Dissociating cognitive deficits involved in voluntary eye movement dysfunctions in Parkinson's disease patients

2006 ◽  
Vol 44 (8) ◽  
pp. 1475-1482 ◽  
Author(s):  
S AMADOR ◽  
A HOOD ◽  
M SCHIESS ◽  
R IZOR ◽  
A SERENO
2015 ◽  
Vol 56 (3) ◽  
pp. 617-622 ◽  
Author(s):  
Z. Gan-Or ◽  
S. L. Girard ◽  
A. Noreau ◽  
C. S. Leblond ◽  
J. F. Gagnon ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Emily J. Henderson ◽  
Howard Chu ◽  
Daisy M. Gaunt ◽  
Alan L. Whone ◽  
Yoav Ben-Shlomo ◽  
...  

Background.MoCA is widely used in Parkinson’s disease (PD) to assess cognition. The Test Your Memory (TYM) test is a cognitive screening tool that is self-administered.Objectives.We sought to determine (a) the optimal value of TYM to discriminate between PD patients with and without cognitive deficits on MoCA testing, (b) equivalent MoCA and TYM scores, and (c) interrater reliability in TYM testing.Methods.We assessed the discriminant ability of TYM and the equivalence between TYM and MoCA scores and measured the interrater reliability between three raters.Results.Of the 135 subjects that completed both tests, 55% had cognitive impairment according to MoCA. A MoCA score of 25 was equivalent to a TYM score of 43-44. The area under the receiver operator characteristic (ROC) curve for TYM to differentiate between PD-normal and PD-cognitive impairment was 0.82 (95% CI 0.75 to 0.89). The optimal cutoff to distinguish PD-cognitive impairment from PD-normal was ≤45 (sensitivity 90.5%, specificity 59%) thereby correctly classifying 76.3% of patients with PD-cognitive impairment. Interrater agreement was high (0.97) and TYM was completed in under 7 minutes (interquartile range 5.33 to 8.52 minutes).Conclusions.The TYM test is a useful and less resource intensive screening test for cognitive deficits in PD.


2014 ◽  
Vol 20 (12) ◽  
pp. 1411-1414 ◽  
Author(s):  
Sophie Bayard ◽  
Yves Dauvilliers ◽  
Huan Yu ◽  
Muriel Croisier-Langenier ◽  
Alexia Rossignol ◽  
...  

2009 ◽  
Vol 24 (12) ◽  
pp. 1740-1746 ◽  
Author(s):  
Cristina Sanchez-Castaneda ◽  
Ramon Rene ◽  
Blanca Ramirez-Ruiz ◽  
Jaume Campdelacreu ◽  
Jordi Gascon ◽  
...  

2019 ◽  
Vol 59 ◽  
pp. 254-258 ◽  
Author(s):  
Hui Liu ◽  
Ruwei Ou ◽  
Qianqian Wei ◽  
Yanbing Hou ◽  
Bei Cao ◽  
...  

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Grisheila M. Koleangan ◽  
Arthur H. P. Mawuntu ◽  
Mieke A. H. M. Kembuan

Abstract: Rapid eye movement sleep behavior disorder (RBD) often occurs in patients with Parkinson's disease (PD) and it could reduce their quality of life (QoL). This study was aimed to obtain the characteristics and QoL of PD patients with pRBD in Manado. This was a descriptive study with a cross-sectional design. Subjects were PD patients with pRBD at Prof. Dr. R. D. Kandou Hospital from October to November 2019. The QoL was measured by using the SF-36 QoL questionnaire. The results obtained 48 eligible subjects. Male patients were more common than females (52.1% vs 47.9%). Most of the subjects were 60-69 years (54.1%), had senior high school and junior high school education (each of 29.1%), and unemployed (41.7%). Moreover, 62.5% of patients had been diagnosed as PD since 1-5 years ago. The mean score of the physical and mental component of the subjects were 46.5 and 60.8 subsequently. In conclusion, the majority of patients with Parkinson's disease and pRBD were 60-69 years, senior or junior high school educated, unemployed, and had been diagnosed as PD since 1-5 years ago. Their quality of life in physical component was below norm-based score but in mental component was still good.Keywords: Parkinson's disease, probable RBD, quality of life, SF-36 Abstrak: Gangguan perilaku tidur fase gerak mata cepat (rapid eye movement sleep behaviour disorder/RBD) sering terjadi pada pasien penyakit Parkinson (PD) yang mungkin menurunkan kualitas hidup mereka. Penelitian ini bertujuan untuk mengetahui karakteristik dan kualitas hidup pasien PD dengan probabel RBD (pRBD) di Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang terhadap pasien PD dengan pRBD yang datang ke RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober-November 2019. Kualitas hidup diukur menggu-nakan kuesioner kualitas hidup SF-36. Hasil penelitian mendapatkan 48 pasien yang meme-nuhi kriteria penelitian. Pasien berjenis kelamin laki-laki lebih banyak daripada perempuan (52,1% vs 47,9%). Sebagian besar pasien berada pada kelompok usia 60-69 tahun (54,1%), tingkat pendidikan terakhir SMA/Sederajat dan SMP sama banyak (29,1%), dan tidak bekerja (41,7%). Sebanyak 62,5% subjek telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Skor rerata komponen fisik dan komponen mental kualitas hidup SF-36 ialah 46,5 dan 60,8. Sim-pulan penelitian ini ialah mayoritas pasien penyakit Parkinson dengan pRBD berusia 60-69 tahun, pendidikan SMA/sederajat atau SMP, tidak bekerja, dan telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Kualitas hidup pasien penyakit Parkinson dengan pRBD pada komponen fisik secara umum berada di bawah skor normatif tetapi komponen mental masih baik.Kata kunci: penyakit Parkinson, probabel RBD, kualitas hidup, SF-36


2021 ◽  
Vol 13 ◽  
Author(s):  
Song’an Shang ◽  
Hongying Zhang ◽  
Yuan Feng ◽  
Jingtao Wu ◽  
Weiqiang Dou ◽  
...  

Background: Cognitive deficits are prominent non-motor symptoms in Parkinson’s disease (PD) and have been shown to involve the neurovascular unit (NVU). However, there is a lack of sufficient neuroimaging research on the associated modulating mechanisms. The objective of this study was to identify the contribution of neurovascular decoupling to the pathogenesis of cognitive decline in PD.Methods: Regional homogeneity (ReHo), a measure of neuronal activity, and cerebral blood flow (CBF), a measure of vascular responses, were obtained from patients with PD with mild cognitive impairment (MCI) and normal cognition (NC) as well as matched healthy controls (HCs). Imaging metrics of neurovascular coupling (global and regional CBF-ReHo correlation coefficients and CBF-ReHo ratios) were compared among the groups.Results: Neurovascular coupling was impaired in patients with PD-MCI with a decreased global CBF-ReHo correlation coefficient relative to HC subjects (P < 0.05). Regional dysregulation was specific to the PD-MCI group and localized to the right middle frontal gyrus, right middle cingulate cortex, right middle occipital gyrus, right inferior parietal gyrus, right supramarginal gyrus, and right angular gyrus (P < 0.05). Compared with HC subjects, patients with PD-MCI showed higher CBF-ReHo ratios in the bilateral lingual gyri (LG), bilateral putamen, and left postcentral gyrus and lower CBF-ReHo ratios in the right superior temporal gyrus, bilateral middle temporal gyri, bilateral parahippocampal gyri, and right inferior frontal gyrus. Relative to the HC and PD-NC groups, the PD-MCI group showed an increased CBF-ReHo ratio in the left LG, which was correlated with poor visual–spatial performance (r = −0.36 and P = 0.014).Conclusion: The involvement of neurovascular decoupling in cognitive impairment in PD is regionally specific and most prominent in the visual–spatial cortices, which could potentially provide a complementary understanding of the pathophysiological mechanisms underlying cognitive deficits in PD.


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