Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

Amyloid Β ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Secretase Activity

α7 nicotinic acetylcholine receptor-specific stimulation ameliorates cognitive impairment in a mouse model of Alzheimer's disease via suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_or4-4 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. OR4-4

Author(s):

Kazuyuki Takata ◽

Shohei Kawanishi ◽

Eriko Kuroda ◽

Shigehiko Takegami ◽

Tatsuya Kitade ◽

...

Keyword(s):

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Amyloid Β ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Secretase Activity ◽

Specific Stimulation

Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer’s Disease

Molecular Imaging and Biology ◽

10.1007/s11307-018-1253-4 ◽

2018 ◽

Vol 21 (3) ◽

pp. 519-528 ◽

Cited By ~ 1

Author(s):

Yuki Matsuura ◽

Masashi Ueda ◽

Yusuke Higaki ◽

Kohei Sano ◽

Hideo Saji ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

The Relationship

Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

Journal of Neuroscience ◽

10.1523/jneurosci.6159-08.2009 ◽

2009 ◽

Vol 29 (27) ◽

pp. 8805-8815 ◽

Cited By ~ 123

Author(s):

G. Dziewczapolski ◽

C. M. Glogowski ◽

E. Masliah ◽

S. F. Heinemann

Keyword(s):

Alzheimer’S Disease ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Synaptic Pathology ◽

Acetylcholine Receptor Gene

Preparation of peripheral blood-derived microglia-like cells and its intra-hippocampal injection to ameliorate amyloid-β burden and cognitive impairment in a mouse model of Alzheimer's disease

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.93.0_1-ss-17 ◽

2020 ◽

Vol 93 (0) ◽

pp. 1-SS-17

Author(s):

Eriko Kuroda ◽

Kaneyasu Nishimura ◽

Yuki Toda ◽

Susumu Nakata ◽

Yoshihisa Kitamura ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Peripheral Blood ◽

Amyloid Β ◽

Model Of Alzheimer’S Disease

Faculty Opinions recommendation of The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087058.540025 ◽

2007 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Membrane Lipids ◽

Beta Amyloid ◽

Amyloid Protein ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Beta Amyloid Protein

Virtual screening studies of Chinese medicine Coptidis Rhizoma as alpha7 nicotinic acetylcholine receptor agonists for treatment of Alzheimer’s disease

Journal of Molecular Structure ◽

10.1016/j.molstruc.2015.01.021 ◽

2015 ◽

Vol 1086 ◽

pp. 207-215 ◽

Cited By ~ 7

Author(s):

Li Xiang ◽

Youdong Xu ◽

Yan Zhang ◽

Xianli Meng ◽

Ping Wang

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Chinese Medicine ◽

Virtual Screening ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Receptor Agonists ◽

Coptidis Rhizoma

Peripheral Blood-Derived Microglia-Like Cells Decrease Amyloid-β Burden and Ameliorate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-190974 ◽

2020 ◽

Vol 73 (1) ◽

pp. 413-429 ◽

Cited By ~ 3

Author(s):

Eriko Kuroda ◽

Kazuyuki Takata ◽

Kaneyasu Nishimura ◽

Hikaru Oka ◽

Mari Sueyoshi ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Peripheral Blood ◽

Amyloid Β ◽

Model Of Alzheimer’S Disease

Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer’s disease assessed with positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-010-1644-5 ◽

2010 ◽

Vol 38 (3) ◽

pp. 515-525 ◽

Cited By ~ 78

Author(s):

Kai Kendziorra ◽

Henrike Wolf ◽

Philipp Mael Meyer ◽

Henryk Barthel ◽

Swen Hesse ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Acetylcholine Receptor ◽

Emission Tomography ◽

Nicotinic Acetylcholine ◽

Positron Emission

Preparation of peripheral blood-derived microglia-like cells and its intra-hippocampal injection to ameliorate amyloid-β burden and cognitive impairment in a mouse model of Alzheimer's disease

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.93.0_2-p-148 ◽

2020 ◽

Vol 93 (0) ◽

pp. 2-P-148

Author(s):

Eriko Kuroda ◽

Kaneyasu Nishimura ◽

Yuki Toda ◽

Susumu Nakata ◽

Yoshihisa Kitamura ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Peripheral Blood ◽

Amyloid Β ◽

Model Of Alzheimer’S Disease

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.06.039 ◽

2011 ◽

Vol 82 (8) ◽

pp. 931-942 ◽

Cited By ~ 118

Author(s):

H. Rheinallt Parri ◽

Caterina M. Hernandez ◽

Kelly T. Dineley

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Alpha7 Nicotinic Acetylcholine Receptor

Nicotinic Acetylcholine ◽