α7 nicotinic acetylcholine receptor-specific stimulation ameliorates cognitive impairment in a mouse model of Alzheimer's disease via suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis

Amyloid Β ◽

Nicotinic Acetylcholine ◽

Secretase Activity ◽

Specific Stimulation

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2017.10.021 ◽

2018 ◽

Vol 62 ◽

pp. 197-209 ◽

Cited By ~ 17

Author(s):

Kazuyuki Takata ◽

Takahide Amamiya ◽

Hiroaki Mizoguchi ◽

Shohei Kawanishi ◽

Eriko Kuroda ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Amyloid Β ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Secretase Activity

Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer’s Disease

Molecular Imaging and Biology ◽

10.1007/s11307-018-1253-4 ◽

2018 ◽

Vol 21 (3) ◽

pp. 519-528 ◽

Cited By ~ 1

Author(s):

Yuki Matsuura ◽

Masashi Ueda ◽

Yusuke Higaki ◽

Kohei Sano ◽

Hideo Saji ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

The Relationship

Pharmacological modulation of the α7 nicotinic acetylcholine receptor in a mouse model of mecamylamine-precipitated nicotine withdrawal

Psychopharmacology ◽

10.1007/s00213-018-4879-7 ◽

2018 ◽

Vol 235 (7) ◽

pp. 1897-1905 ◽

Cited By ~ 10

Author(s):

Asti Jackson ◽

Roger L. Papke ◽

M. Imad Damaj

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Nicotinic Acetylcholine ◽

Pharmacological Modulation

Efficacy and Safety of the α7-Nicotinic Acetylcholine Receptor Agonist ABT-126 in the Treatment of Cognitive Impairment Associated With Schizophrenia

The Journal of Clinical Psychiatry ◽

10.4088/jcp.16m11162 ◽

2018 ◽

Vol 79 (3) ◽

Cited By ~ 3

Author(s):

George M. Haig ◽

Deli Wang ◽

Jun Zhao ◽

Ahmed A. Othman ◽

Earle E. Bain

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Efficacy And Safety ◽

Nicotinic Acetylcholine

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

Neuroscience ◽

10.1016/j.neuroscience.2014.08.013 ◽

2014 ◽

Vol 278 ◽

pp. 276-290 ◽

Cited By ~ 21

Author(s):

W.N. Yang ◽

K.G. Ma ◽

X.L. Chen ◽

L.L. Shi ◽

G. Bu ◽

...

Keyword(s):

Protein Kinase ◽

Signaling Pathways ◽

Acetylcholine Receptor ◽

Amyloid Β ◽

Mitogen Activated Protein Kinase ◽

Nicotinic Acetylcholine ◽

Mitogen Activated Protein ◽

Protein Kinase Signaling

α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation

Journal of Neuroinflammation ◽

10.1186/1742-2094-9-98 ◽

2012 ◽

Vol 9 (1) ◽

Cited By ~ 56

Author(s):

Yuan Liu ◽

Jun Hu ◽

Jie Wu ◽

Chenlei Zhu ◽

Yujian Hui ◽

...

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Dopaminergic Neuron ◽

Astrocyte Activation ◽

Nicotinic Acetylcholine ◽

Neuron Loss ◽

Dopaminergic Neuron Loss

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

Psychopharmacology ◽

10.1007/s00213-011-2535-6 ◽

2011 ◽

Vol 220 (4) ◽

pp. 823-833 ◽

Cited By ~ 13

Author(s):

Kathy L. Kohlhaas ◽

Robert S. Bitner ◽

Murali Gopalakrishnan ◽

Lynne E. Rueter

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Antipsychotic Efficacy

α7 Nicotinic Acetylcholine Receptor Agonism Confers Neuroprotection Through GSK-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage

Stroke ◽

10.1161/strokeaha.111.639989 ◽

2012 ◽

Vol 43 (3) ◽

pp. 844-850 ◽

Cited By ~ 62

Author(s):

Paul R. Krafft ◽

Orhan Altay ◽

William B. Rolland ◽

Kamil Duris ◽

Tim Lekic ◽

...

Keyword(s):

Mouse Model ◽

Intracerebral Hemorrhage ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Gsk 3Β

The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

Journal of the Neurological Sciences ◽

10.1016/j.jns.2014.06.032 ◽

2014 ◽

Vol 344 (1-2) ◽

pp. 94-99 ◽

Cited By ~ 11

Author(s):

Levke Steiner ◽

Maike Gold ◽

David Mengel ◽

Richard Dodel ◽

Jan-Philipp Bach

Keyword(s):

Receptor Antagonist ◽

Acetylcholine Receptor ◽

Kynurenic Acid ◽

Amyloid Β ◽

Microglial Cells ◽

Nicotinic Acetylcholine

Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

Journal of Neuroscience ◽

10.1523/jneurosci.6159-08.2009 ◽

2009 ◽

Vol 29 (27) ◽

pp. 8805-8815 ◽

Cited By ~ 123

Author(s):

G. Dziewczapolski ◽

C. M. Glogowski ◽

E. Masliah ◽

S. F. Heinemann

Keyword(s):

Alzheimer’S Disease ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Cognitive Deficits ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Synaptic Pathology ◽

Acetylcholine Receptor Gene