Ischemic injury decreases parvalbumin expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells

2012 ◽  
Vol 512 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Phil-Ok Koh
Keyword(s):  
Animal Model ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Ischemic Injury ◽  
Artery Occlusion ◽  
Ht22 Cells ◽  
Cerebral Artery Occlusion

scholarly journals Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion

2019 ◽  
Vol 11 (3) ◽  
pp. 468-480 ◽  
Author(s):  
Mohammed Salman Shazeeb ◽  
Robert M. King ◽  
Olivia W. Brooks ◽  
Ajit S. Puri ◽  
Nils Henninger ◽  
...  
Keyword(s):  
Animal Model ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Large Animal Model ◽  
Large Animal ◽  
Cerebral Artery Occlusion

scholarly journals A Comparative Study of Variables Influencing Ischemic Injury in the Longa and Koizumi Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148503 ◽  
Author(s):  
Gary P. Morris ◽  
Amanda L. Wright ◽  
Richard P. Tan ◽  
Amadeus Gladbach ◽  
Lars M. Ittner ◽  
...  
Keyword(s):  
Comparative Study ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Ischemic Injury ◽  
Artery Occlusion ◽  
Cerebral Artery Occlusion

NF-κB protects neurons from ischemic injury after middle cerebral artery occlusion in mice

2006 ◽  
Vol 1088 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Edward A.M. Duckworth ◽  
Tanya Butler ◽  
Lisa Collier ◽  
Shane Collier ◽  
Keith R. Pennypacker
Keyword(s):  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Ischemic Injury ◽  
Artery Occlusion ◽  
Cerebral Artery Occlusion

scholarly journals Reperfusion-Induced Temporary Appearance of Therapeutic Window in Penumbra after 2 h of Photothrombotic Middle Cerebral Artery Occlusion in Rats

2008 ◽  
Vol 29 (3) ◽  
pp. 565-574 ◽  
Author(s):  
Hiroshi Yao ◽  
Narihiko Yoshii ◽  
Toshiaki Akira ◽  
Tatsuo Nakahara
Keyword(s):  
Middle Cerebral Artery ◽  
Water Content ◽  
Middle Cerebral Artery Occlusion ◽  
Brain Tissue ◽  
Cerebral Artery ◽  
Ischemic Injury ◽  
Artery Occlusion ◽  
Male Rats ◽  
Ischemic Core ◽  
Cerebral Artery Occlusion

To explore the effects of reperfusion on evolution of focal ischemic injury, spontaneously hypertensive male rats were subjected to photothrombotic distal middle cerebral artery occlusion (MCAO) with or without YAG laser-induced reperfusion. The volume of fodrin breakdown zone, water content, and brain tissue levels of sodium (Na+) and potassium (K+) were measured in the ischemic core and penumbra. Reperfusion attenuated fodrin breakdown, and the volume containing fodrin breakdown product at 3 h after reperfusion (5 h after MCAO) (30±7 mm3) was significantly smaller than the 42±3 mm3 of the permanent occlusion group. After 3 to 6 h of ischemia, Na+ increased, and K+ decreased in the ischemic core. Reperfusion after 2 h of MCA occlusion did not mitigate the ischemia-induced changes in brain tissue electrolytes and water content at 3 to 6 h of ischemia. Even in reperfusion after comparatively long periods of occlusion where brain infarction size, assessed 3 days after MCAO, was not significantly reduced by reperfusion, and the precipitating indicators of the ischemic core (Na+, K+, water content) did not improve, temporary improvement or a delay in progression of ischemic injury was discernible in the penumbra. These results indicate the possibility that treatment with reperfusion is permissive to the effects of neuroprotection.

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