Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin

NeuroImage ◽  
2005 ◽  
Vol 27 (4) ◽  
pp. 947-959 ◽  
Author(s):  
Joseph P. Culver ◽  
Andrew M. Siegel ◽  
Maria Angela Franceschini ◽  
Joseph B. Mandeville ◽  
David A. Boas
Keyword(s):  
Blood Volume ◽  
Spatial Resolution ◽  
Cerebral Blood Volume ◽  
Brain Activation ◽  
Deoxygenated Hemoglobin

scholarly journals Cerebral Blood Volume Changes during Brain Activation

2012 ◽  
Vol 32 (8) ◽  
pp. 1618-1631 ◽  
Author(s):  
Steffen Norbert Krieger ◽  
Markus Nikolar Streicher ◽  
Robert Trampel ◽  
Robert Turner
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Axial Flow ◽  
Brain Activation ◽  
Approximate Solutions ◽  
Theory Model ◽  
Surrounding Tissue ◽  
Apparent Paradox ◽  
Positron Emission ◽  
Capillary Membranes

Cerebral blood volume (CBV) changes significantly with brain activation, whether measured using positron emission tomography, functional magnetic resonance imaging (fMRI), or optical microscopy. If cerebral vessels are considered to be impermeable, the contents of the skull incompressible, and the skull itself inextensible, task- and hypercapnia-related changes of CBV could produce intolerable changes of intracranial pressure. Because it is becoming clear that CBV may be useful as a well-localized marker of neural activity changes, a resolution of this apparent paradox is needed. We have explored the idea that much of the change in CBV is facilitated by exchange of water between capillaries and surrounding tissue. To this end, we developed a novel hemodynamic boundary-value model and found approximate solutions using a numerical algorithm. We also constructed a macroscopic experimental model of a single capillary to provide biophysical insight. Both experiment and theory model capillary membranes as elastic and permeable. For a realistic change of input pressure, a relative pipe volume change of 21±5% was observed when using the experimental setup, compared with the value of approximately 17±1% when this quantity was calculated from the mathematical model. Volume, axial flow, and pressure changes are in the expected range.

scholarly journals On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRI

2008 ◽  
Vol 61 (3) ◽  
pp. 659-667 ◽  
Author(s):  
Jinsoo Uh ◽  
Kelly Lewis-Amezcua ◽  
Rani Varghese ◽  
Hanzhang Lu
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vascular Space
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