scholarly journals Microencapsulated Schwann cell transplantation inhibits P2X2/3 receptors overexpression in a sciatic nerve injury rat model with neuropathic pain

2018 ◽  
Vol 676 ◽  
pp. 51-57 ◽  
Author(s):  
Ya-ling Zhang ◽  
Yi-guo Liu ◽  
De-jian Chen ◽  
Bao-lin Yang ◽  
Tao-tao Liu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Schwann Cell ◽  
Nerve Injury ◽  
Cell Transplantation ◽  
Rat Model ◽  
Sciatic Nerve Injury

Spinal P2X7 receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model

2012 ◽  
Vol 226 (1) ◽  
pp. 163-170 ◽  
Author(s):  
Wen-Juan He ◽  
Jian Cui ◽  
Lu Du ◽  
Yan-Dong Zhao ◽  
Geoffrey Burnstock ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Rat Model ◽  
P2x7 Receptor ◽  
Sciatic Nerve Injury ◽  
Microglia Activation

Involvement of protein isoprenylation in neuropathic pain induced by sciatic nerve injury in mice

2014 ◽  
Vol 564 ◽  
pp. 27-31 ◽  
Author(s):  
Masahiro Ohsawa ◽  
Junpei Mutoh ◽  
Shohei Yamamoto ◽  
Hiroaki Hisa
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Protein Isoprenylation

The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model

2020 ◽  
Vol 34 (4) ◽  
pp. 397-401
Author(s):  
Mehmet Fatih Korkmaz ◽  
Hakan Parlakpinar ◽  
Mehmet Nuri Erdem ◽  
Mehmet Fethi Ceylan ◽  
Levent Ediz ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Injury ◽  
Rat Model ◽  
Therapeutic Efficacy ◽  
Sciatic Nerve Injury

Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3

2015 ◽  
Vol 53 (8) ◽  
pp. 5129-5139 ◽  
Author(s):  
Chun Yao ◽  
Xiangxiang Shi ◽  
Zhanhu Zhang ◽  
Songlin Zhou ◽  
Tianmei Qian ◽  
...  
Keyword(s):  
Cell Migration ◽  
Sciatic Nerve ◽  
Schwann Cell ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Schwann Cell Migration

scholarly journals Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury

2021 ◽  
Vol 16 (8) ◽  
pp. 1622
Author(s):  
Hai-Lin Xu ◽  
Yu-Hui Kou ◽  
Yu-Song Yuan ◽  
Fei Yu ◽  
Ya-Jun Zhang ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Nerve Injury ◽  
Rat Model ◽  
Nerve Repair ◽  
Sciatic Nerve Injury

scholarly journals The Application of Pulsed Radiofrequency to Dorsal Root Ganglion Ameliorates Neuropathic Pain by Reducing CCL2 Expression in the Early Stage After Sciatic Nerve Injury in Rats

2020 ◽  
Author(s):  
Cheng-Fu wan ◽  
Bo-Han zhang ◽  
Dao-Song Dong ◽  
Tao Song
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Dorsal Root ◽  
Early Stage ◽  
Sciatic Nerve Injury ◽  
Pulsed Radiofrequency ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Ccl2 Expression

Abstract Background: Neuropathic pain (NP) can be treated effectively using pulsed radiofrequency (PRF). NP development and maintenance involves the essential neurotransmitter chemokine c-c motif ligand 2 (CCL2). The present study aimed to determine whether PRF regulated CCL2 expression in sciatic nerve injury (SNI) model rats.Methods: Sprague-Dawley rats were divided randomly into a sham group, an SNI group, and a PRF group. In the PRF group, L5 dorsal root ganglia received PRF treatment. After paw withdrawal mechanical threshold (PWMT) was examined, the expression levels of CCL2 and nuclear factor kappa B (NF-κB) in spinal dorsal horn were determined.Results: The PWMT in PRF group increased significantly compared with that of the SNI group (P < 0.05). The CCL2 and NF-κB expression levels in the PRF group were significant lower than those in the SNI group (P < 0.05).Conclusion: NP was effectively alleviated by PRF-mediated reductions in CCL2 expression via inhibition of NF-κB activation in the spinal cord of SNI model rats.

scholarly journals The Effect of Prior Nerve Block on Neuropathic Pain Induced by Partial Sciatic Nerve Injury in Rats

PAIN RESEARCH ◽  
1997 ◽  
Vol 12 (2) ◽  
pp. 131-137
Author(s):  
Takumi Nagaro ◽  
Kazushi Takaishi ◽  
Hitoshi Kojo ◽  
Elizabeth A Disbrow ◽  
John H Eisele
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Nerve Block ◽  
Sciatic Nerve Injury
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