Maternal high-fat diet increases anhedonic behavior and modulates hippocampal Mash1 and BDNF expression in adult offspring

2021 ◽  
Vol 764 ◽  
pp. 136239
Author(s):  
Haidar Tafner Curi ◽  
Clarissa Tavares Dias ◽  
Maria Laura Monteiro da Luz Camargo ◽  
Paula dos Santos Gomez ◽  
Moisés Felipe Pereira Gomes ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adult Offspring ◽  
High Fat ◽  
Bdnf Expression

Maternal high fat diet (HFD) in the adult offspring brain modifies cell density and neuronal density

2016 ◽  
Author(s):  
Diego Ojeda Pedraza ◽  
Kate Jane-Coupe ◽  
Megan Earl ◽  
Oliver Hutton ◽  
Judith Eckert ◽  
...  
Keyword(s):  
Cell Density ◽  
High Fat Diet ◽  
Adult Offspring ◽  
High Fat ◽  
Neuronal Density

Maternal high fat diet programs stress-induced behavioral disorder in adult offspring

2015 ◽  
Vol 152 ◽  
pp. 119-127 ◽  
Author(s):  
ChengCheng Lin ◽  
Bei Shao ◽  
HuanJie Huang ◽  
YuLei Zhou ◽  
YuanShao Lin
Keyword(s):  
High Fat Diet ◽  
Behavioral Disorder ◽  
Adult Offspring ◽  
High Fat

Effects of maternal high-fat diet and sedentary lifestyle on susceptibility of adult offspring to ozone exposure in rats

2017 ◽  
Vol 29 (6) ◽  
pp. 239-254 ◽  
Author(s):  
C. J. Gordon ◽  
P. M. Phillips ◽  
A. F. M. Johnstone ◽  
J. Schmid ◽  
M. C. Schladweiler ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Sedentary Lifestyle ◽  
Ozone Exposure ◽  
Adult Offspring ◽  
High Fat

scholarly journals Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

2020 ◽  
Author(s):  
Vanesa Izquierdo ◽  
Verónica Palomera-Ávalos ◽  
Mercè Pallàs ◽  
Christian Griñán-Ferré
Keyword(s):  
Gene Expression ◽  
Cognitive Decline ◽  
High Fat Diet ◽  
Epigenetic Inheritance ◽  
Adult Offspring ◽  
High Fat ◽  
Molecular Alterations ◽  
Protein Levels ◽  
Age Related ◽  
Inflammatory Profile

Environmental factors as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. The epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol HFD+RV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RV groups and their offspring. Molecularly, a significant increase in 5-mC levels, as well as increased gene expression of Dnmt1 and Dnmt3a in HFD+RV F1 group, were found. Furthermore, a significantly increased of m6A levels in HFD+RV F1 were found, and there were changes in gene expression of its enzymes (Mettl3 and Fto). Moreover, we found a decrease in gene expression levels of pro-inflammatory markers such as Il1-β, Il-6, Tnf-α, Cxcl-10, Mcp-1 and Tgf-β1 in HFD+RV and HFD+RV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Ngf and Nt3 and its receptors TrkA and TrkB. Likewise, an increase in protein levels of BDNF and p-Akt in HFD+RV F1 was found. These results suggest that maternal RV supplementation under HFD intake prevents cognitive decline in SAMP8 adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, restoring the epigenetic landscape as well as synaptic plasticity.

scholarly journals Paternal High Fat Diet in Rats Leads to Renal Accumulation of Lipid and Tubular Changes in Adult Offspring

Nutrients ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 521 ◽  
Author(s):  
Sabiha Chowdhury ◽  
Virginie Lecomte ◽  
Jonathan Erlich ◽  
Christopher Maloney ◽  
Margaret Morris
Keyword(s):  
High Fat Diet ◽  
Adult Offspring ◽  
High Fat

Maternal high-fat diet increases vascular contractility in adult offspring in a sex-dependent manner

2020 ◽  
Vol 44 (1) ◽  
pp. 36-46
Author(s):  
Fangyuan Chen ◽  
Kaifang Cao ◽  
Haichuan Zhang ◽  
Haili Yu ◽  
Yinghua Liu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adult Offspring ◽  
Dependent Manner ◽  
High Fat ◽  
Vascular Contractility

The impact of maternal high-fat feeding on liver and abdominal fat accumulation in adult offspring under a long-term high-fat diet

Hepatology ◽  
2009 ◽  
Vol 51 (6) ◽  
pp. 2234-2235 ◽  
Author(s):  
Adriana L. Burgueño ◽  
Julieta Carabelli ◽  
Silvia Sookoian ◽  
Carlos J. Pirola
Keyword(s):  
High Fat Diet ◽  
Abdominal Fat ◽  
Adult Offspring ◽  
High Fat ◽  
Fat Accumulation ◽  
The Impact ◽  
Fat Feeding

Maternal high-fat diet promotes calcified atherosclerotic plaque formation in adult offspring by enhancing transformation of vascular smooth muscle cells to osteochondrocytic-like phenotype

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Miyawaki ◽  
H Yamada ◽  
H Kubota ◽  
T Sugimoto ◽  
M Saburi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
High Fat Diet ◽  
Fold Increase ◽  
Plaque Formation ◽  
Adult Offspring ◽  
Plaque Size ◽  
High Fat ◽  
Osteogenic Activity

Abstract Background and objective Maternal high-fat diet (HFD) has been shown to modulate vascular function and remodeling in adult offspring. Atherosclerotic vascular calcification is closely associated with the onset of cardiovascular event. We therefore investigated the impact of maternal HFD on calcification of atherogenic plaques. Methods and results Eight-week-old female apo-E−/− mice (C57BL/6) were fed an HFD or a normal diet (ND) one week prior to mating, and the diet was continued throughout gestation and lactation. Offspring of both groups were fed a high-cholesterol diet (HCD) from 8 weeks of age. Ex vivo osteogenic activity of aortic root and aortic arch was analyzed using in vivo imaging system (IVIS) with OsteoSense 680. Sixteen-week-old male offspring of HFD-fed dams (O-HFD) showed a 1.4-fold increase in fluorescent intensity compared with those of ND-fed dams (O-ND) (p<0.05). Likewise, female O-HFD showed a significantly increased osteogenic activity in aortic arch (154%, p<0.05). Percentages of plaque area and oil red O-positive area were comparable between O-ND and O-HFD of both genders, suggesting that augmented osteogenic activity in O-HFD is not dependent on the plaque size. To investigate the underlying mechanism of augmented calcified plaque formation in O-HFD, vascular smooth muscle cells (VSMCs) of thoracic aorta form 8-week-old male offspring were primarily cultured and VSMCs calcification was induced by treatment with calcification media supplemented with phosphate (2.6 mM). Alizarin-red-positive area upon 10 days stimulation showed a 3.4-fold increase in VSMCs from O-HFD compared with that from O-ND (p<0.01). Consistently, western blotting analysis revealed that expression level of osteocalcin was significantly higher in O-HFD than O-ND, suggesting that osteochondrocytic transformation of VSMCs is augmented in O-HFD. Conclusion Our findings demonstrate that maternal HFD accelerates the development of atherogenic calcification independent of plaque size. In vitro transformation to osteochondrocytic-like cells is enhanced in VSMCs from offspring of HFD-fed dams. Inhibition of VSMCs skewing toward osteochondrocytic-like cells could be a potential therapeutic target for preventing the development of atherosclerotic vascular calcification. Funding Acknowledgement Type of funding source: None

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