Deletion of the 7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

Journal of Neuroscience ◽

10.1523/jneurosci.6159-08.2009 ◽

2009 ◽

Vol 29 (27) ◽

pp. 8805-8815 ◽

Author(s):

G. Dziewczapolski ◽

C. M. Glogowski ◽

E. Masliah ◽

S. F. Heinemann

Keyword(s):

Alzheimer’S Disease ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cognitive Deficits ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Model Of Alzheimer’S Disease ◽

Synaptic Pathology ◽

Acetylcholine Receptor Gene

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Faculty Opinions recommendation of Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1163175.623850 ◽

2009 ◽

Author(s):

Mark A Smith ◽

Bo Su

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Cognitive Deficits ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Model Of Alzheimer’S Disease ◽

Synaptic Pathology ◽

Acetylcholine Receptor Gene ◽

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7 Nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease

Journal of Medical Genetics ◽

10.1136/jmg.2007.052704 ◽

2007 ◽

Vol 45 (4) ◽

pp. 244-248 ◽

Author(s):

R Carson ◽

D Craig ◽

B McGuinness ◽

J A Johnston ◽

F A O'Neill ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Acetylcholine Receptor Gene ◽

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Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer’s Disease

Molecular Imaging and Biology ◽

10.1007/s11307-018-1253-4 ◽

2018 ◽

Vol 21 (3) ◽

pp. 519-528 ◽

Author(s):

Yuki Matsuura ◽

Masashi Ueda ◽

Yusuke Higaki ◽

Kohei Sano ◽

Hideo Saji ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Model Of Alzheimer’S Disease ◽

The Relationship

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Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2017.10.021 ◽

2018 ◽

Vol 62 ◽

pp. 197-209 ◽

Author(s):

Kazuyuki Takata ◽

Takahide Amamiya ◽

Hiroaki Mizoguchi ◽

Shohei Kawanishi ◽

Eriko Kuroda ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Cognitive Impairment ◽

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Model Of Alzheimer’S Disease ◽

Secretase Activity

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Protein-tyrosine phosphatases specifically regulate muscle adult-type nicotinic acetylcholine receptor gene expression.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)46857-3 ◽

1994 ◽

Vol 269 (45) ◽

pp. 27811-27814

Author(s):

M K Sapru ◽

G Zhou ◽

D Goldman

Keyword(s):

Gene Expression ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Gene ◽

Protein Tyrosine Phosphatases ◽

Tyrosine Phosphatases ◽

Nicotinic Acetylcholine ◽

Acetylcholine Receptor Gene ◽

Receptor Gene Expression

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Nicotinic acetylcholine receptor gene expression in developing chick autonomic ganglia

European Journal of Pharmacology ◽

10.1016/s0014-2999(00)00029-7 ◽

2000 ◽

Vol 393 (1-3) ◽

pp. 97-104 ◽

Author(s):

Linda Erkman ◽

Jean-Marc Matter ◽

Lidia Matter-Sadzinski ◽

Marc Ballivet

Keyword(s):

Gene Expression ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Gene ◽

Autonomic Ganglia ◽

Nicotinic Acetylcholine ◽

Acetylcholine Receptor Gene ◽

Receptor Gene Expression

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Induction of adult-type nicotinic acetylcholine receptor gene expression in noninnervated regenerating muscle

Neuron ◽

10.1016/0896-6273(91)90377-c ◽

1991 ◽

Vol 7 (4) ◽

pp. 649-658 ◽

Author(s):

Daniel Goldman ◽

Bruce M. Carlson ◽

Julie Staple

Keyword(s):

Gene Expression ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Acetylcholine Receptor Gene ◽

Receptor Gene Expression

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Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)

Genomics ◽

10.1006/geno.1998.5363 ◽

1998 ◽

Vol 52 (2) ◽

pp. 173-185 ◽

Author(s):

Judith Gault ◽

Misi Robinson ◽

Ralph Berger ◽

Carla Drebing ◽

Judith Logel ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Genomic Organization ◽

Receptor Gene ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Partial Duplication ◽

Acetylcholine Receptor Gene

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A Novel Regulatory Element of a Nicotinic Acetylcholine Receptor Gene Interacts with a DNA Binding Activity Enriched in Rat Brain

Journal of Biological Chemistry ◽

10.1074/jbc.270.9.4497 ◽

1995 ◽

Vol 270 (9) ◽

pp. 4497-4502 ◽

Author(s):

Minjie Hu ◽

Catherine B. Bigger ◽

Paul D. Gardner

Keyword(s):

Dna Binding ◽

Rat Brain ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Regulatory Element ◽

Receptor Gene ◽

Binding Activity ◽

Nicotinic Acetylcholine ◽

Dna Binding Activity ◽

Acetylcholine Receptor Gene

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Prenatal exposure to maternal cigarette smoking interacts with a polymorphism in the α6 nicotinic acetylcholine receptor gene to influence drug use and striatum volume in adolescence

Molecular Psychiatry ◽

10.1038/mp.2009.63 ◽

2009 ◽

Vol 15 (1) ◽

pp. 6-8 ◽

Author(s):

S Lotfipour ◽

G Leonard ◽

M Perron ◽

B Pike ◽

L Richer ◽

...

Keyword(s):

Drug Use ◽

Cigarette Smoking ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Prenatal Exposure ◽

Receptor Gene ◽

Nicotinic Acetylcholine ◽

Maternal Cigarette Smoking ◽

Acetylcholine Receptor Gene

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