Cerebellar dentate nucleus functional connectivity with cerebral cortex in Alzheimer's disease and memory: a seed-based approach

2020 ◽  
Vol 89 ◽  
pp. 32-40 ◽  
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Giusy Olivito ◽  
Laura Serra ◽  
Camillo Marra ◽  
Carlotta Di Domenico ◽  
Carlo Caltagirone ◽  
...  
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Author(s):  
Yuken Fukutani ◽  
NigelJ. Cairns ◽  
IanP. Everall ◽  
Andrew Chadwick ◽  
Kiminori Isaki ◽  
...  

1996 ◽  
Vol 17 (4) ◽  
pp. S117
Author(s):  
Y. Fukutani ◽  
N.J. Cairns ◽  
I.P. Everall ◽  
A. Chadwick ◽  
K. Isaki ◽  
...  

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pp. 145-155 ◽  
Author(s):  
Zengqiang Zhang ◽  
Yong Liu ◽  
Bo Zhou ◽  
Jinlong Zheng ◽  
Hongxiang Yao ◽  
...  

2021 ◽  
pp. 1-6
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Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.


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Tiago Simas ◽  
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Roger Tait ◽  
Li Su ◽  
...  

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Vol 90 (4) ◽  
pp. 356-365 ◽  
Author(s):  
M. A. Mor�n ◽  
A. Probst ◽  
C. Navarro ◽  
P. G�mez-Ramos

Gerontology ◽  
1987 ◽  
Vol 33 (3-4) ◽  
pp. 197-202 ◽  
Author(s):  
Sandro Sorbi ◽  
Silvia Piacentini ◽  
Luigi Amaducci

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