scholarly journals Effects of distal nerve injuries on dorsal-horn neurons and glia: Relationships between lesion size and mechanical hyperalgesia

Neuroscience ◽  
2009 ◽  
Vol 158 (2) ◽  
pp. 904-914 ◽  
Author(s):  
J.W. Lee ◽  
S.M. Siegel ◽  
A.L. Oaklander
Keyword(s):  
Dorsal Horn ◽  
Lesion Size ◽  
Mechanical Hyperalgesia ◽  
Nerve Injuries ◽  
Dorsal Horn Neurons ◽  
Distal Nerve

scholarly journals The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons

Pain ◽  
2007 ◽  
Vol 133 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Inhyung Lee ◽  
Hee Kee Kim ◽  
Jae Hyo Kim ◽  
Kyungsoon Chung ◽  
Jin Mo Chung
Keyword(s):  
Reactive Oxygen Species ◽  
Dorsal Horn ◽  
Reactive Oxygen ◽  
Mechanical Hyperalgesia ◽  
Oxygen Species ◽  
Dorsal Horn Neurons

scholarly journals Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
A. Di Lionardo ◽  
G. Di Stefano ◽  
C. Leone ◽  
G. Di Pietro ◽  
E. Sgro ◽  
...  
Keyword(s):  
Dorsal Horn ◽  
Ulnar Nerve ◽  
Central Sensitization ◽  
Placebo Treatment ◽  
Treatment Session ◽  
Mechanical Hyperalgesia ◽  
Double Blind ◽  
Neurophysiological Study ◽  
Dorsal Horn Neurons ◽  
Capsaicin Application

AbstractThe N13 component of somatosensory evoked potential (N13 SEP) represents the segmental response of dorsal horn neurons. In this neurophysiological study, we aimed to verify whether N13 SEP might reflect excitability changes of dorsal horn neurons during central sensitization. In 22 healthy participants, we investigated how central sensitization induced by application of topical capsaicin to the ulnar nerve territory of the hand dorsum modulated N13 SEP elicited by ulnar nerve stimulation. Using a double-blind placebo-controlled crossover design, we also tested whether pregabalin, an analgesic drug with proven efficacy on the dorsal horn, influenced capsaicin-induced N13 SEP modulation. Topical application of capsaicin produced an area of secondary mechanical hyperalgesia, a sign of central sensitization, and increased the N13 SEP amplitude but not the peripheral N9 nor the cortical N20-P25 amplitude. This increase in N13 SEP amplitude paralleled the mechanical hyperalgesia and persisted for 120 min. Pregabalin prevented the N13 SEP modulation associated with capsaicin-induced central sensitization, whereas capsaicin application still increased N13 SEP amplitude in the placebo treatment session. Our neurophysiological study showed that capsaicin application specifically modulates N13 SEP and that this modulation is prevented by pregabalin, thus suggesting that N13 SEP may reflect changes in dorsal horn excitability and represent a useful biomarker of central sensitization in human studies.

scholarly journals Neuron-specific spinal cord translatomes reveal a neuropeptide code for mouse dorsal horn excitatory neurons

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rebecca Rani Das Gupta ◽  
Louis Scheurer ◽  
Pawel Pelczar ◽  
Hendrik Wildner ◽  
Hanns Ulrich Zeilhofer
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Functional Organization ◽  
Affinity Purification ◽  
Expression Patterns ◽  
Inhibitory Neurons ◽  
Dorsal Horn Neurons ◽  
Expression Of Genes ◽  
Excitatory Neurons ◽  
Genes Encoding

AbstractThe spinal dorsal horn harbors a sophisticated and heterogeneous network of excitatory and inhibitory neurons that process peripheral signals encoding different sensory modalities. Although it has long been recognized that this network is crucial both for the separation and the integration of sensory signals of different modalities, a systematic unbiased approach to the use of specific neuromodulatory systems is still missing. Here, we have used the translating ribosome affinity purification (TRAP) technique to map the translatomes of excitatory glutamatergic (vGluT2+) and inhibitory GABA and/or glycinergic (vGAT+ or Gad67+) neurons of the mouse spinal cord. Our analyses demonstrate that inhibitory and excitatory neurons are not only set apart, as expected, by the expression of genes related to the production, release or re-uptake of their principal neurotransmitters and by genes encoding for transcription factors, but also by a differential engagement of neuromodulator, especially neuropeptide, signaling pathways. Subsequent multiplex in situ hybridization revealed eleven neuropeptide genes that are strongly enriched in excitatory dorsal horn neurons and display largely non-overlapping expression patterns closely adhering to the laminar and presumably also functional organization of the spinal cord grey matter.

Intradermal 5-HT induces Fos expression in rat dorsal horn neurons not via 5-HT3 but via 5-HT2A receptors

1997 ◽  
Vol 29 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Misako Doi-Saika ◽  
Atsushi Tokunaga ◽  
Emiko Senba
Keyword(s):  
Dorsal Horn ◽  
Dorsal Horn Neurons ◽  
Fos Expression
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