Homeostasis of glutamate in brain fluids: An accelerated brain-to-blood efflux of excess glutamate is produced by blood glutamate scavenging and offers protection from neuropathologies

Neuroscience ◽  
2009 ◽  
Vol 158 (1) ◽  
pp. 301-308 ◽  
Author(s):  
V.I. Teichberg ◽  
K. Cohen-Kashi-Malina ◽  
I. Cooper ◽  
A. Zlotnik
Keyword(s):  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging

The Contribution of the Blood Glutamate Scavenging Activity of Pyruvate to its Neuroprotective Properties in a Rat Model of Closed Head Injury

2007 ◽  
Vol 33 (6) ◽  
pp. 1044-1050 ◽  
Author(s):  
Alexander Zlotnik ◽  
Boris Gurevich ◽  
Evgenia Cherniavsky ◽  
Sergei Tkachov ◽  
Angela Matuzani-Ruban ◽  
...  
Keyword(s):  
Head Injury ◽  
Rat Model ◽  
Closed Head Injury ◽  
Scavenging Activity ◽  
Closed Head ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging

scholarly journals Blood Glutamate Scavenging: Insight into Neuroprotection

2012 ◽  
Vol 13 (8) ◽  
pp. 10041-10066 ◽  
Author(s):  
Akiva Leibowitz ◽  
Matthew Boyko ◽  
Yoram Shapira ◽  
Alexander Zlotnik
Keyword(s):  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging ◽  
Insight Into

Pyruvate’s blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke

2011 ◽  
Vol 34 (9) ◽  
pp. 1432-1441 ◽  
Author(s):  
Matthew Boyko ◽  
Alexander Zlotnik ◽  
Benjamin F. Gruenbaum ◽  
Shaun E. Gruenbaum ◽  
Sharon Ohayon ◽  
...  
Keyword(s):  
Rat Model ◽  
Scavenging Activity ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging

scholarly journals Sustained blood glutamate scavenging enhances protection in ischemic stroke

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Ahlem Zaghmi ◽  
Antonio Dopico-López ◽  
María Pérez-Mato ◽  
Ramón Iglesias-Rey ◽  
Pablo Hervella ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Infarct Volume ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Treated Group ◽  
The Body ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging ◽  
The Brain

AbstractStroke is a major cause of morbidity, mortality, and disability. During ischemic stroke, a marked and prolonged rise of glutamate concentration in the brain causes neuronal cell death. This study explores the protective effect of a bioconjugate form of glutamate oxaloacetate transaminase (hrGOT), which catalyzes the depletion of blood glutamate in the bloodstream for ~6 days following a single administration. When treated with this bioconjugate, a significant reduction of the infarct volume and a better retention of sensorimotor function was observed for ischemic rats compared to those treated with saline. Moreover, the equivalent dose of native hrGOT yielded similar results to the saline treated group for some tests. Targeting the bioconjugate to the blood-brain-barrier did not improve its performance. The data suggest that the bioconjugates draw glutamate out of the brain by displacing homeostasis between the different glutamate pools of the body.

scholarly journals Brain to blood glutamate scavenging as a novel therapeutic modality: a review

2014 ◽  
Vol 121 (8) ◽  
pp. 971-979 ◽  
Author(s):  
Matthew Boyko ◽  
Shaun E. Gruenbaum ◽  
Benjamin F. Gruenbaum ◽  
Yoram Shapira ◽  
Alexander Zlotnik
Keyword(s):  
Therapeutic Modality ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging ◽  
Novel Therapeutic

Effects of Blood Glutamate Scavenging on Cortical Evoked Potentials

2010 ◽  
Vol 30 (7) ◽  
pp. 1101-1106 ◽  
Author(s):  
Dávid Nagy ◽  
Levente Knapp ◽  
Máté Marosi ◽  
Tamás Farkas ◽  
Zsolt Kis ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Cortical Evoked Potentials ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging

scholarly journals Extracorporeal methods of blood glutamate scavenging: a novel therapeutic modality

2015 ◽  
Vol 15 (5) ◽  
pp. 501-508 ◽  
Author(s):  
Agzam Zhumadilov ◽  
Matthew Boyko ◽  
Shaun E Gruenbaum ◽  
Evgeny Brotfain ◽  
Federico Bilotta ◽  
...  
Keyword(s):  
Therapeutic Modality ◽  
Glutamate Scavenging ◽  
Blood Glutamate Scavenging ◽  
Novel Therapeutic
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