colorectal Cancer Patients

scholarly journals Investigating the link between serum concentrations of brain-derived neurotrophic factor and behavioral measures in anxious alcohol-dependent individuals

Alcohol ◽  
2020 ◽  
Vol 89 ◽  
pp. 75-83
Author(s):  
Jeanelle Portelli ◽  
Mehdi Farokhnia ◽  
Sara L. Deschaine ◽  
Jillian T. Battista ◽  
Mary R. Lee ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Serum Concentrations ◽  
Behavioral Measures ◽  
Alcohol Dependent

Brain-derived neurotrophic factor and electroconvulsive therapy in a schizoaffective patient with treatment-resistant paranoid-hallucinatory symptoms

2011 ◽  
Vol 26 (S2) ◽  
pp. 1148-1148
Author(s):  
G. Martinotti ◽  
V. Ricci ◽  
M. Di Nicola ◽  
C. Caltagirone ◽  
P. Bria ◽  
...  
Keyword(s):  
Case Report ◽  
Electroconvulsive Therapy ◽  
Neurotrophic Factor ◽  
Poor Response ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Treatment Resistant ◽  
Schizophrenic Patients ◽  
General Improvement ◽  
The Relationship

It has been proposed that deficits in the production and the utilization of brain-derived neurotrophic factor (BDNF) may contribute to the pathogenesis of schizophrenia. At the same time, electroconvulsive therapy (ECT) has been shown to induce a robust increase of BDNF protein in animal models. These findings suggest that one putative mechanism of action of ECT is the regulation of BDNF and/or related neurotrophins. In this case report a 54-year-old man with severe treatment-resistant schizophrenic symptoms was treated with ECT. In order to evaluate the effect of ECT on BDNF serum levels, we collected a blood sample before each ECT session. During the course of ECT treatment the paranoid and hallucinatory symptoms gradually improved while BDNF levels increased over time. In addition, there was a general improvement of its positive and negative schizophrenic symptoms and depressive state.In conclusion, this case report further validates the therapeutic efficacy of ECT in schizophrenic patients with inadequate or poor response to traditional treatments. Moreover, ECT therapeutic effect is associated with an increase in BDNF serum levels. Further studies are needed to characterize the relationship between BDNF and ECT in patients with schizophrenia symptoms.

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