Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

2012 ◽  
Vol 62 (7) ◽  
pp. 2398-2408 ◽  
Author(s):  
Sandra L. Silva ◽  
Ana R. Vaz ◽  
Maria J. Diógenes ◽  
Nico van Rooijen ◽  
Ana M. Sebastião ◽  
...  
Keyword(s):  
Cell Death ◽  
Interleukin 10 ◽  
Unconjugated Bilirubin ◽  
Growth Impairment ◽  
Neuritic Growth ◽  
Glycoursodeoxycholic Acid

scholarly journals Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

2007 ◽  
Vol 66 (9) ◽  
pp. 789-798 ◽  
Author(s):  
Adelaide Fernandes ◽  
Ana Rita Vaz ◽  
Ana S. Falcão ◽  
Rui F. M. Silva ◽  
Maria A. Brito ◽  
...  
Keyword(s):  
Interleukin 10 ◽  
Unconjugated Bilirubin ◽  
Cortical Astrocytes ◽  
Glycoursodeoxycholic Acid

scholarly journals Interleukin-10 Prevents Glutamate-Mediated Cerebellar Granule Cell Death by Blocking Caspase-3-Like Activity

2001 ◽  
Vol 21 (9) ◽  
pp. 3104-3112 ◽  
Author(s):  
Alessia Bachis ◽  
Anna M. Colangelo ◽  
Stefano Vicini ◽  
Pylord P. Doe ◽  
Maria A. De Bernardi ◽  
...  
Keyword(s):  
Cell Death ◽  
Granule Cell ◽  
Caspase 3 ◽  
Interleukin 10 ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS

2004 ◽  
Vol 153 (1-2) ◽  
pp. 64-75 ◽  
Author(s):  
Adelaide Fernandes ◽  
Rui F.M Silva ◽  
Ana S Falcão ◽  
Maria A Brito ◽  
Dora Brites
Keyword(s):  
Cell Death ◽  
Cytokine Production ◽  
Glutamate Release ◽  
Unconjugated Bilirubin ◽  
Cultured Astrocytes

Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line

2010 ◽  
Vol 222 (2) ◽  
pp. 401-410 ◽  
Author(s):  
Marta Chevanne ◽  
Michele Zampieri ◽  
Riccardo Caldini ◽  
Angela Rizzo ◽  
Fabio Ciccarone ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Melanoma Cell ◽  
Melanoma Cell Line ◽  
Growth Impairment ◽  
Parp Activity

scholarly journals Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2

Immunology ◽  
1997 ◽  
Vol 92 (1) ◽  
pp. 1-5 ◽  
Author(s):  
S. B. A. COHEN ◽  
J. B. CRAWLEY ◽  
M. C. KAHAN ◽  
M. FELDMANN ◽  
B. M. J. FOXWELL
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Interleukin 10 ◽  
Apoptotic Cell Death

scholarly journals Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis

2003 ◽  
Vol 126 (4) ◽  
pp. 1174-1180 ◽  
Author(s):  
Stefan Fischer ◽  
Marc de Perrot ◽  
Mingyao Liu ◽  
Alexandra A MacLean ◽  
Jonathan A Cardella ◽  
...  
Keyword(s):  
Cell Death ◽  
Gene Transfection ◽  
Interleukin 10 ◽  
Cellular Necrosis

scholarly journals Lymphomagenesis in the SCID-hu mouse involves abundant production of human interleukin-10

Blood ◽  
1995 ◽  
Vol 85 (4) ◽  
pp. 1063-1074 ◽  
Author(s):  
RA Baiocchi ◽  
ME Ross ◽  
JC Tan ◽  
CC Chou ◽  
L Sullivan ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Tumor Cells ◽  
Human Peripheral Blood ◽  
Specific Binding ◽  
Interleukin 10 ◽  
Scid Mice ◽  
Chimeric Mouse ◽  
Severe Combined Immune Deficiency

Both human (hu) and viral (v) interleukin-10 (IL-10) appear to be important cofactors in the survival and growth of lymphoblastoid cell lines infected with Epstein-Barr virus (EBV). When mice with severe combined immune deficiency (SCID) are injected with human peripheral blood lymphocytes (PBL) from normal individuals who are seropositive for EBV, the majority of hu-PBL-SCID mice will develop an EBV- associated lymphoproliferative disease (EBV-LPD) of human B-cell origin, not unlike some cases of EBV-LPD that are seen in immunocompromised individuals. The role of huIL-10 or vIL-10 in this chimeric mouse model of EBV-LPD is unknown. In the present study, we show that hu-PBL-SCID mice that develop EBV-LPD have significant elevation of serum huIL-10 levels compared with mice that do not develop EBV-LPD (P = .005). vIL-10 was undetectable in all animals. The EBV+ tumor samples express transcript for huIL-10 and huIL-10 receptor, express huIL-10 protein by immunohistochemical staining, and show specific binding of recombinant (r) huIL-10. In vitro analysis of the functional consequences of rhuIL-10 binding to IL-10 receptors on fresh EBV+ tumor cells shows that rhuIL-10 can prevent programmed cell death as well as promote proliferation and can do so at concentrations of huIL-10 found in vivo. Thus, huIL-10 production by EBV+ tumor cells may contribute directly to their malignant outgrowth in the hu-PBL-SCID mouse by two autocrine mechanisms: prevention of programmed cell death and proliferation. The implications of such findings with regard to EBV- LPD in humans is discussed.

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